Tag: M.W=200-250

Kahraman, M. Vezir published the artcileFlame retardance of epoxy acrylate resin modified with phosphorus containing compounds, Quality Control of 4141-48-4, the publication is Progress in Organic Coatings (2004), 51(3), 213-219, database is CAplus.

In this work, UV-radiation curing of allyldiphenyl phosphine oxide (ADPPO) and 4,4′-bis(allyloxyphenyl) Ph phosphine oxide (DAPPO) monomers with epoxy acrylate resin in the presence of a photoinitiator was studied and their flame-retardant performance compared with pure epoxy acrylate film. The structures of allyl functional phosphorus compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR and all spectra were consistent with the expected structures. The polymerization behavior of both allyl functional monomers was followed in detail by monitoring the disappearance of acrylate and allyl groups by real-time IR spectroscopy. The reactivity of DAPPO monomer is higher than ADPPO. In the case of ADPPO, chain transfer to monomer basically predominates. In each monomer, a tack free coating was obtained immediately upon irradiation The addition of DAPPO leads to an improvement of the thermal and flame-retardant properties of the polymeric films. Thermal gravimetric anal. of DAPPO containing polymeric films gave higher char yield compared with UV-cured pure epoxy acrylate resin.

Progress in Organic Coatings published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Quality Control of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ozcan, Sevil published the artcileOxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors, Synthetic Route of 163839-73-4, the publication is Journal of Medicinal Chemistry (2013), 56(10), 3783-3805, database is CAplus and MEDLINE.

Screening of the 50 000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide I (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC₅₀ = 0.60 ¦ÌM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). LC-MS/MS and dialysis show that I is a noncovalent and rapidly reversible CT-L inhibitor. Focused library synthesis provided II (PI-1840) with CT-L activity (IC₅₀ = 27 nM). Detailed SAR studies indicate that the amide moiety and the two Ph rings are sensitive toward modifications. Hydrophobic residues, such as Pr or Bu in the para position (not ortho or meta) of the A-ring and a m-pyridyl group as B-ring, significantly improve activity. Compound II (IC₅₀ = 0.37 ¦ÌM) is more potent than I (IC₅₀ = 3.5 ¦ÌM) at inhibiting CT-L activity in intact MDA-MB-468 human breast cancer cells and inhibiting their survival. The activity of II warrants further preclin. investigation of this class as noncovalent proteasome inhibitors.

Journal of Medicinal Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Synthetic Route of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ozcan, Sevil published the artcileOxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Medicinal Chemistry (2013), 56(10), 3783-3805, database is CAplus and MEDLINE.

Screening of the 50 000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide I (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC₅₀ = 0.60 ¦ÌM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). LC-MS/MS and dialysis show that I is a noncovalent and rapidly reversible CT-L inhibitor. Focused library synthesis provided II (PI-1840) with CT-L activity (IC₅₀ = 27 nM). Detailed SAR studies indicate that the amide moiety and the two Ph rings are sensitive toward modifications. Hydrophobic residues, such as Pr or Bu in the para position (not ortho or meta) of the A-ring and a m-pyridyl group as B-ring, significantly improve activity. Compound II (IC₅₀ = 0.37 ¦ÌM) is more potent than I (IC₅₀ = 3.5 ¦ÌM) at inhibiting CT-L activity in intact MDA-MB-468 human breast cancer cells and inhibiting their survival. The activity of II warrants further preclin. investigation of this class as noncovalent proteasome inhibitors.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sifri, Renee J. published the artcilePhotocontrolled cationic degenerate chain transfer polymerizations via thioacetal initiators, Category: catalysis-chemistry, the publication is Polymer Chemistry (2020), 11(40), 6499-6504, database is CAplus.

Recent developments in photocontrolled polymerizations have facilitated the development of previously inaccessible materials. While photocontrolled radical polymerizations have been extensively studied, related processes involving cationic polymerizations are underexplored and limited to RAFT processes. In this study, we disclose a visible light, temporally controlled cationic polymerization of vinyl ethers utilizing thioacetals and a photoredox catalyst. We demonstrate a broad scope of thioacetal initiators that achieve a well-controlled polymerization by recapping propagating chains via photocatalyst turnover in combination with a degenerate chain transfer process through sulfonium intermediates. Furthermore, we show that a photocatalyst with a more reducing ground state reduction potential allows for enhanced control and excellent temporal regulation of polymerization

Polymer Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C16H20N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fleck, Christian published the artcileLocal anaesthetic effectivity and toxicity of fomocaine, five N-free fomocaine metabolites and two chiral fomocaine derivatives in rats compared with procaine, Name: 4-(Phenoxymethyl)benzoic acid, the publication is Arzneimittel-Forschung (2001), 51(6), 451-458, database is CAplus.

Until now, no optimal local anesthetic drug with long lasting effect and low toxicity has been developed. Fomocaine (CAS 17692-39-6), introduced in the German extrapharmacopoeia (DAC) in 1979, is a local anesthetic, which is largely in accordance with these aspects. Now the basic ether fomocaine, its metabolites O/Se 9 (CAS 3006-96-0), O/Se 10 (CAS 31719-76-3), O/Se 11, O/Se 12 (CAS 64264-21-7) and M5 and its chiral derivatives O/G 3 and O/G 5 were compared with procaine (CAS 59-46-1) and characterized more in detail in rats. The metabolism of fomocaine was investigated earlier with ¹⁴C-fomocaine in rats and beagle dogs. Rac-O/G 3 and Rac-O/G 5 could be separated into the enantiomers via the diastereomeric salts. Based on standard methods for the testing of the local anesthetic effects (estimation of infiltration and conduction anesthesia in rat tail, measurement of corneal anesthesia) and using a couple of tests characterizing the side effects and toxicity of local anesthetic (paresis of the N. ischiadicus, tissue irritation, determination of the approximative i.p. LD₅₀) it can be concluded that: (a) the very good surface anesthesia caused by fomocaine could be stated, but, as expected, concerning conduction anesthesia, procaine is better qualified for clin. use. (b) Fomocaine is much more effective in conduction and surface anesthesia than its chiral derivatives O/G 3 and O/G 5. (c) Differences between the two enantiomers of the O/G-substances have been found, but these little discrepancies are without practical relevance. In the case of O/G 5, agonistic effects of both enantiomers could be shown. (d) Fomocaine undergoes extensive biotransformation with subsequent formation of 14 metabolites. Five of them (O/Se 9-O/Se 12; M5) are N-free and do not show any pharmacol. activity. (e) Compared to other local anesthetics, fomocaine is relatively non-toxic (nearly no tissue irritation, high approximative LD₅₀), however, surprisingly the toxicity of the reference substance procaine has been found to be lower after i.p. administration instead of i.v. administration in comparison with fomocaine.

Arzneimittel-Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Name: 4-(Phenoxymethyl)benzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maeta, Naoya published the artcileRadical-Cation Vinylcyclopropane Rearrangements by TiO₂ Photocatalysis, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of Organic Chemistry (2020), 85(10), 6551-6566, database is CAplus and MEDLINE.

Radical cation vinylcyclopropane rearrangements by TiO₂ photocatalysis in lithium perchlorate/nitromethane solution are described. The reactions are triggered by oxidative single electron transfer, which is followed by immediate ring-opening of the cyclopropanes to generate distonic radical cations as unique reactive intermediates. This approach can also be applied to vinylcyclobutane, leading to the construction of six-membered rings. A stepwise mechanism via distonic radical cations is proposed based on preliminary mechanistic studies, which is supported by d. functional theory calculations

Journal of Organic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Shinae published the artcileAsymmetric domino aza-Michael-Michael reaction of o-N-protected aminophenyl ¦Á,¦Â-unsaturated ketones: construction of chiral functionalized tetrahydroquinolines, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Tetrahedron (2014), 70(34), 5114-5121, database is CAplus.

The diastereo- and enantioselective synthesis of 2,3,4-trisubstituted tetrahydroquinolines e. g., I, has been developed through organocatalytic domino aza-Michael-Michael reaction of o-N-tosylaminophenyl ¦Á,¦Â-unsaturated ketones with nitroalkenes. This useful and simple domino process afforded diverse highly functionalized tetrahydroquinolines, some of which are not easily accessible using other methodologies, in good yields and with excellent diastereo- and enantioselectivities (up to >30:1 dr, >99% ee).

Tetrahedron published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pickel, Thomas C. published the artcileSynthesis of Previously Inaccessible Derivatives of 1,4,7-Tri-R-1,4,7-Triazacyclononane, Including Chiral Examples, and a Rapid Synthesis of the HCl Salts of H₃tacn and H₄dtne, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is European Journal of Organic Chemistry (2018), 2018(48), 6876-6889, database is CAplus.

Unsym. triazacyclononanes with one or two tertiary alkyl nitrogen substituents, including nonracemic N-substituted triazacyclononanes, such as I and II, were prepared using the “crab-like” cyclization of N,N’-bis(chloroacetyl)ethanediamines with amines as the key step. Tert-butyl-substituted triazacyclononanes were deprotected with acid to yield triazacyclononane hydrochlorides, including the trihydrochloride of 1,4,7-triazacyclononane and a binucleating N-ethylene bridged derivative The structures of the copper(I) complexes of I and two other triazacyclononanes and the structure of II were determined by X-ray crystallog.

European Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lupp, Amelie published the artcileA synopsis on different homologous series of fomocaine derivatives. In vitro interactions with the cytochrome P450 system, toxicity, and local anesthetic effects in rats., Application of 4-(Phenoxymethyl)benzoic acid, the publication is Arzneimittel Forschung (2007), 57(9), 562-567, database is CAplus.

Fomocaine (CAS 56583-43-6) is a basic ether-type local anesthetic used in dermatol. practice for surface anesthesia. For many years, modifications of the fomocaine mol. have been pursued, e.g. to improve its physicochem. properties and also in view of possible new (systemic) applications, e.g. in the treatment of migraine or as antiarrhythmic. The present paper provides a survey of the investigations undertaken with all the different series of fomocaine derivatives synthesized so far with respect to their in vitro interaction capacity at the cytochrome P 450 system, in vivo toxicity (LD₅₀; paresis of the N. ischiadicus) and local anesthetic effects (conduction anesthesia at the N. ischiadicus; surface anesthesia of the cornea) in rats. The main objective of this systematic comparison of the effects of all these substances was to assess possible basic structure-activity relationships.

Arzneimittel Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Application of 4-(Phenoxymethyl)benzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kaur, Gurpreet published the artcileStudies on thermogravimetric analysis and solvophobic interactions of micellization of Pd (II) complex in non aqueous solvents, Category: catalysis-chemistry, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2013), 25-34, database is CAplus.

The present paper deals with the synthesis and characterization of a Pd (II) metal complex by means of various spectroscopic, thermogravimetric and physicochem. techniques. The Pd metal complex was found to be thermally stable with m.p. at 193 ¡ãC. Thermodn. decomposition parameters and activation energy were obtained using various methods. The micellization behavior of the complex was examined in different alcs. (n = 2-5) and at various temperatures Self assembly of synthesized metallosurfactant resulted in formation of inverted metallomicelles with cmc in range of 0.7-0.8 mM. Thermodynamically micellization process was found to be enthalpy driven. Dynamic redox electrochem. behavior changes from reversible to irreversible process with change of alc. as solvent for different micellar solution The size of Pd inverse’ metallomicelles was found to increase with increase in the hydrophobicity of the solvent. Moreover, the study also takes into account the role of metal ion in modifying the properties of a metallosurfactant.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia