Tag: M.W=200-250

Jadhav, Nikhil C. published the artcileDesign, synthesis and molecular docking study of novel pyrrole-based ¦Á-amylase and ¦Á-glucosidase inhibitors, Product Details of C10H11NO4, the publication is Medicinal Chemistry Research (2017), 26(10), 2675-2691, database is CAplus.

In an effort to design and synthesize a new class of ¦Á-glucosidase and ¦Á-amylase inhibitors, we have synthesized novel pyrrole based mols. using mol. hybridization approach. These novel analogs were synthesized by the novel methodol. developed in our lab which comprises of the multi-component direct synthesis route using hypervalent iodine reagent. The compounds were characterized by IR, ¹H NMR (NMR), ¹³C NMR and Mass Spectroscopy. These compounds were screened for their ¦Á-amylase and ¦Á- glucosidase activity. They showed a varying degree of inhibition with IC₅₀ values ranging between 0.4 to 4.14 ¦Ìmol/mL and 0.8 to 4.14 ¦Ìmol/mL for ¦Á-amylase and ¦Á-glucosidase resp. Compounds 3, 7, 12, and 18 showed excellent activity as compared to standard acarbose. This has identified a new class of ¦Á-amylase and ¦Á-glucosidase inhibitor which can be further developed as antihyperglycemic agents. The mol. docking anal. was carried out to better understand of interaction between ¦Á-amylase and ¦Á-glucosidase target and inhibitors in this series. We also generated a homol. model for human ¦Á-glucosidase enzyme and identified the key residues at the binding site. The outcome of the study could be used for the rational design of potent and selective ¦Á-amylase and ¦Á-glucosidase inhibitors, resp.

Medicinal Chemistry Research published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Suguna, H. published the artcilePhotolytic syntheses of dl-anolobine and dl-9-hydroxy-2,3-methylenedioxyberbine, Quality Control of 1860-58-8, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1977), 15B(5), 416-18, database is CAplus.

Debenzylation of the isoquinoline I (R = PhCH2, R1 = Br) gave I (R = H, R1 = Br) and bromohydroxymethylenedioxyberbine II. Photolysis of I (R = H, R1 = Br).HCl gave (¡À)-anolobine (III), I (R = R1 = H), and II. II on reductive debromination gave 9-hydroxy-2,3-methylenedioxyberbine. IR spectrum of synthetic anolobine was identical with that of natural anolobine.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C21H37BO, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Occhialini, Gino published the artcileCatalytic, contra-Thermodynamic Positional Alkene Isomerization, Product Details of C15H24S, the publication is Journal of the American Chemical Society (2022), 144(1), 145-152, database is CAplus and MEDLINE.

The discovery of a dual catalyst system that promotes contra-thermodn. positional alkene isomerization under photochem. irradiation, providing access to terminal alkene isomers, e.g., (2-methylallyl)benzene directly from conjugated, internal alkene, e.g., (2-methylpropenyl)benzene starting materials was reported. The utility of the method is demonstrated in the deconjugation of diverse electron-rich/electron-poor alkenes and through strategic application to natural product synthesis, e.g., (-)-nopinone. Mechanistic studies are consistent with a regiospecific bimol. homolytic substitution (S_H2′) mechanism proceeding through an allyl-cobaloxime intermediate.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Product Details of C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ragle, Lauren E. published the artcileDiscovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition, HPLC of Formula: 163839-73-4, the publication is Bioorganic & Medicinal Chemistry (2016), 24(19), 4660-4674, database is CAplus and MEDLINE.

Autotaxin (ATX) is a ubiquitous ectoenzyme that hydrolyzes lysophosphatidylcholine (LPC) to form the bioactive lipid mediator lysophosphatidic acid (LPA). LPA activates specific G-protein coupled receptors to elicit downstream effects leading to cellular motility, survival, and invasion. Through these pathways, upregulation of ATX is linked to diseases such as cancer and cardiovascular disease. Recent crystal structures confirm that the catalytic domain of ATX contains multiple binding regions including a polar active site, hydrophobic tunnel, and a hydrophobic pocket. This finding is consistent with the promiscuous nature of ATX hydrolysis of multiple and diverse substrates and prior investigations of inhibitor impacts on ATX enzyme kinetics. The current study used virtual screening methods to guide exptl. identification and characterization of inhibitors targeting the hydrophobic region of ATX. An initially discovered inhibitor, GRI392104 (IC₅₀ 4 ¦ÌM) was used as a lead for synthetic optimization. In total twelve newly synthesized inhibitors of ATX were more potent than GRI392104 and were selective for ATX as they had no effect on other LPC-specific NPP family members or on LPA_1-5 GPCR.

Bioorganic & Medicinal Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, HPLC of Formula: 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jash, Apratim published the artcileActivated release of bioactive aldehydes from their precursors embedded in electrospun poly(lactic acid) nonwovens, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is RSC Advances (2018), 8(36), 19930-19938, database is CAplus and MEDLINE.

Hexanal and benzaldehyde are naturally-occurring aroma compounds from plants with enzyme-inhibition and antimicrobial properties. Although useful for food preservation applications, the end-use of these compounds can be challenging due to their volatility and susceptibility to oxidative degradation In this study, stable precursors for benzaldehyde and hexanal were synthesized via reversible condensation reactions with N,N¡ä-dibenzylethane-1,2-diamine. The mol. structures of the resulting 1,3-dibenzylethane-2-Ph and 1,3-dibenzylethane-2-pentyl imidazolidines were confirmed by NMR analyses. The precursors were encapsulated in poly(lactic acid) fibers via electrospinning, using a 90 : 10 Et formate : DMSO blend as a solvent. Triggered release of benzaldehyde and/or hexanal from the resulting active nonwovens was achieved by the addition of 1 N citric acid, which can be described using a pseudo first order kinetic equation involving rapid and slow release steps.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Marques Borges, Gabriel Silva published the artcileNovel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all-trans retinoic acid, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Nanomedicine (London, United Kingdom) (2020), 15(15), 1471-1486, database is CAplus and MEDLINE.

All-trans retinoic acid (ATRA) shows erratic oral bioavailability when administered orally against leukemia, which can be solved through its incorporation in self-nanoemulsifying drug-delivery systems (SEDDS). The SEDDS developed contained a hydrophobic ion pair between benzathine (BZT) and ATRA and was enriched with tocotrienols by the input of a palm oil tocotrienol rich fraction (TRF) in its composition SEDDS-TRF-ATRA-BZT allowed the formation of emulsions with nanometric size that retained ATRA within their core after dispersion. Pharmacokinetic parameters after oral administration of SEDDS-TRF-ATRA-BZT in mice were improved compared with what was seen for an ATRA solution Moreover, SEDDS-TRF-ATRA-BZT had improved activity against HL-60 cells compared with SEDDS without TRF. SEDDS-TRF-ATRA-BZT is a promising therapeutic choice over ATRA conventional medicine. SEDDS-TRF-ATRA-BZT after dispersion in ultrapure water produces nanoemulsions that have improved ATRA oral pharmacokinetics in Swiss male mice and improved its differentiation and cytotoxic properties against HL-60 cells.

Nanomedicine (London, United Kingdom) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reis, Joana published the artcileExploring nitrostyrene as a scaffold for a new class a of monoamine oxidase inhibitors, Related Products of catalysis-chemistry, the publication is Letters in Drug Design & Discovery (2012), 9(10), 958-961, database is CAplus.

To find the structural features that are relevant for MAO inhibitory activity and selectivity towards MAO-B isoform, a series of compounds encompassing a ¦Â-nitrostyrene moiety was designed and the in vitro inhibitory activity was evaluated. The synthesis and pharmacol. evaluation of a series of functionalized derivatives of ¦Â-methyl-¦Â-nitrostyrene with distinct substitution patterns in the Ph ring, namely HO, MeO, PhCH₂O, and H₂CO₂ was reported. All the studied compounds were substituted in meta and para positions of the Ph ring related to the nitrovinyl side-chain. The synthesized compounds were evaluated for activity towards both human MAO isoforms, and some of them displayed activities in the low micromolar range. Particularly a methylenedioxy derivative exhibited high potency and selectivity towards MAO-B.

Letters in Drug Design & Discovery published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yamashita, Hiroshi published the artcileIon flotation of metal-(1-hydroxyethylidene)bisphosphonate complexes and determination of stability constants of the complexes, Name: Dodecylamineacetate, the publication is Nippon Kagaku Kaishi (1991), 168-9, database is CAplus.

Ion flotation of sixteen metal ions (Mn(II), Co(II), Cd(II), Zn(II), Ni(II), Cu(II), Pb(II), Bi(III), Fe(III), In(III), Ga(III), Cr(III), Y(III), V(V), Mo(VI), Cr(VI)) was investigated in (1-hydroxyethylidene)bisphosphonic acid (HEBP) solutions with dodecylammonium acetate (DAA) as a surfactant. A 20 cm³ aliquot of 4.38 ¡Á 10^-4 mol.dm^-3 HEBP solution containing (3.94?4.32) ¡Á 10^-4 mol/dm³ of the above-mentioned metal ions and 8.77 ¡Á 10^-4 mol/dm³ of DAA was adjusted to the desired pH and subjected to flotation in a cell (20 ¡Á 2.5 cm i.d.) for 10 ? 20 min with nitrogen bubbles. The effect of pH on the recovery of metal ions was examined and recoveries of 98?100% (except for Cr(VI)) were obtained at the appropriate pH ranges. The compositions of the floated complexes were determined to be a metal/HEBP ratio of 1:1 for the divalent metal ions. The stability constants of the complexes were also determined from the pH?percent flotation curves by nonlinear least-squares method.

Nippon Kagaku Kaishi published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C8H8BFO2, Name: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takeda, Shuichi published the artcileMetabolic fate of triethylenetetramine dihydrochloride (trientine hydrochloride, TJA-250) 1. Absorption, distribution and excretion in rats after single administration of ¹⁴C-TJA-250, Category: catalysis-chemistry, the publication is Oyo Yakuri (1995), 49(2), 163-71, database is CAplus.

The absorption, distribution and excretion of radioactivity were investigated in rats after single i.v. or oral administration of ¹⁴C-TJA-250 (triethylenetetramine dihydrochloride). Oral administration of ¹⁴C-TJA-250 at a dose of 25 mg/kg produced a maximal plasma concentration (C_max) at 1 h, after which the plasma level fell with half lives of 1.69 and 30.35 h. When the same dose was given i.v., the radioactivity rose to the maximum level at 30 min after administration and then the level fell with a half life of 1.27 h up to 6 h. The AUC (area under the curve) values after i.v. and oral administration were 74.67 and 33.05 ¦Ìg eq. * hr/mL, resp. and the extent of absorption after oral dose was 44.3%. The C_max and AUC obtained from rats not in a fasting state corresponded to 73.9 and 86.2%, resp., of the values in rats in a fasting state. There was a dose-dependent increase in C_max and AUC after oral administration of 10 to 62.5 mg/kg. Sex difference was observed in plasma radioactivity concentration Within 168 h after single intraveonus and oral administration, 95.40 and 39.80%, resp., of dose was excreted into urine; 3.26 and 58.34%, resp., into feces; and 0.62 and 0.69%, resp., into expired air. Biliary excretion was only 0.86% of dose within 48 h and 1 h after oral administration. High radioactivity was found mainly in kidney and liver. No definite accumulation of radioactivity occurred in any tissues 168 h after administration. The distribution of radioactivity after i.v. administration was similar to that after oral dosing.

Oyo Yakuri published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C10H10N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takeda, Shuichi published the artcileMetabolic fate of triethylenetetramine dihydrochloride (trientine hydrochloride, TJA-250) 3. Bioavailability of TJA-250 in rats after single administration, Application of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Oyo Yakuri (1995), 49(2), 179-86, database is CAplus.

A study was made with respect to the bioavailability of TJA-250 (triethylenetetramine dihydrochloride) in rats after single i.v. and oral administration. The plasma concentration was determined by HPLC with fluorescence detection; TJA-250 was labeled with fluorescamine before injection. The plasma concentration of TJA-250 rapidly fell with a half life of 0.54 and 0.65 h after i.v. administration at doses of 5 and 25 mg/kg, resp. In rats in a fasting state and those not in a fasting state, oral administration of 25 mg/kg of TJA-250 produced maximal plasma concentrations of 0.5 h, after which the plasma concentrations fell with a half life of 0.97 and of 1.57 h, resp. The bioavailability was 25.5% in rats in a fasting state and 14.0% in rats not in a fasting state. After intraduodenal administration of the same dose, the AUC was larger than that after oral administration. The effects of various factors, e.g. metal ions, laboratory chow and concentration of TJA-250 in a dosage solution on the absorption of TJA-250 from gut were studied by the in situ loop technique in rats. The absorption was affected by the concentration of dosage solution in a concentration-dependent manner. Liver perfusion study showed a poor metabolism of TJA-250. These results indicate that the concentration of dosage solution and first pass metabolism in intestinal wall may play an important role in the absorption of TJA-250 in humans as well as in rats.

Oyo Yakuri published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C4H7BrO2, Application of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia