Tag: M.W=200-250

Seyhan, Serap published the artcileUse of o-phenylenedioxydiacetic acid impregnated in Amberlite XAD resin for separation and preconcentration of uranium(VI) and thorium(IV), Computed Properties of 5411-14-3, the publication is Journal of Hazardous Materials (2008), 152(1), 79-84, database is CAplus and MEDLINE.

The impregnation of o-phenylene dioxydiacetic acid (OPDA) into a polymeric matrix, Amberlite XAD-2000, is reported and was characterized by IR spectroscopy. The amount of attached OPDA to the polymer resin was found to be 1.77 mmol g^-1 resin. The resin was used for the sorption of U(VI) and Th(IV) from aqueous solution This sorbent was capable of preconcg. U(VI) and Th(IV) from weakly acidic or neutral solution The retained metals were eluted sequentially using 0.25 mol L^-1 HCl for U(VI) and 1 mol L^-1 HCl for Th(IV) and determined spectrophotometrically using arsenazo-(III). The capacity of the resin for U(VI) and Th(IV) was found to be 0.121 and 0.113 mmol g^-1, resp. The impregnated resin exhibits a high chem. stability, reusability, and fast equilibration. The method was used for the determination of U(VI) and Th(IV) in synthetic samples and rock samples.

Journal of Hazardous Materials published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H12O5, Computed Properties of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nageswara Rao, N. published the artcileMicrowave promoted catalyst-free benzylic C-H functionalization of methyl quinoline and Michael addition to beta-nitro styrene, Category: catalysis-chemistry, the publication is Tetrahedron Letters (2013), 54(10), 1315-1317, database is CAplus.

A catalyst-free aqueous mediated C-H activation of Me quinolines and addition to various ¦Â-nitro styrenes were executed under microwave irradiation providing 2-(2-aryl-3-nitropropyl)quinolines, e.g., I. Catalyst-free, additive free, simple workup, clean reaction conditions, easy isolation and environmentally benign medium are the best features of the present protocol.

Tetrahedron Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pehlivan, Leyla published the artcileReduction of phosphine oxides to phosphines with the InBr₃/TMDS system, Category: catalysis-chemistry, the publication is Tetrahedron (2012), 68(15), 3151-3155, database is CAplus.

An efficient method for the reduction of phosphine oxide derivatives into their corresponding phosphines is described. The system InBr₃/TMDS allows the reduction of different secondary and tertiary phosphine oxides as well as aliphatic and aromatic phosphine oxides.

Tetrahedron published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sandrock, Paul B. published the artcileIsopropyl 2,4,6-triisopropylphenyl sulfone: an aryl sulfone with unusual atom deviations from the aromatic least-squares plane, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Acta Crystallographica, Section E: Structure Reports Online (2004), 60(4), o544-o546, database is CAplus.

Iso-Pr 2,4,6-triisopropylphenyl sulfone, C₁₈H₃₀O₂S, (I), was synthesized for the 1st time. Crystallog. data are given. In spite of the bulky iso-Pr substituents on both ortho positions, crystalline (I) does not exhibit rotational disorder of the iso-Pr group bonded to the sulfonyl. In contrast, the corresponding bromo- and chloroisopropyl groups of crystalline aryl sulfones possessing much smaller di-ortho-Me substituents display striking rotational disorder. While the aryl rings of the latter compounds are essentially planar, considerable atom deviation from the aromatic least-squares plane of (I) was observed None of the intra- or intermol. distances between the Me C atoms of the sulfonylisopropyl group and those of the two ortho-iso-Pr groups of (I) is shorter than the sum of their van der Waals radii, making it unlikely that they would interfere with the rotation of the ¦Á-iso-Pr group prior to crystallization

Acta Crystallographica, Section E: Structure Reports Online published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jian-Yuan published the artcilePalladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis, Application of 4-(Phenoxymethyl)benzoic acid, the publication is Bioconjugate Chemistry (2019), 30(8), 2209-2215, database is CAplus and MEDLINE.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Bioconjugate Chemistry published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Application of 4-(Phenoxymethyl)benzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mohamadi, Ali published the artcileBrightly Luminescent and Kinetically Inert Lanthanide Bioprobes Based on Linear and Preorganized Chelators, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Bioconjugate Chemistry (2016), 27(10), 2540-2548, database is CAplus and MEDLINE.

The synthesis, photophys. properties, and kinetic stability of a series of water-soluble, highly emissive Tb(III) and Eu(III) complexes featuring triethylenetetraamine hexaacetic acid (TTHA) and cyclohexyl triethylenetetraamine hexaacetic acid (cyTTHA) chelator scaffolds and carbostyril sensitizers are reported. The unique and modular design of the chelators gives rise to striking quantum yields of emission in aqueous solutions (up to 54%) as well as the characteristic lanthanides’ photophys. properties (long excited-state lifetimes, large effective Stokes shifts, and narrow emission peaks). Furthermore, the preorganized chelators (L3, L4, and L6) bind metal within minutes at ambient temperature yet exhibit substantial resistance to transchelation in the presence of a challenge solution (EDTA, 1 mM). Moreover, the Eu(III) complex of L4 remains stably luminescent in HeLa cells over hours, demonstrating the suitability of these compounds for live-cell imaging applications. Representative chelators suitable for derivatization and protein bioconjugation were also prepared that were functionalized with clickable azide and alkyne moieties, biotin, and trimethoprim (TMP). With exceptional long-wavelength brightness, enhanced kinetic inertness, and an adaptable synthetic route, the reported lanthanide complexes are promising probes and labels for time-gated bioanal., biosensing, and optical microscopy.

Bioconjugate Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mohamadi, Ali published the artcileEfficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, tert-butyl protected TTHA/Cy-TTHA, Synthetic Route of 140-28-3, the publication is Tetrahedron Letters (2017), 58(15), 1441-1444, database is CAplus and MEDLINE.

Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from com. available starting materials in ?62% and 47% overall yields, resp. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, tert-butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators’ carboxylic acids.

Tetrahedron Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Synthetic Route of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

McDonagh, Anthony W. published the artcileSynthesis and Evaluation of Bifunctional [2.2.2]-Cryptands for Nuclear Medicine Applications, Related Products of catalysis-chemistry, the publication is Inorganic Chemistry (2021), 60(13), 10030-10037, database is CAplus and MEDLINE.

For the first time, synthesis of bifunctional [2.2.2]-cryptands (CRYPT) and demonstration of radiolabeling with lead(II) (Pb²⁺) isotopes are disclosed herein. The synthesis is convenient and high-yielding and gives access to three distinct bifunctional handles (azide (-N₃), isothiocyanate (-NCS), and tetrazine (-Tz)) that can enable the construction of radioimmunoconjugates for targeted and pretargeted therapy. Proof-of-principle CRYPT radiolabeling was successful with lead-203 ([²⁰³Pb]Pb²⁺) and demonstrated complexation efficiency superior to that of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and efficiency comparable to that of the current industry standard TCMC (1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoylmethyl)-cyclododecane). In vitro human serum stability assays demonstrated excellent [²⁰³Pb]Pb-CRYPT stability over 72 h (91.7 ¡À 0.56%; n = 3). [²⁰³Pb]Pb-CRYPT-radioimmunoconjugates were synthesized from the corresponding CRYPT-immunoconjugate or by conjugating [²⁰³Pb]Pb-Tz-CRYPT to transcyclooctene modified trastuzumab (TCO-trastuzumab) via the inverse electron-demand Diels-Alder (IEEDA) reaction. This investigation reveals the potential for CRYPT ligands to become new industry standards for therapeutic and diagnostic radiometals in radiopharmaceutical elaboration.

Inorganic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Al-Horani, Rami A. published the artcilePotent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold, Application In Synthesis of 16909-09-4, the publication is European Journal of Medicinal Chemistry (2012), 771-783, database is CAplus and MEDLINE.

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing effective and safe anticoagulants. Although a large number of FXa inhibitors have been studied, each can be classified as either possessing a highly flexible or a rigid core scaffold. The authors reasoned that an intermediate level of flexibility would provide high selectivity for FXa, considering that its active site is less constrained in comparison to thrombin and more constrained as compared to trypsin. They studied several core scaffolds including 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid for direct FXa inhibition. Using a genetic algorithm-based docking and scoring approach, a promising candidate I was identified, synthesized, and found to inhibit FXa with a K_i of 28 ¦ÌM. Optimization of derivative I resulted in the design of a potent dicarboxamide II, which displayed a K_i of 135 nM. Dicarboxamide II displayed at least 1852-fold selectivity for FXa inhibition over other coagulation enzymes and doubled PT and aPTT of human plasma at 17.1 ¦ÌM and 20.2 ¦ÌM, resp., which are comparable to those of clin. relevant agents. Dicarboxamide II is expected to serve as an excellent lead for further anticoagulant discovery.

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Badawi, A. M. published the artcileSurface and biological activity of some novel cationic surfactants, Application of Dodecylamineacetate, the publication is Journal of Surfactants and Detergents (2007), 10(4), 243-255, database is CAplus.

In this study, steps were taken toward the development of bactericidal and fungicidal synthetic cationic surfactants by reacting decyl-, dodecyl- or tetradecylamine with acetic or hydrochloric acid to produce a series of amine salts which consequently converted to copper or cobalt cationic complexes via complexing the first series compounds with copper (II) or cobalt (II) ions. Surface properties such as interfacial tension and emulsifying power of these surfactants were investigated. The surface parameters including critical micelle concentration (CMC), maximum surface excess (¦£_max) and min. surface area (A_min) were studied. Free energy of micellization (¦¤G^o_mic) and adsorption (¦¤G^o_ads) were calculated The antimicrobial activity was determined via the inhibition zone diameter of the prepared compounds, which measured against five strains of a representative group of microorganisms. FTIR spectra, elemental anal. and H¹ NMR spectrum were performed to confirm compound structure and purity.

Journal of Surfactants and Detergents published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Application of Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia