Tag: M.W=200-250

Priyadarshini, S. published the artcileCopper catalyzed cross-coupling reactions of carboxylic acids: an expedient route to amides, 5-substituted ¦Ã-lactams and ¦Á-acyloxy esters, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is RSC Advances (2013), 3(40), 18283-18287, database is CAplus.

A convenient and recyclable catalytic protocol for the synthesis of N,N-di-Me substituted amides, 5-substituted ¦Ã-lactams, and ¦Á-acyloxy ethers from carboxylic acids using CuO nanoparticles and TBHP is described.

RSC Advances published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yun, Jisu published the artcilePalladium-Catalyzed ¦Á-Arylation of Cyclic ¦Â-Dicarbonyl Compounds for the Synthesis of Ca_V1.3 Inhibitors, Application of N1,N2-Dibenzylethane-1,2-diamine, the publication is ACS Omega (2022), 7(16), 14252-14263, database is CAplus and MEDLINE.

Cyclic ¦Á-aryl ¦Â-dicarbonyl derivatives are important scaffolds in medicinal chem. Palladium-catalyzed coupling reactions of haloarenes were conducted with diverse five- to seven-membered cyclic ¦Â-dicarbonyl derivatives including barbiturate, pyrazolidine-3,5-dione, and 1,4-diazepane-5,7-dione. The coupling reactions of various para- or meta-substituted aryl halides occurred efficiently when Pd(t-Bu₃P)₂, Xphos, and Cs₂CO₃ were used under 1,4-dioxane reflux conditions. Although the couplings of ortho-substituted aryl halides with pyrazolidine-3,5-dione and 1,4-diazepane-5,7-dione were moderate, the coupling with barbiturate was limited. Using the optimized reaction conditions, we synthesized several 5-aryl barbiturates as new scaffolds of Ca_V1.3 Ca²⁺ channel inhibitors. Among the synthesized mols., I was the most potent Ca_V1.3 inhibitor with an IC₅₀ of 1.42¦ÌM.

ACS Omega published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C4H5F3N2O3S, Application of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Duperray, Florence published the artcileExcretion of glutamate from Corynebacterium glutamicum triggered by amine surfactants, Category: catalysis-chemistry, the publication is Biochimica et Biophysica Acta, Biomembranes (1992), 1103(2), 250-8, database is CAplus and MEDLINE.

C. glutamicum is used for the industrial production of glutamate. Excretion of the amino acid may be induced by various means. The characteristics of glutamate excretion induced by 2 amine surfactants, dodecylammonium acetate (DA) and dodecyltrimethylammonium bromide (DTA) were analyzed. Addition of these surfactants induced an immediate efflux of internal glutamate. It also induced a perturbation of the energetic parameters of the cell (decrease of ¦¤¦Ì?_H, decrease of the internal ATP concentration). The efflux was not the result of these perturbations: glutamate is taken up by the cells via an ATP-dependent unidirectional active transport system and no efflux took place as a consequence of an artificial decrease of the energetic parameters. In addition, amine surfactants also induced an excretion of other species, in particular potassium. The possibility that the effluxes result from a permeabilization of the lipid bilayer was tested by analyzing the interactions between the surfactants and liposomes.

Biochimica et Biophysica Acta, Biomembranes published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Yan-ping published the artcileI₂-CF₃SO₃H Synergistic Promoted sp³ C-H Bond Diarylation of Aromatic Ketones, Application of 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Organic Letters (2012), 14(20), 5378-5381, database is CAplus and MEDLINE.

An I₂-CF₃SO₃H synergistic promoted sp³ C-H bond diarylation protocol was developed for the synthesis of 2,2-bis(4-(dimethylamino)phenyl)-1-aryl ethanones. Thus, reacting R¹COMe (R¹ = Ph, 4-MeOC₆H₄, 2-thienyl, etc.) with R²C₆H₅ (R² = NMe₂, NEt₂, NPr₂, etc.) in the presence of I₂/CF₃SO₃H/DMSO gave diarylketones I. The reaction performed well in the absence of any metal and ligand. It integrated three reactions with different mechanisms (iodination, Kornblum oxidation, and hydroarylation) in a single reactor.

Organic Letters published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C38H74Cl2N2O4, Application of 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zheng, Chunyang published the artcileSymmetry Breaking and Two-Step Spin-Crossover Behavior in Two Cyano-Bridged Mixed-Valence {Fe^III₂(¦Ì-CN)₄Fe^II₂} Clusters, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Inorganic Chemistry (2019), 58(21), 14316-14324, database is CAplus and MEDLINE.

Two new cyano-bridged mixed-valence {Fe^III₂(¦Ì-CN)₄Fe^II₂} clusters, {[(Tp)Fe^III(CN)₃]₂[Fe^II(Py₂N₂)]₂}¡¤(ClO₄)₂¡¤MeCN¡¤Et₂O (1¡¤MeCN¡¤Et₂O), its solvent-free form (1), and {[(Tp)Fe^III(CN)₃]₂[Fe^II(Me₂Py₂N₂)]₂}¡¤(ClO₄)₂¡¤5MeOH (2¡¤5MeOH), were obtained [Tp = hydrotris(pyrazol-1-yl)borate; N,N’-bis(2-pyridylmethyl)-N,N’-bis(4-X-benzyl)-1,2-ethanediamine, Py₂N₂, X = H; Me₂Py₂N₂, X = Me]. Complexes 1 and 2¡¤5MeOH exhibit gradual thermally induced two-step spin-crossover behavior (SCO) at two Fe^II metal centers, and the transformation of high-spin (HS) to low-spin (LS) Fe^II ions with temperature was confirmed by a combination of x-ray crystallog., variable-temperature Fourier transform IR, variable-temperature magnetic susceptibility, and ⁵⁷Fe Moessbauer spectroscopy. Moreover, complexes 1¡¤MeCN¡¤Et₂O and 1 exhibit a reversible single-crystal-to-single-crystal transformation, and complex 1 undergoes two-step SCO behavior with T_1/2 = 178 and 93 K accompanied by symmetry breaking in the structure. The cyanide-bridged mixed-valence {Fe^III₂(¦Ì-CN)₄Fe^II₂} square cluster exhibits two-step spin-transition behavior, accompanied by symmetry breaking and single-crystal-to-single-crystal transformation.

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C3H3Br2ClO, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Che, Chao published the artcileTricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is ACS Omega (2022), 7(28), 24824-24837, database is CAplus and MEDLINE.

A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramol. hydroamination reaction, and acridinium derivatives were demonstrated to be the optimal catalysts. Addnl., the synthesized tricyclic aza-andrographolide derivatives were found to inhibit human coronavirus with high potency.

ACS Omega published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hernandez-Coronado, Marcela published the artcileSuccessful second outpatient autologous hematopoietic cell transplant for relapsed POEMS syndrome in a patient with coexisting HIV, HBV and syphilis infections during the COVID-19 pandemic, HPLC of Formula: 140-28-3, the publication is Transplant Immunology (2021), 101412, database is CAplus and MEDLINE.

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a multisystem autoinflammatory disease due to an underlying plasma cell disorder that lacks a standard treatment strategy because of its rarity. We report a case of relapsed POEMS syndrome successfully treated with a second ambulatory autologous hematopoietic-cell transplantation (AHCT) after a daratumumab desensitization protocol performed during the coronavirus disease (COVID-19) pandemic in a patient with coexisting human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis infections. He is a 37-yr old Latin-American male who had been treated with radiation, CyBorD regimen, AHCT and bortezomib therapy before being referred to our service. It was decided to administer daratumumab therapy and subsequently perform the transplant. Placement of central venous access, fluid infusion, conditioning regimen with melphalan and previously cryopreserved autograft infusion were carried out in an outpatient basis. Following second AHCT, the patient demonstrated clin., VEGF, hematol. response and remains SARS-CoV-2 infection-free and in POEMS remission with excellent quality-of-life at last follow up (6 mo). We evidenced that thanks to an outpatient transplant program, the best therapeutic modalities can be offered to patients with hematol. malignancies in the context of present or future pandemics. Finally, high-complexity patients with HIV infection should have access to the same treatment strategies as non-infected patients. A second AHCT in the outpatient setting is feasible, safe and highly effective to treat patients with relapsed POEMS syndrome.

Transplant Immunology published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hearn, Brian R. published the artcileStructure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is ChemMedChem (2016), 11(8), 870-880, database is CAplus and MEDLINE.

The integrated stress response (ISR) comprises multiple signaling pathways for detecting and responding to cellular stress that converge at a single event – the phosphorylation of Ser51 on the ¦Á-subunit of eukaryotic translation initiation factor 2 (eIF2¦Á). Phosphorylation of eIF2¦Á (eIF2¦Á-P) results in attenuation of global protein synthesis via the inhibitory effects of eIF2¦Á-P on eIF2B, the guanine exchange factor (GEF) for eIF2. Herein we describe structure-activity relationship (SAR) studies of bis-O-arylglycolamides, first-in-class integrated stress response inhibitors (ISRIB). ISRIB analogs make cells insensitive to the effects of eIF2¦Á-P by activating the GEF activity of eIF2B and allowing global protein synthesis to proceed with residual unphosphorylated eIF2¦Á. The SAR studies described herein support the proposed pharmacol. of ISRIB analogs as binding across a sym. protein-protein interface formed between protein subunits of the dimeric eIF2B heteropentamer.

ChemMedChem published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Zhiguo published the artcileEnantioselective synthesis of 2-aryl-3-nitro-2H-chromenes catalyzed by a bifunctional thiourea, Formula: C10H11NO4, the publication is Synlett (2011), 1262-1264, database is CAplus.

A bifunctional thiourea-catalyzed tandem approach of oxa-Michael-aza-Henry-desulfonamidation was used to synthesize chiral 2-aryl-3-nitro-2H-chromenes. This method provides direct access to the corresponding products in moderate to good yields and enantioselectivities.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H12O6, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shi, Caihua published the artcileActivated release of hexanal and salicylaldehyde from imidazolidine precursors encapsulated in electrospun ethylcellulose-poly(ethylene oxide) fibers, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is SN Applied Sciences (2021), 3(3), 385, database is CAplus.

Hexanal and salicylaldehyde are naturally-occurring antimicrobial volatiles from edible plants known for their efficacy for post-harvest preservation of fruits and vegetables. Due to their volatility and susceptibility to oxidation, these volatiles must be encapsulated within a carrier to control their release, especially when applied in modified atm. and active packaging applications. In this study, salicylaldehyde precursor (SP; 1,3-dibenzylethane-2-hydroxyphenyl imidazolidine) and hexanal precursor (HP) were synthesized through a Schiff base reaction between these aldehydes and N,N’-dibenzylethane-1,2-diamine. The structure of SP was confirmed using NMR and attenuated total reflection-Fourier transform IR (FTIR) spectroscopies. SP and HP, sep. and in combinations, were encapsulated within ethylcellulose-poly(ethylene oxide) (EC-PEO) nonwoven membranes, using a free-surface electrospinning technique. SEM showed that the morphol. of the fibers varied substantially with SP and HP ratio. Specific interactions between SP and HP with the polymers were not detected from the FTIR spectroscopy anal., suggesting that the precursors were mainly phys. entrapped within the EC-PEO fiber matrix. Headspace gas chromatog. showed that the release of hexanal and salicylaldehyde could be activated by contacting the precursor-containing electrospun nonwoven with an acidified agarose gel containing 0.003-0.3 M of citric acid. The delivery system can be promising for controlled release of hexanal and salicylaldehyde to extend the shelf-life of fruits and vegetables.

SN Applied Sciences published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C7H14N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia