Tag: M.W=200-250

Wang, Da-Wei published the artcileAn Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors, Computed Properties of 163839-73-4, the publication is Journal of Agricultural and Food Chemistry (2016), 64(47), 8986-8993, database is CAplus and MEDLINE.

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. To search for novel HPPD inhibitors, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using of N,N’-Carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH₂Cl₂. A total of 58 triketone compounds were prepared in good to excellent yields. Some of the synthesized compounds displayed potent Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one (I) displayed high, broad-spectrum and post-emergent herbicidal activity at the rate of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, I showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that I might have the potential as herbicide for the weed control in maize and canola fields. I is the first HPPD inhibitor showing good crop safety towards canola.

Journal of Agricultural and Food Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C15H12O8, Computed Properties of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Xinfei published the artcileAerobic Oxidation of Benzylic sp³ C-H Bonds through Cooperative Visible-Light Photoredox Catalysis of N-Hydroxyimide and Dicyanopyrazine, Formula: C13H10F2, the publication is Asian Journal of Organic Chemistry (2017), 6(4), 422-425, database is CAplus.

A visible-light-driven cooperative catalysis between dicyanopyrazine-derived chromophore (DPZ) and N-hydroxyimide has been developed. Under irradiation with a low-energy and operationally convenient visible light, the cooperative catalytic system could facilitate the aerobic oxygenation of a series of benzylic sp³ C-H bonds through a photoredox pathway. The method provides a novel approach to access valuable carbonyls from benzylic methylenes and benzylic alcs. in moderate to excellent yields (up to 93 %).

Asian Journal of Organic Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Formula: C13H10F2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Song, Liping published the artcileFluorine-containing furan derivatives from the Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate with ¦Â-nitrostyrenes, Product Details of C10H11NO4, the publication is Synlett (2010), 830-834, database is CAplus.

Et 4,4,4-trifluoro-3-oxobutanoate reacted with nitrostyrenes in the presence of Et₃N to afford Et 5-(hydroxyimino)-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates along with a small amount of Et 2-hydroxy-5-imino-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates, e.g., I. Treatment of Et 5-(hydroxyimino)-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates with 1.2 equiv of TsOH in t-BuOH, afforded Et 2-hydroxy-5-imino-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates in good yields. However, Et 2-ethoxy or 2-methoxy-5-oxo-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates were obtained as major products in EtOH or MeOH along with a small amount of Et 2-hydroxy-5-imino-4-aryl-2-(trifluoromethyl)-2,5-dihydrofuran-3-carboxylates.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C14H31NO2, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Jianfeng published the artcilePreparation and acidic dissociation constants determination of phenylenedioxybis(acetic acid), Product Details of C10H10O6, the publication is Huaxue Shijie (2002), 43(3), 135-137, database is CAplus.

Three types of phenylenedioxybis(acetic acid) were prepared by reacting dihydroxybenzene with chloroacetic acid in an alkali solution Controlling the pH value of the reaction system and applying a new self-sealing apparatus, high yield and selectivity were obtained. The acid dissociation constants of the samples were obtained for the first time by elec. potential titration A regression method was adopted in the data processing, which made the results more precise and reliable. CNDO/2 quantum chem. calculation method was used to explain the results of acid dissociation constant measurements.

Huaxue Shijie published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C7H10O4, Product Details of C10H10O6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Ping published the artcileEncouraging progress in the ¦Ø-aspartylation of complex oligosaccharides as a general route to ¦Â-N-linked glycopolypeptides, Formula: C9H12O3S, the publication is Journal of the American Chemical Society (2011), 133(5), 1597-1602, database is CAplus and MEDLINE.

Described herein is a method for the joining of complex peptides to complex oligosaccharides via an N-linkage. The ¦Ø-aspartylation is conducted by coupling fully deprotected glycosylamine with a peptide containing a unique thioacid at the ¦Ø-aspartate carboxyl. In the presence of HOBT, under conditions that, in principle, allow for oxidation, complex components are combined in encouraging yields to produce structurally and stereochem. defined N-linked glycopolypeptides wherein the carbohydrate domain can be quite complex. Various mechanisms for oxidative coupling are proposed.

Journal of the American Chemical Society published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H8O4, Formula: C9H12O3S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Xia published the artcile3-D supramolecular frameworks assembled by lanthanide binuclear molecules based on 1,2-phenylenedioxydiacetic acid and 1,10-phenanthroline, Computed Properties of 5411-14-3, the publication is Inorganic Chemistry Communications (2008), 11(7), 779-782, database is CAplus.

[Ln₂(PDOA)₃(phen)₂(H₂O)₂]¡¤2H₂O (Ln = Eu (1), Tb (2), and Dy (3); H₂PDOA = 1,2-phenylenedioxydiacetic acid; phen = 1,10-phenanthroline) were synthesized and structurally characterized by single crystal x-ray diffraction methods. The three complexes are all binuclear mols. The two Ln(III) centers are linked by only one PDOA ligand through its two bidentate-chelating carboxylate groups. PDOA also acts as a terminal ligand using one carboxylate oxygen and ether oxygen atoms to chelate the Ln(III) ion. 3-Dimensional supramol. frameworks are built up by the hydrogen bonds and ¦Ð-¦Ð stacking interactions. The fluorescent spectra of the three complexes show the characteristic emission of the Eu(III) for 1, Tb(III) for 2, and Dy(III) for 3, resp.

Inorganic Chemistry Communications published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Computed Properties of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qiao, Jingxin published the artcileSARS-CoV-2 M^pro inhibitors with antiviral activity in a transgenic mouse model, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Science (Washington, DC, United States) (2021), 371(6536), 1374-1378, database is CAplus and MEDLINE.

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. The main protease (M^pro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing M^pro inhibitors derived from either boceprevir or telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 M^pro activity in vitro, with 50% inhibitory concentration values ranging from 7.6 to 748.5 nM. The cocrystal structure of M^pro in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a transgenic mouse model of SARS-CoV-2 infection, oral or i.p. treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats.

Science (Washington, DC, United States) published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Jing published the artcileCobalt-catalyzed oxidative arylmethylation of phosphorylamides, Recommanded Product: Bis(4-fluorophenyl)methane, the publication is Tetrahedron (2018), 74(35), 4558-4568, database is CAplus.

A cobalt-catalyzed strategy for N-arylmethylation of phosphorylamides was herein achieved with the assistance of azodiisobutyronitrile as the radical initiator and di-tert-Bu peroxide as the oxidant. Both methylarenes and diaryl methanes were compatible under the oxidative conditions, expressing broad substrate scope (51 examples) and high efficiency (up to 87% yield).

Tetrahedron published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C24H29N5O3, Recommanded Product: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Hao published the artcileSynthesis and herbicidal activity of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives, HPLC of Formula: 1798-04-5, the publication is Youji Huaxue (2015), 35(1), 159-166, database is CAplus.

In order to find new herbicidal leading compounds, a series of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives were designed and synthesized via the strategy of linking active sub-structures which are chlorophthalim and phenoxy carboxylic ester. The target compounds were synthesized from starting material 2-chloro-4-fluoro-5-nitrophenol in four steps, and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay results indicated that most compounds exhibited excellent herbicidal activities at 1,500 g/ha in both pre- and post-emergence treatments against Abutilon theophrasti and Amaranthus retroflexus. On the basis of advanced screening tests, compound 6d exhibited 100% inhibitory effect against Abutilon theophrasti and Amaranthus retroflexus at 750 g/ha, compounds 7a and 7i were much more effective against Abutilon theophrasti than com. acifluorfen with 80%-86% inhibitory activity at 22.5 g/ha.

Youji Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H2F12NiO4, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Dong published the artcileCopper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters, HPLC of Formula: 1798-04-5, the publication is Organic Letters (2022), 24(28), 5197-5202, database is CAplus and MEDLINE.

A method to produce (Z)-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF₃ was reported. This synthetic method used inexpensive and easy-to-handle TMSCF₃. It employed a com. available CuCl catalyst to transform a broad range of carboxylic acids into versatile (Z)-trifluoromethyl enol esters with good regio- and stereoselectivity. This protocol allowed the concise synthesis of highly functionalized (Z)-trifluoromethyl enol esters directly from carboxylic acids.

Organic Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia