Tag: M.W=200-250

Kou, Huizhi published the artcileA new macrocyclic heterobinuclear Cu(II)-Zn(II) complex: synthesis, crystal structure, phosphate hydrolysis, and DNA binding studies, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Journal of Coordination Chemistry (2019), 72(10), 1683-1696, database is CAplus.

A new macrocyclic heterobinuclear Cu(II)-Zn(II) complex was synthesized and characterized by elemental anal., FTIR, ES-MS, and single-crystal x-ray diffraction. Five-coordinate geometry for the new complex is proposed. The Cu…Zn distance bridged by two phenolic oxygens and a acetate ligand is 2.9508 ?. The phosphate ester hydrolysis activity and the DNA binding ability of the complex were studied. The present complex has an efficient catalytic activity of phosphoester bond cleavage. The catalytic rate constant k_cat for the hydrolysis of 4-nitrophenyl phosphate disodium salt hexahydrate (pNPP) by the synthesized complex is 2.69 ¡Á 10^-4 s^-1 and 10⁵ times faster than the spontaneous hydrolysis of the phosphate monoester. The complex shows a good binding ability to calf thymus (CT-DNA) and the corresponding binding constant is 1.9 ¡Á 10⁵ M^-1. The linear Stern-Volmer quenching constant obtained by the fluorescent spectroscopic is 6.3 ¡Á 10⁴ M^-1.

Journal of Coordination Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Xingui published the artcileSenolytic activity of piperlongumine analogues: Synthesis and biological evaluation, COA of Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2018), 26(14), 3925-3938, database is CAplus and MEDLINE.

Selective clearance of senescent cells (SCs) has emerged as a potential therapeutic approach for age-related diseases, as well as chemotherapy- and radiotherapy-induced adverse effects. Through a cell-based phenotypic screening approach, we recently identified piperlongumine (PL), a dietary natural product, as a novel senolytic agent, referring to small mols. that can selectively kill SCs over normal or non-senescent cells. In an effort to establish the structure-senolytic activity relationships of PL analogs, we performed a series of structural modifications on the trimethoxyphenyl and the ¦Á,¦Â-unsaturated ¦Ä-valerolactam rings of PL. We show that modifications on the trimethoxyphenyl ring are well tolerated, while the Michael acceptor on the lactam ring is critical for the senolytic activity. Replacing the endocyclic C2-C3 olefin with an exocyclic methylene at C2 render PL analogs 47-49 with increased senolytic activity. These ¦Á-methylene containing analogs are also more potent than PL in inducing ROS production in WI-38 SCs. Similar to PL, 47-49 reduce the protein levels of oxidation resistance 1 (OXR1), an important oxidative stress response protein that regulates the expression of a variety of antioxidant enzymes, in cells. This study represents a useful starting point toward the discovery of senolytic agents for therapeutic uses.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Wei published the artcileNature of (001) and (00^–1) faces and flocculation flotation of kaolinite, COA of Formula: C14H31NO2, the publication is Transactions of Nonferrous Metals Society of China (2003), 13(4), 968-971, database is CAplus.

Flotation mechanism of kaolinite was investigated through flotation test, SEM anal., and quantum chem. simulation calculation The (001) face of kaolinite easily adsorb cationic collector to exhibit hydrophobicity; the (00^–1) face is easily interacted with the reagent carrying the group of high electronegativity (-O-, -N-, F-) to show hydrophilicity. The cationic and anionic polyacrylamide are adsorbed onto the (00^–1) face of kaolinite and the flocculation of kaolinite particles may take place; the (001) faces are exposed to interact with cationic collector to be rendered hydrophobicity. Thus, the macromols. can evidently enhance the flotation of kaolinite in alk. media.

Transactions of Nonferrous Metals Society of China published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C15H24O2, COA of Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Weiwei published the artcileElectro-optic thin films of organic nonlinear optic molecules aligned through vacuum deposition, COA of Formula: C14H14N2O2, the publication is Optics Express (2011), 19(12), 11189-11195, database is CAplus and MEDLINE.

Nonlinear optical mols. can be vacuum deposited into uniform thin films using thermal evaporation Alignment order can be achieved during thin film deposition by an in-plane elec. field poling using electrodes patterned on the substrate. Electro-optic (EO) coefficients, r₃₃ and r₁₃ are independently measured using Young’s interferometry technique. Thin-films of N-benzyl-2-methyl-4-nitroaniline (BNA) can exhibit an EO coefficient, r₃₃, comparable to that of BNA single crystals. EO coefficients of BNA at different poling fields, wavelengths, and frequencies are investigated.

Optics Express published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C12H10F2Si, COA of Formula: C14H14N2O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Seyferth, Dietmar published the artcileOrganometallic Chemistry of Ambident Dianions. Reactions of Organosilicon Dihalides with Acetone Dianions. Remarkable Difference in Reactivity between Diorganodichlorosilanes and Diorganodifluorosilanes, Computed Properties of 312-40-3, the publication is Organometallics (1995), 14(5), 2136-8, database is CAplus.

The [CH₂C(O)CPh₂]^2- dianion reacted with R₂SiCl₂ (R = Ph, CH₃, Et) to give cyclic products I but with R₂SiF₂ cyclic products II (R = Ph, Et) were formed. The structures of I and II (R = Ph) were determined by single-crystal x-ray diffraction. A reason for the difference in the regioselectivity of the reactions of the dianion with R₂SiCl₂ and R₂SiF₂ is suggested.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C10H15ClO3S, Computed Properties of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Tao published the artcileSynthesis and Biological Activity of 1-(Substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is Journal of Heterocyclic Chemistry (2015), 52(1), 173-179, database is CAplus.

A series of novel O,O-di-Me 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl/thien-2-yl)methylphosphonates were synthesized. Structures were confirmed by IR, ¹H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. Some possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas others possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50 mg/L.

Journal of Heterocyclic Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C14H20BClO2, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dong, Jianyang published the artcileFormyl-selective deuteration of aldehydes with D₂O via synergistic organic and photoredox catalysis, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Chemical Science (2020), 11(4), 1026-1031, database is CAplus and MEDLINE.

A mild general method for formyl-selective deuterium labeling of aldehydes with D₂O, an inexpensive deuterium source, via a synergistic combination of light-driven, polyoxometalate-facilitated hydrogen atom transfer and thiol catalysis was reported. This highly efficient, scalable reaction showed excellent deuterium incorporation, a broad substrate scope and excellent functional group tolerance and selectivity and was therefore a practical method for late-stage modification of synthetic intermediates in medicinal chem. and for generating libraries of deuterated compounds

Chemical Science published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kostelnik, Thomas I. published the artcileRapid Thermodynamically Stable Complex Formation of [^nat/111In]In³⁺, [^nat/90Y]Y³⁺, and [^nat/177Lu]Lu³⁺ with H₆dappa, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Inorganic Chemistry (2020), 59(10), 7238-7251, database is CAplus and MEDLINE.

A phosphinate-bearing picolinic acid-based chelating ligand (H₆dappa) was synthesized and characterized to assess its potential as a bifunctional chelator (BFC) for inorganic radiopharmaceuticals. NMR spectroscopy was employed to investigate the chelator coordination chem. with a variety of nonradioactive trivalent metal ions (In³⁺, Lu³⁺, Y³⁺, Sc³⁺, La³⁺, Bi³⁺). D. functional theory (DFT) calculations explored the coordination environments of aforementioned metal complexes. The thermodn. stability of H₆dappa with four metal ions (In³⁺, Lu³⁺, Y³⁺, Sc³⁺) was deeply investigated via potentiometric and spectrophotometric (UV-vis) titrations, employing a combination of acidic in-batch, joint potentiometric/spectrophotometric, and ligand-ligand competition titrations; high stability constants and pM values were calculated for all four metal complexes. Radiolabeling conditions for three clin. relevant radiometal ions were optimized ([¹¹¹In]In³⁺, [¹⁷⁷Lu]Lu³⁺, [⁹⁰Y]Y³⁺), and the serum stability of [¹¹¹In][In(dappa)]^3- was studied. Through concentration-, time-, temperature-, and pH-dependent labeling experiments, it was determined that H₆dappa radiolabels most effectively at near-physiol. pH for all radiometal ions. Furthermore, very rapid radiolabeling at ambient temperature was observed, as maximal radiolabeling was achieved in less than 1 min. Molar activities of 29.8 GBq/¦Ìmol and 28.2 GBq/¦Ìmol were achieved for [¹¹¹In]In³⁺ and [¹⁷⁷Lu]Lu³⁺, resp. For H₆dappa, high thermodn. stability did not correlate with kinetic inertness-lability was observed in serum stability studies, suggesting that its metal complexes might not be suitable as a BFC in radiopharmaceuticals. Thermodn. stability of H₆dappa metal complexes is very high, most notably In³⁺-dappa (left); radiolabeling of H₆dappa is rapidly occurring in just 1 min at room temperature with a host of radionuclides-shown here is labeling data with [¹⁷⁷Lu]Lu³⁺ (right).

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Li-Jun published the artcileChemically Sustainable and Green One-Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N-Fused-Pyrrolidine Heterocycles, Category: catalysis-chemistry, the publication is ChemistrySelect (2018), 3(2), 662-665, database is CAplus.

An eco-friendly, highly-efficient, atom-economical three-component cascade reaction of acenaphthenequinone, ¦Â-nitroolefins RCH=CHNO₂ (R = 2,4-dichlorophenyl, furan-2-yl, 1-methylindol-3-yl, etc.) and ¦Á-amino acids I (X = CH₂, CH₂CH₂, S; n = 1, 2) in MeOH/H₂O is developed for the synthesis of novel functionalized polycyclic N-fused-pyrrolidine derivatives II. All products are obtained by filtration in the absence of column chromatog. and recrystallization Due to its operational simplicity, this green and chem. sustainable reaction can be easily applied toward the design and synthesis of target mols. for the discovery of novel biol. active compounds

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C14H26O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ponou, Josiane published the artcileSeparation of palladium and silver from semiconductor solid waste by means of liquid-liquid extraction using dodecyl amine acetate as a surfactant collector, Computed Properties of 2016-56-0, the publication is Separation and Purification Technology (2018), 86-93, database is CAplus.

Liquid-liquid-powder extraction (LLPE) is the process of transferring fine solid particles from one liquid phase to another immiscible liquid in contact across the liquid-liquid boundary using a surface-active agent as a collector. LLPE was applied to semiconductor fine solid waste to extract valuable Pd and Ag particles from Al using dodecyl amine acetate (DAA) surfactant as collector, kerosene as an organic phase and pure water as the aqueous hydrophilic phase. Metal concentrations in each phase was dependent on solution pH, and the recovery of Pd and Ag was highly dependent on this parameter. However, a pH of 10 was optimal for separation of precious metals from Al, with Pd and Ag concentrating in the kerosene phase under this condition. The metal distribution as a function of DAA dosage at pH 10, showed that Pd and Al reached their maximum extraction percentages at a DAA dosage of 0.15%, whereas the Ag extraction percentage reached a maximum at a dosage of 0.2%. Thus, 0.15% was determined to be the optimum DAA dosage, which gave Pd and Ag concentrations 6.05 and 3.6 times higher than the feed, resp., with resp. extraction percentages of 87.78 ¡À 3.72% and 87.42 ¡À 3.81%. Moreover, 74.52 ¡À 7.72% of Al could be separated from Pd and Ag.

Separation and Purification Technology published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Computed Properties of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia