Tag: M.W=200-250

Klingebiel, Uwe published the artcileFluorosilyl-substituted N,N- and N,O-bis(trimethylsilyl)hydroxylamines, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of Organometallic Chemistry (1979), 179(4), 391-6, database is CAplus.

Fluoro- and aminofluorosilanes react with the Li salt on N,O-bis(trimethylsilyl)hydroxylamine with LiF elimination and substitution. Alkyl- and aminofluorosilanes give O-fluorosilyl-N,N-bis(trimethylsilyl)hydroxylamines, arylfluorosilanes give N-fluorosilyl-N,O-bis(trimethylsilyl)hydroxylamines. By the further reaction of O-difluorosilyl-N,N-bis(trimethylsilyl)hydroxylamine with the lithiated hydroxylamine, O,O‘-fluoromethylsilyldi[N,N-bis(trimethylsilyl)hydroxyalmine] is formed. On heating N-difluorophenylsilyl-N,O-bis(trimethylsilyl)hydroxylamine, di[fluorophenylsilyl(methyl)amino]pentamethylsiloxane is formed by Me group migration.

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hedvati, Lilach published the artcileCinnamic acid derived oxazolinium ions as novel cytotoxic agents, Synthetic Route of 16909-09-4, the publication is European Journal of Medicinal Chemistry (2002), 37(7), 607-616, database is CAplus and MEDLINE.

Substituted cinnamoyl chlorides were converted into (2-hydroxyethyl)oxazolinium chlorides (I), N,N-bis-(2-chloroethyl)amides, and (2-chloroethyl)oxazolinium chlorides. Although I which possess electron-donating substituents (Me or MeO) were more potent than those substituted by electron-withdrawing groups (NO₂, Cl or CF₃), the difference in cytotoxic action was not significant. Modification of the lipophilic character in a series of alkoxy-substituted I led to more active compounds, the octyloxyphenyl derivative II being the most potent and displaying cytotoxic activity in the ¦ÌM range. It is assumed that the oxazolinium salts act as alkylating agents, and undergo nucleophilic attack on the methylene adjacent to the ring oxygen where the oxazolinium ring parallels the aziridinium ring intermediate found in classical alkylating agents.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Synthetic Route of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bevers, Susan published the artcilePerylene- and Naphthalene-Based Linkers for Duplex and Triplex Stabilization, Application In Synthesis of 215297-17-9, the publication is Journal of the American Chemical Society (1998), 120(42), 11004-11005, database is CAplus.

Perylene and naphthalene were chosen for development into planar ¦Ð-stacking linkers in DNA duplex or triplex preparations Linkers were prepared by reaction of the corresponding tetra-carboxylic acid dianhydride with 2-aminoethoxyethanol or its tBDMS derivative Thermal stabilities of DNA duplex (5′-TCTTTTCTT-linker-AAGAAAAGA) or triplex (5′-TCTTTTCTT-linker-TTCTTTTCT/9-mer or 19-mer) systems. Both the perylene and naphthalene-based duplex linkers showed increased T_M values, compared to a duplex tethered by hexa(ethylene glycol), but the perylene linker showed only a small increase over naphthalene, perhaps because it is significantly larger than necessary to bridge the phosphate residues at the terminus of a B-form helix, while the naphthalene-based linker can be more optimally positioned at the end of a duplex. In triplex formation, the most significant T_M enhancements were those that occurred with the 19-mer complex, where the perylene-based linker showed a 19¡ã increase at pH 5.5; for both linkers, this is perhaps due to their potential to provide stacking interactions with all three residues, and possibly with the first base residue of the target strand that extends beyond the triplex region.

Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Application In Synthesis of 215297-17-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Howell, Barbara F. published the artcileRadiation cured, environmentally compliant, pigmented coatings, Synthetic Route of 2909-77-5, the publication is Proceedings – Electrochemical Society (1997), 29-39, database is CAplus.

Pigmented epoxy acrylate coatings were developed which could be successfully cured using a xenon or mercury lamp. Coatings applied to grit blasted steel panels passed crosshatch adhesion, impact, balanced beam scrape adhesion, and 500-h 49¡ã salt fog tests. A pigment formulation suitable for radiation curing was found. In addition, visible light-sensitive, photobleaching photoinitiators were tested, and it was found that the pigmented coating formulation could be successfully cured with a metal halide electrodeless bulb, which emits light in the short visible wavelength range, as well as with a sufficiently intense tungsten halogen lamp. Because of the photobleaching, the coating did not yellow, and problems with exposure to UV radiation were minimized with visible radiation bulbs.

Proceedings – Electrochemical Society published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Synthetic Route of 2909-77-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kursun, Ilgin published the artcileApplication of novel flotation process for removal of feldsphatic minerals from quartz sands, HPLC of Formula: 2016-56-0, the publication is Asian Journal of Chemistry (2004), 16(2), 937-941, database is CAplus.

In this study, conventional flotation process using hydrofluoric acid was compared to a novel flotation process without using hydrofluoric acid for separation of feldspar from quartz sands. In the new method, feldspars are floated from quartz sands using two different reagents; sodium oleate and dodecyl amine acetate together as collectors for satisfactory and environment friendly beneficiation without using hydrofluoric acid.

Asian Journal of Chemistry published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, HPLC of Formula: 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nakazawa, Hiroshi published the artcileSeparation of sericite from quartz by amine flotation, Recommanded Product: Dodecylamineacetate, the publication is Nippon Kogyo Kaishi (1988), 104(1209), 803-7, database is CAplus.

Sericite separation from quartz by flotation was investigated, using dodlecylammonium acetate (DAA) as the collector. Sericite floats in acidic solution with a large amount of DAA. Sericite can be selectively separated from quartz in a pH 2.5 solution The addition of Al³⁺ decreases the amount of DAA required for the flotation of sericite. In a pH 10.5 solution, the separation of sericite from quartz is not good but, with an addition of Al³⁺, sericite can be separated from quartz.

Nippon Kogyo Kaishi published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Henriet, Theo published the artcileTriethylenetetramine Dihydrochloride: Interactions and Conformations in Two Anhydrous Structures and a Hydrate, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Crystal Growth & Design (2015), 15(1), 348-357, database is CAplus.

Triethylenetetramine is a polyamine type chelating ligand for Cu(II), which is currently used, mainly in its dihydrochloride form, as an alternative to D-penicillamine against Wilson’s disease. Because knowledge about the solid-state behavior of pharmaceuticals is a prerequisite for the development of an effective dosage form, the crystal structures of two triethylenetetramine dihydrochloride polymorphs were determined, and the IR spectra and thermal expansion were studied. No suitable crystals could be obtained of the two anhydrous forms, for which the structures were solved from x-ray powder diffraction. Form I is monoclinic, space group P2₁/n with a 11.0475(4), b 4.87475(16), c 11.1178(4) ?, and ¦Â 106.9826(13)¡ã with Z = 2. Form II is also monoclinic, space group P2₁/c with a 10.6734(6), b 12.3613(6), c 9.8479(7) ?, and ¦Â 115.985(3)¡ã with Z = 4. A recurring structural element is a ionic interaction between two chloride ions and two ammonium groups each organized in a diamond pattern present in the dihydrate (the salt is hygroscopic) and anhydrous form I. The mol. conformations are different in both anhydrous forms and in the dihydrate. Comparison of the thermal expansions demonstrates that form I has the smallest thermal expansion and thus possesses the strongest intermol. interactions.

Crystal Growth & Design published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guan, Zong published the artcileOrganic Synthesis with N-Heterocyclic Carbenes of Indazole: Synthesis of Benzo(thio)imidates, Benzo[d][1,3]thiazines and Quinazoline-4-thiones, Computed Properties of 22693-41-0, the publication is European Journal of Organic Chemistry (2015), 2015(21), 4710-4719, database is CAplus.

The N-heterocyclic carbenes of indazole, generated by deprotonation of indazolium salts, proved to be versatile starting materials for organic synthesis. They undergo ring-opening reactions to generate ketenimines which readily add thiols thus affording the first examples of 2-anilinobenzothioimidates. Water converts the ring-opened intermediates into functionalized 2-anilinobenzamides which can be thionated with Lawesson’s reagent and subsequently cyclized with formaldehyde and propionaldehyde, resp., to give benzo[d][1,3]thiazines and quinazoline-4-thiones. The outcome of the cyclization depends upon the thiobenzamide substitution pattern.

European Journal of Organic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Computed Properties of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tomita, Masao published the artcileSyntheses of biscoclaurine alkaloids. III. Synthesis of dl-3,4′-bis(2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolylmethyl)diphenyl ether, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Yakugaku Zasshi (1959), 1019-22, database is CAplus.

cf. C.A. 53, 5315a. Vanillin was methylated with alk. Me₂SO₄ to veratraldehyde, which was condensed with MeNO₂ in MeOH and MeNH₂ to give 3,4-(MeO)₂C₆H₃CH:CHNO₂, which was electrolytically reduced in 15:12:45 AcOH-HCl-MeOH to 3,4-(MeO)₂C₆H₃CH₂CH₂NH₂ (I); oxalate m. 178¡ã. 3-PhCH₂OC₆H₄ CH₂CO₂H (II), m. 124-6¡ã, was prepared through the route of 3-O₂NC₆H₄CHO, m. 56-8¡ã, 3-HOC₆H₄CHO, m. 103-4¡ã, 2-phenyl-4-(3-benzyloxybenzylidene)-2-oxazolin-5-one, m. 129-31¡ã, to II. I (from 5.5 g. of its oxalate) in Et₂O and 50 ml. 10% KOH treated dropwise with 3-PhCH₂OC₆H₄CH₂COCl (from 5 g. II in CHCl₃ and SOCl₂), stirred 1 hr., the Et₂O layer and CHCl₃ extract of the aqueous layer concentrated, washed with dilute HCl and H₂O and the product recrystallized (MeOH) gave 6 g. 3-PhCH₂OC₆H₄CH₂CONHCH₂CH₂C₆H₃(OMe)₂-3,4 (III), needles, m. 97-100¡ã. III (3 g.) in 45 ml. PhMe and 6 ml. POCl₃ refluxed 1.5 hrs., and the product treated as usual gave 2.8 g. 1-(3-benzyloxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-HCl (IV), prisms, m. 203-5¡ã (decomposition); the free base, needles, m. 84-6¡ã; picrate, columns, m. 207-9¡ã (MeOH). The free base (from 250 mg. IV) in MeOH and 1 ml. MeI refluxed 2 hrs., the product concentrated, the residue in MeOH at 0¡ã treated dropwise with 500 mg. NaBH₄ in MeOH, heated 1 hr. at 50¡ã, the solution concentrated, the residue in H₂O made alk. and extracted with Et₂O gave 1-(3-benzyloxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (V), oil, which yielded 220 g. picrate, columns, m. 164-5¡ã (decomposition). V (870 mg.) in 40 ml. 20% HCl refluxed 30 min., the product washed with Et₂O, made alk. with NaHCO₃, extracted with CHCl₃, stirred with 10% NaOH, the NaOH layer treated with NH₄Cl and NH₄OH, and extracted with CHCl₃ yielded 57% 1-(3-HOC₆H₄CH₂) analog (VI) of V, columns, m. 136-7.5¡ã; picrate, columns, m. 180-3¡ã (decomposition). VI (100 mg.) in MeOH and CH₂N₂ (from 1 g. nitrosomethylurea) in Et₂O kept 2 days at room temperature, the solution concentrated, the residue in dilute HCl made alk. with NaOH and the product extracted with Et₂O gave 80 mg. 1-(3-MeOC₆H₄CH₂) analog (VII) of V, oil; VII.HCl.0.5H₂O, needles, m. 198-201¡ã; VII.HI, needles, m. 227-30¡ã (decomposition). K (60 mg.) in 6 ml. MeOH heated with 450 mg. dl-VI and the MeOH removed gave the K salt of dl-VI, which treated with dl-1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (from 1050 mg. of its picrate, m. 183-3.5¡ã) in Et₂O, the Et₂O removed, the residue with 75 mg. Cu and 60 mg. Cu(OAc)₂ heated 30 min. at 180-5¡ã, 25 min. at 185-95¡ã, and 10 min. at 105-200¡ã, cooled, the product extracted with Et₂O, the phenolic base removed by washing with 2% KOH, and the nonphenolic base refined by chromatographic method yielded 160 mg. dl-3,4′-bis(2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolylmethyl)diphenyl ether (VIII), oil; VIII.2(CO₂H)₂.H₂O, needles, m. 185-8¡ã (decomposition) (MeOH-Me₂CO); styphnate, VIII.2(C₆H₃O₈N₃), prisms, m. 143-6¡ã (decomposition) (Me₂CO-EtOH).

Yakugaku Zasshi published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C9H8BNO2, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sigfridsson, Kalle published the artcilePreformulation investigation and challenges; salt formation, salt disproportionation and hepatic recirculation, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is European Journal of Pharmaceutical Sciences (2017), 262-272, database is CAplus and MEDLINE.

A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was to evaluate the potential of the further development of the compound Fundamental physicochem. properties and stability of the compound were characterized in solution by liquid chromatog. and NMR and in solid-state by various techniques. The drug itself is a lipophilic acid with tendency to form aggregates in solution The neutral form was only obtained in amorphous form with a glass-transition temperature of approx. 0¡ãC. The intrinsic solubility at room temperature was determined to 0.03 mg/mL. Chem. stability studies of the compound in aqueous solutions showed good stability for at least two weeks at room temperature, except at pH 1, where a slight degradation was already observed after one day. The chem. stability in the amorphous solid-state was investigated during a period of three months. At 25¡ãC/60% relative humidity (RH) and 40¡ãC/75% RH no significant degradation was observed At 80¡ãC, however, some degradation was observed after four weeks and approx. 3% after three months. In an accelerated photostability study, degradation of approx. 4% was observed Attempts to identify a crystalline form of the neutral compound were unsuccessful, however, salt formation with tert-butylamine, resulted in crystalline material. Results from stability tests of the presented crystalline salt form indicated improved chem. stability at conditions whereas the amorphous neutral form degraded.

European Journal of Pharmaceutical Sciences published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C17H29BO2, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia