Tag: M.W=200-250

Prakash, G. K. Surya published the artcileN,N-Dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate: A versatile electrophilic difluoromethylating reagent, Product Details of C14H23N, the publication is Journal of Fluorine Chemistry (2011), 132(10), 792-798, database is CAplus.

Over the past decade, sulfur-based fluoromethyl containing compounds have been exhaustively investigated as versatile fluoroalkylating reagents by our research laboratory as well as many others. Lately, we have designed a novel electrophilic difluoromethylating protocol employing in situ prepared N,N-dimethyl-S-difluoromethyl-S-phenylsulfoximinium salt. The present reagent provides excellent reactivity toward a broad spectrum of nucleophilic species (N-, P-, S-, and O-nucleophiles) to yield the corresponding difluoromethylated products with high efficacy under mild conditions. Addnl. studies have been performed to elucidate the mechanistic fundamentals of the reactions.

Journal of Fluorine Chemistry published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Product Details of C14H23N.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Li-Biao published the artcileStereospecific Addition of H-P Bond to Alkenes: A Simple Method for the Preparation of (R_P)-Phenylphosphinates, Related Products of catalysis-chemistry, the publication is Journal of Organic Chemistry (2005), 70(24), 10121-10123, database is CAplus and MEDLINE.

Functionalized chiral at phosphorus optically pure (R_P)-alkylphenylphosphinates were prepared by stereospecific radical or base-catalyzed additions of the easily available (R_P)-menthyl phenylphosphinate to 1-alkenes. Addition of (R_P)-(RO)PO(H)Ph [1, R = (-)-menthyl] to alkenes CH₂:CHR¹ gave (R_P)-(RO)PO(CH₂CH₂R¹)Ph [2a, 2c–l; R¹ = C₆H₁₃, (CH₂)₄OH, OBu, SPh, PPh₂, POPh₂, PO(OEt)₂, Si(OEt)₃, SnBu₃, CH₂POPh₂, 3-cyclohexen-1-yl], the same reaction conditions applied to internal alkenes gave (R_P)-(RO)POR²Ph (2m–r; R² = 3-tetrahydrofuranyl, 3-tetrahydropyranyl, CH₂CHMeOAc, 2-norbornyl, cyclohexyl, cyclopentyl). Stereospecific Michael addition of 1 to electroneg. alkenes CH₂:CHR³ was achieved in the presence of R⁴OMgCl (R⁴ = Et, ⁱPr, ^tBu, (-)-menthyl) as base catalysts, affording (R_P)-(RO)PO(CH₂CH₂R³)Ph [2h, 2s,t; R³ = PO(OEt)₂, CN, CO₂Me]. Absolute phosphorus configuration of the products 2 was determined by addition of 1 with (R_P)-(RO)PO(CH:CH₂)Ph, which gave (R_P,R_P)-(RO)POPhCH₂CH₂POPh(OR).

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Chen-Ran published the artcileOrganocatalytic silyl transfer from silylborane to nitroalkenes for the synthesis of ¦Â-silyl nitroalkanes and ¦Â-silyl amines, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(50), 7862-7865, database is CAplus and MEDLINE.

The silylation of a wide array of nitroalkenes is achieved by organocatalysts in yields up to 93%. The reaction is carried out in a toluene/water biphasic solvent under operationally simple conditions. Reduction of the nitro group provides efficient access to functionalized ¦Â-silyl amines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Yongwei published the artcileSynthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(15), 4471-4475, database is CAplus and MEDLINE.

On the basis of the active site of lanosterol 14¦Á-demethylase from Candida albicans (CACYP51), a series of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one derivatives I (R = 4-F, 2-F, 4-Cl, 3-Cl, 2,4-Cl₂, 3-Br, 2-Br, 4-MeO, 3-MeO, 4-OCF₃, 4-Me, 3-Me, 2-Me, 3,4-Me₂, 2,4-Me₂, 4-nPr, 4-Bu, 4-pentyl, 4-hexyl, 4-tBu, 4-iPr) and II (R = 4-F, 3-F, 2-F, 4-Cl, 3,4-Cl₂, 4-Br, 3-Br, 4-Me, 2,3-Me₂, 4-MeO, 3,4-(MeO)₂,2,4-(MeO)₂, 4-NO₂, 3-NO₂, 2-NO₂, 3-CN) were synthesized as fluconazole analogs. Results of the preliminary antifungal tests against eight human pathogenic fungi in vitro showed that these compounds exhibited activities to some extent, and some displayed excellent antifungal activities against C. albicans than reference drug fluconazole. Flexible mol. docking was used to analyze the structure-activity relationships (SARs) of the target compounds The designed compounds interact with CACYP51 through hydrophobic, van der Waals and hydrogen-bonding interactions.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Guan published the artcileDecorating an individual living cell with a shell of controllable thickness by cytocompatible surface initiated graft polymerization, Quality Control of 5411-14-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(37), 4677-4680, database is CAplus and MEDLINE.

Surface engineering of individual living cells is a promising field for cell-based applications. However, engineering individual cells with controllable thickness by chem. methods has been rarely studied. This article describes the development of a new cytocompatible chem. strategy to decorate individual living cells. The thicknesses of the crosslinked shells could be conveniently controlled by the irradiation time, visible light intensity, or monomer concentration Moreover, the lag phase of the yeast cell division was extended and their stability against lysis was improved, which could also be tuned by controlling the shell thickness.

Chemical Communications (Cambridge, United Kingdom) published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C16H12O, Quality Control of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Y. published the artcileHydrothermal synthesis, structure, and properties of a novel 2D stair-like zinc coordination polymer with benzene-1,2-dioxyacetate, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Russian Journal of Coordination Chemistry (2010), 36(6), 452-457, database is CAplus.

The hydrothermal reaction of Zn(CH₃COOH)₂¡¤6H₂O with benzene-1,2-di(oxyacetic acid) (H₂BDOA) and 1,4-bis(imidazol-1-yl)butane (Bimb) yields a novel 2D zinc coordination polymer, [Zn(BDOA)(Bimb)]¡¤3H₂O_n, in which the Bimb ligands link the 1D Zn-BDOA chains into two kinds of 1D ladder-like structure to construct a 2D stair-like structure. It exhibits intense blue photoluminescence upon photoexcitation.

Russian Journal of Coordination Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Meizi published the artcileExploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Chinese Chemical Letters (2018), 29(9), 1375-1378, database is CAplus.

Allatostatins (ASTs), a family of insect neuropeptide, can inhibit juvenile hormone (JH) biosynthesis by the corpora allata (CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators (IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 (I) possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro (IC₅₀: 0.09 ¦Ìmol/L) in our previous studies. In the present work, two series of I analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with logP value over 2.0 exhibited good activity, which indicated the hydrophobicity is important to the bioactivity. Three dimension quant. structure-activity relationship (3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog (II) (IC₅₀: 0.08 ¦Ìmol/L) exhibited similar inhibitory activity to the lead B1, but its synthetic route was simpler than B1. Therefore, II could be used as a new lead compound for the discovery ecofriendly IGRs.

Chinese Chemical Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C2H4ClNO, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Chao published the artcileSynthesis, crystal structure and catalytic properties of novel Zn-N metal complexes based on ethylenediamine derivatives, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Rengong Jingti Xuebao (2015), 44(1), 287-293, database is CAplus.

Two novel Zn-N metal complexes [Zn(OAc)₂L] (L = N,N-dimethylethylenediamine (1), N,N’-dibenzylethylenediamine (2)) were synthesized with N,N-dimethylethylenediamine and N,N’-dibenzylethylenediamine as ligand, and the structures were characterized and analyzed by ¹H NMR, IR, elemental anal. and x-ray single crystal diffraction. The catalytic properties of the complexes in Henry reaction of aromatic aldehydes with nitromethane and the influences of the reaction conditions were studied, and the applicable scope of aromatic aldehydes in Henry reaction with complex as catalyst is discussed. The complexes can efficiently catalyze the Henry reaction of different aromatic aldehydes with nitromethane under the conditions as follows: methanol as solvent, complex 1 as catalyst mediated by equimolar triethylamine, and catalyst amount for 25 mol%.

Rengong Jingti Xuebao published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Chao published the artcileSynthesis of structurally diverse diarylketones through the diarylmethyl sp³ C-H oxidation, Application In Synthesis of 457-68-1, the publication is Tetrahedron Letters (2014), 55(32), 4458-4462, database is CAplus.

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of com. available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on ¹⁸O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

Tetrahedron Letters published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Application In Synthesis of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sena, Arlene C. published the artcileA systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is BMC Infectious Diseases (2015), 479/1-479/15, database is CAplus and MEDLINE.

Syphilis remains a global public health threat and can lead to severe complications. In addition to resolution of clin. manifestations, a reduction in nontreponemal antibody titers after treatment is regarded as “proof of cure.” However, some patients manifest < 4-fold decline (“serol. non-response”) or persistently pos. nontreponemal titers despite an appropriate decline (“serofast”) that may represent treatment failure, reinfection, or a benign immune response. To delineate these treatment phenomena, we conducted a systematic review of the literature regarding serol. outcomes and associated factors among HIV-infected and -uninfected subjects. Six databases (PubMed, Embase, CINAHL, Web of Science, Scopus, and BIOSIS) were searched with no date restrictions. Relevant articles that evaluated serol. treatment responses and correlates of serol. cure (¡Ý fourfold decline in nontreponemal titers) were included. We identified 1693 reports in the literature, of which 20 studies met selection criteria. The median proportion of patients who had serol. non-response was 12.1 % overall (interquartile range, 4.9-25.6), but varied depending on the time points after therapy. The serofast proportion could only be estimated from 2 studies, which ranged from 35.2-44.4 %. Serol. cure was primarily associated with younger age, higher baseline nontreponemal titers, and earlier syphilis stage. The relationship between serol. cure and HIV status was inconsistent; among HIV-infected patients, CD4 count and HIV viral load was not associated with serol. cure. Serol. non-response and the serofast state are common syphilis treatment outcomes, highlighting the importance of determining the immunol. and clin. significance of persistent nontreponemal antibody titers after therapy.

BMC Infectious Diseases published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C9H7NO3, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia