Tag: M.W=200-250

Ducrot, Aurelien published the artcilePhotolariats: synthesis, metal ion complexation and photochromism, Product Details of C10H10O6, the publication is Supramolecular Chemistry (2012), 24(7), 462-472, database is CAplus.

Photolariat development, as an extension to the family of synthetic photochromic crown ether receptors, or photocrowns, is reported. Incorporated addnl. chelating groups, namely two anisoles or thioanisoles, contribute in completing the metal ion coordination sphere with different affinities and selectivities for a range of ions. Single-crystal X-ray diffraction anal. suggests that the thermally stable trans-form of the receptor is unsuitable for ion binding, consistent with spectrophotometric and NMR titration results, which is largely improved in the cis-form as the basis for the photocontrolled ion coordination/ejection. In terms of the azobenzene-containing receptor photochem., a photostationary state highly enriched in the cis-form (94:6, cis-/trans-) is reached, with slow thermal return (1.1-1.4 ¡Á 10^–?⁵ s^–?¹) in the dark, which can undergo multiple cycles without discernable photodegradation

Supramolecular Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Product Details of C10H10O6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reffy, Jozsef published the artcileApplicability of the PPP and CNDO/2 methods for the structural investigation of organosilicon compounds. I, SDS of cas: 312-40-3, the publication is Acta Chimica Academiae Scientiarum Hungaricae (1977), 93(2), 107-16, database is CAplus.

Charge distribution, dipole moments, electron transition energies, and ionization energies of organosilicon compounds, i. e., PhSiF₃, MeSiPhF₂, CH₂:CHSiMe₃, CH₂:CHCH₂SiMe₃, were calculated by PPP, interative PPP, and CNDO/2 methods.

Acta Chimica Academiae Scientiarum Hungaricae published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, SDS of cas: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shalaby, Mostafa published the artcileIntense THz source based on BNA organic crystal pumped at Ti:sapphire wavelength, Formula: C14H14N2O2, the publication is Optics Letters (2016), 41(8), 1777-1780, database is CAplus and MEDLINE.

We report on high-energy terahertz pulses by optical rectification (OR) in the organic crystal N-benzyl-2-methyl-4-nitroaniline (BNA) directly pumped by a conventional Ti:sapphire amplifier. The simple scheme provides an optical-to-terahertz conversion efficiency of 0.25% when pumped by collimated laser pulses with duration of 50 fs and a central wavelength of 800 nm. The generated radiation spans frequencies between 0.2 and 3 THz. We measured the damage threshold, as well as the dependency of the conversion efficiency on the pump fluence, pump wavelength, and pulse duration.

Optics Letters published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C3H5F3O, Formula: C14H14N2O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Meninno, Sara published the artcileAsymmetric Epoxidation of Alkylidenemalononitriles: Key Step for One-Pot Approach to Enantioenriched 3-Substituted Piperazin-2-ones, COA of Formula: C16H20N2, the publication is Organic Letters (2015), 17(17), 4348-4351, database is CAplus and MEDLINE.

The first enantioselective epoxidation of readily available alkylidenemalononitriles has been developed by using a multifunctional cinchona derived thiourea as the organocatalyst and cumyl hydroperoxide as the oxidant. A new simple one-pot asym. epoxidation/S_N2 ring-opening reaction with 1,2-diamines leading to important enantioenriched heterocycles, i.e. 3-substituted piperazin-2-ones, e. g., I, has been established.

Organic Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishida, Masakazu published the artcileSynthesis of Polyfluoro Aromatic Ethers: A Facile Route Using Polyfluoroalkoxides Generated from Carbonyl and Trimethysilyl Compounds, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is Inorganic Chemistry (1995), 34(24), 6085-92, database is CAplus.

The polyfluoro aromatic ethers C₆F₅CH₂OR_F [R_F = CF₃, C₂F₅, CH₂CF₃, CF(CF₃)₂, C(CF₃)₃, C(CF₃)₂C₆F₅, C(CF₃)₂OCH₂CF₃, C(C₆F₅)₂CF₃], 4-CF₃CH₂OC₆F₄CH₂OCH₂CF₃, and C₆F₅CH₂OCF₂CF₂OCH₂C₆F₅ were synthesized from C₆F₅CH₂Br in the presence of CsF by reaction with the perfluoro carbonyl compounds COF₂, CF₃C(O)F, C₆F₅COF, (C₆F₅)₂CO, (CF₃)₂CO, and (COF)₂; reaction with polyfluoro siloxanes CF₃CH₂OSi(CH₃)₃ and C₆F₅OSi(CH₃)₃; or reaction with polyfluoroalkoxides generated from the fluorinated silanes CF₃Si(CH₃)₃, C₆F₅Si(CH₃)₃, and CF₃CH₂OSi(CH₃)₃ reacting with the carbonyl compounds listed above. Single-crystal X-ray anal. of C₆F₅CH₂OC(C₆F₅)₂CF₃ was reported. Reactivities of the carbonyl substrates and the silicon-containing reagents are discussed as a function of the alkyl (aryl) substituents present.

Inorganic Chemistry published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Recommanded Product: Trimethyl(perfluorophenyl)silane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zhen published the artcile5-(Diarylimino)- and 5-(sulfoximido)dibenzothiophenium triflates: syntheses and applications as electrophilic aminating reagents, Safety of Bis(4-fluorophenyl)methane, the publication is Organic & Biomolecular Chemistry (2021), 19(13), 2941-2948, database is CAplus and MEDLINE.

The one-pot synthesis of well-defined 5-(diarylimino) and 5-(sulfoximido)dibenzothiophenium triflates, resp. from diarylimines or sulfoximines, was reported and the structures of a series of these compounds were elucidated by X-ray crystallog. In analogy to their hypervalent I(III) analogs, the iminoyl and sulfoximidoyl groups of these compounds can be selectively transferred to organic substrates. Specifically, the uncatalyzed imination of thiols or sulfinates proceeds with good yields, while under the mild reaction conditions offered by visible light photoredox catalysis, the radical amination of hydrazones or the sulfoximidation of benzylic, allylic and propargylic C-H bonds takes place satisfactorily.

Organic & Biomolecular Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Safety of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bomon, Jeroen published the artcileBronsted Acid Catalyzed Tandem Defunctionalization of Biorenewable Ferulic acid and Derivates into Bio-Catechol, COA of Formula: C11H12O4, the publication is Angewandte Chemie, International Edition (2020), 59(8), 3063-3068, database is CAplus and MEDLINE.

An efficient conversion of biorenewable ferulic acid into bio-catechol was developed. The transformation comprises two consecutive defunctionalizations of the substrate, i.e., C-O (demethylation) and C-C (de-2-carboxyvinylation) bond cleavage, occurring in one step. The process only requires heating of ferulic acid with HCl (or H₂SO₄) as catalyst in pressurized hot water (250¡ã, 50 bar N₂). The versatility is shown on a variety of other (biorenewable) substrates yielding up to 84% di- (catechol, resorcinol, hydroquinone) and trihydroxybenzenes (pyrogallol, hydroxyquinol), in most cases just requiring simple extraction as work-up.

Angewandte Chemie, International Edition published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moon, Euy Sung published the artcileIn vitro evaluation of the squaramide-conjugated fibroblast activation protein inhibitor-based agents AAZTA⁵.SA.FAPi and DOTA.SA.FAPi, Application In Synthesis of 140-28-3, the publication is Molecules (2021), 26(12), 3482, database is CAplus and MEDLINE.

Recently, the first squaramide-(SA) containing FAP inhibitor-derived radiotracers were introduced. DATA^5m.SA.FAPi and DOTA.SA.FAPi with their non-radioactive complexes showed high affinity and selectivity for FAP. After a successful preclin. study with [⁶⁸Ga]Ga-DOTA.SA.FAPi, the first patient studies were realized for both compounds Here, we present a new squaramide-containing compound targeting FAP, based on the AAZTA⁵ chelator 1,4-bis-(carboxylmethyl)-6-[bis-(carboxymethyl)-amino-6-pentanoic-acid]-perhydro-1,4-diazepine. For this mol. (AAZTA⁵.SA.FAPi), complexation with radionuclides such as gallium-68, scandium-44, and lutetium-177 was investigated, and the in vitro properties of the complexes were characterized and compared with those of DOTA.SA.FAPi. AAZTA⁵.SA.FAPi and its derivatives labeled with non-radioactive isotopes demonstrated similar excellent inhibitory potencies compared to the previously published SA.FAPi ligands, i.e., sub-nanomolar IC₅₀ values for FAP and high selectivity indexes over the serine proteases PREP and DPPs. Labeling with all three radiometals was easier and faster with AAZTA⁵.SA.FAPi compared to the corresponding DOTA analog at ambient temperature Especially, scandium-44 labeling with the AAZTA derivative resulted in higher specific activities. Both DOTA.SA.FAPi and AAZTA⁵.SA.FAPi showed sufficiently high stability in different media. Therefore, these FAP inhibitor agents could be promising for theranostic approaches targeting FAP.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tie, Yaxin published the artcileDevelopment and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market, Formula: C16H20N2, the publication is Talanta (2019), 876-887, database is CAplus and MEDLINE.

Estimations, made by the World Health Organization (WHO), state that 10% of the medical products in low- and middle-income countries are substandard or falsified (SF). Among them, antibiotics and antimalarials are the most commonly reported since 2013. Besides the fact that falsification is a crime, the worldwide use of poor quality antimicrobials could result in treatment failures, stronger antimicrobial resistance and even the promotion of the emergence of superbugs. Therefore, simple and accurate anal. methods are necessary, which are capable to detect and quantify a wide range of antimicrobials in suspected illegal products. In this work, a screening and a quantification method using ultra-high performance liquid chromatog. with tandem mass spectrometry (UHPLC-MS²) and diode array detection (UHPLC-DAD), resp. were developed and validated. These methods could be used for routine anal. and enable a more in-depth characterization of SF-antimicrobials. According to their popularity as SF-antimicrobials, 31 antibiotics, 3 antibacterial agents, 1 antifungal agent and 1 ¦Â-lactamase inhibitor, covering eleven different antibacterial classes, were selected. The UHPLC-MS² screening method with gradient elution is able to selectively detect these 36 compounds within 18 min (including wash and equilibration step). It was validated for sensitivity, selectivity and matrix effects. Within an anal. time of 32 min, the UHPLC-DAD method could quantify 32 compounds (4 showed insufficient UV absorbance) and resulted in sufficient selectivity, necessary since some SF-antimicrobials may include more than one antimicrobial component. This quantification method was validated for the pos. hits found during screening tests of suspected illegal samples. This resulted in a validation set of 11 antimicrobials and 1 ¦Â-lactamase inhibitor. The ”total error” approach in accordance with the validation requirements of ISO-17025 was employed for the validation. 57 real-life illegal samples, seized by inspectors from the Belgium Federal Agency for Medicinal and Health Products (FAMHP), were analyzed using the two described methods. About half of them were not compliant and some samples that contained clavulanic acid showed a serious reduction in the amount of this mol. (in one sample only 14% of the claimed dosage was found). These quality issues might be attributed to either poor manufacturing, storage or transportation conditions.

Talanta published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H16OSi, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sunitha, P. G. published the artcileValidated RP-HPLC PDA method for estimation of trientine hydrochloride in pharmaceutical dosage form, Synthetic Route of 38260-01-4, the publication is International Journal of ChemTech Research (2019), 12(1), 87-92, database is CAplus.

The present work reports a reverse phase high performance liquid chromatog. (RP-HPLC) method for the determination of Trientine hydrochloride in pharmaceutical dosage form. HPLC was performed using Waters reliant C₈ column (250 mm ¡Á 4.6 mm ID, 5¦Ìm particle size ) using a mixture of Acetronitrile : Ammonium formate buffer pH 5.3 ¡À 0.05 as mobile phase. UV detection was carried out at 220 nm. The retention time of Trientine hydrochloride was found to be 12.497min. The developed method was validated as per ICH guidelines. The proposed method was found to be suitable for the quantification of the selected drug in pharmaceutical dosage form.

International Journal of ChemTech Research published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C7H11N, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia