Month: November 2022

Neugebauer, Franz A. published the artcileAminyls. 7. Diarylaminyls, SDS of cas: 1821-27-8, the publication is Chemische Berichte (1974), 107(7), 2362-82, database is CAplus.

The diarylaminyls I [Rn = e.g. 4-O2N, 4-NC, 4-EtO2C, 3,5-(Me3C)2, 3,5-Me2, or 2,4,6-Me3] and II (R1 = R2 = Me or R1R2 = O) were prepared by thermal or photolytic dissociation of the corresponding hydrazines or by H abstraction from the corresponding amines and studied by ESR, as were the corresponding N-oxides. The influence of the substitution on the properties of the diphenylaminyl system and on the dissociation of the tetraarylhydrazines was discussed.

Chemische Berichte published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, SDS of cas: 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cater, Henry L. published the artcileUser Guide to Ring-Opening Metathesis Polymerization of endo-Norbornene Monomers with Chelated Initiators, Computed Properties of 6950-53-4, the publication is Macromolecules (Washington, DC, United States) (2022), 55(15), 6671-6679, database is CAplus.

The development of facile synthetic strategies to access well-defined polymers promises to provide advanced soft materials with functionality that rivals that observed from nature. To this end, ring-opening metathesis polymerization (ROMP) presents a compositionally simple and rapid strategy for controlled polymerization, yet it has received far less attention relative to radical counterparts. This limited attention arises in part from scattered reports on optimization strategies and a narrow monomer scope. Contemporary ROMP methods favor the use of exo-norbornene derivatives and highly reactive nonchelated Ru-alkylidenes, such as Grubbs Catalysts. In contrast, endo-norbornene derivatives, from which analogous exo-forms are often generated, present a more accessible alternative, yet examples of their utility in ROMP remain scarce. Herein, a systematic examination of ROMP with endo-norbornene monomers using stable chelated Ru-alkylidene initiators is presented. Through initiator screening and polymerization optimization, the ROMP process is shown to be versatile and robust, providing rapid access to polymers with excellent mol. weight control, low dispersities (D < 1.1), good functional group tolerance, and high chain-end fidelity that enabled the preparation of block copolymers via sequential monomer addition Furthermore, the process is oxygen-tolerant, allowing for ROMP to be performed under ambient conditions on the bench, which was showcased in synthesizing mech. robust endo-norbornene imide thermoplastics with high glass transition and decomposition temperatures This report provides a comprehensive overview of the scope and limitations of endo-norbornene ROMP with chelated initiators, serving as a user guide for the polymer chem. community to develop well-defined next-generation functional plastics.

Macromolecules (Washington, DC, United States) published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C3H10ClNS, Computed Properties of 6950-53-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Starshinov, A. A. published the artcileThe first examples of synthesis of 1,3-diaza-5-azoniaadamantane-5-oxo-1,3,2,5-dioxaborataphosphorinanes, Recommanded Product: 1,3,5-Triazaadamantan-7-amine, the publication is Zhurnal Obshchei Khimii (1996), 66(7), 1125-1127, database is CAplus.

Borylation of PhP(O)(CHROH)₂ (R = H, C₆H₄Cl-4) with Ph₂BOiBu in the presence of appropriately-substituted triazaadamantanes in Me₂CO and/or MeCN gave 12-62% cyclic title compounds I (R = H, X = H, Cl, NH₂; R = C₆H₄Cl-4, X = NH₂).

Zhurnal Obshchei Khimii published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C9H12O, Recommanded Product: 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuznetsov, R. M. published the artcileSynthesis of aminomethylphosphines with triazaadamantane fragments, Product Details of C7H14N4, the publication is Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (2001), 71(6), 899-902, database is CAplus.

The reaction of (hydroxymethyl)diphenylphosphine with 7-amino-1,3,5-triazaadamantane, followed by ready oxidation of the initially formed aminomethylphosphine gave diphenyl[(1,3,5-triazaadamantan-7-yl)aminomethyl]phosphine oxide. The reactions of bis(hydroxymethyl)phenylphosphine with 2 mol of 7-amino-1,3,5-triazaadamantane in the absence and in the presence of Paraform provided bis[(1,3,5-triazaadamantan-7-yl)aminomethyl]phenylphosphine and 1,3-bis(1,3,5-triazaadamantan-7-yl)-5-phenyl-1,3,5-diazaphosphorinane, resp.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Product Details of C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karasu, Feyza published the artcilePhotoinitiated polymerization of β-cyclodextrin/methyl methacrylate host/guest complex in the presence of water soluble photoinitiator, thioxanthone-catechol-O,O’-diacetic acid, HPLC of Formula: 5411-14-3, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2010), 68(1-2), 147-153, database is CAplus.

β-Cyclodextrin (β-CD) was used to complex the monomer, Me methacrylate (MMA), yielding a water-soluble host/guest complex. Photoinitiated polymerization of β-CD/MMA complex was achieved in the presence of thioxanthone-catechol-O,O’-diacetic acid (TX-Ct), a one component water soluble photoinitiator. Photodecarboxylation of TX-Ct in water seems to be an important reaction mechanism. Therefore, resulting alkyl radicals are able to initiate the polymerization of β-CD/MMA host/guest complex in water.

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, HPLC of Formula: 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mercado, D. Fabio published the artcileSynthesis and use of functionalized SiO₂ nanoparticles for formulating heavy oil macroemulsions, Quality Control of 13822-56-5, the publication is Chemical Engineering Science (2022), 117531, database is CAplus.

There has been a growing interest in applying nanoparticles for enhanced oil recovery. Within this context, there is a need to understand the influence of the factors involved in the formulation of nanoparticle based emulsions over their properties. In this contribution, functionalized SiO₂ nanoparticles of two different sizes were synthesized and used as surfactants for the formulation of emulsions with two model oils: squalane and vacuum gas oil. Factorial experiments were made to analyze effects of particle size, water content, emulsification energy, and of the non-additive (second and third order interactions) effects between these variables over droplet size distributions, polydispersity, and over the rheol. profiles of the formulated emulsions. It was found that the functionalized SiO₂ nanoparticles produced either water in oil (W/O) or oil in water (O/W) macroemulsions depending on the chem. nature of the oil phase; namely, squalane made W/O emulsions and vacuum gas oil made O/W emulsions. Addnl., it was demonstrated that non-additive factors play an important role over the properties of the emulsions, especially for the vacuum gas oil based emulsions. Therefore, this work demonstrates that simpler linear relationships do not suffice for finding the best conditions for formulating crude oil type emulsions aimed for applications such as enhanced oil recovery.

Chemical Engineering Science published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Quality Control of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Junker, Anna published the artcileStructure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y₁₄ Receptor Antagonists, HPLC of Formula: 866683-57-0, the publication is Journal of Medicinal Chemistry (2016), 59(13), 6149-6168, database is CAplus and MEDLINE.

UDP and UDP-glucose activate the P2Y₁₄ receptor (P2Y₁₄R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y₁₄R antagonist (3, PPTN) using docking and mol. dynamics simulations on a hP2Y₁₄R homol. model based on P2Y₁₂R structures. By reevaluating the binding of 3 to P2Y₁₄R computationally, two alternatives, i.e., alkynyl and triazolyl derivatives, were identified. Improved synthesis of fluorescent antagonist 4 enabled affinity quantification (IC₅₀s, nM) using flow cytometry of P2Y₁₄R-expressing CHO cells. p-F₃C-phenyl-triazole 65 (32) was more potent than a corresponding alkyne 11. Thus, addnl. triazolyl derivatives were prepared, as guided by docking simulations, with nonpolar aryl substituents favored. Although triazoles were less potent than 3 (6), simpler synthesis facilitated further structural optimization. Addnl., relative P2Y₁₄R affinities agreed with predicted binding of alkynyl and triazole analogs. These triazoles, designed through a structure-based approach, can be assessed in disease models.

Journal of Medicinal Chemistry published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C9H5F3O, HPLC of Formula: 866683-57-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dhra, Gulshan published the artcilePolyelectrolyte proton exchange membranes: synthesis and characterization of sulfonated polyimide membranes using novel stilbene-containing diamine, Name: 4-Nitrophenylacetic acid, the publication is Polymer Bulletin (Heidelberg, Germany) (2022), 79(3), 1679-1697, database is CAplus.

A new unsym. diamine, 4-(2-aminophenoxy)-4′-aminostilbene was successfully synthesized and used to synthesize stilbene-containing sulfonated polyimides. 2,2′-Benzidine-disulfonic acid, 1,4,5,8-naphthalene tetracarboxylic dianhydride and different mole ratios of 4-(2-aminophenoxy)-4′-aminostilbene and 2-bis(4-(4-aminophenoxy)phenyl) hexafluoropropane were used for the synthesis of stilbene-containing polyimides with sulfonic acid groups. The synthesized polymers were characterized using various physicochem. characterization techniques such as NMR spectroscopy, IR spectroscopy, differential scanning calorimetry, thermogravimetric anal. and electrochem. impedance spectroscopy. Furthermore, the viscosity, water uptake, ion exchange capacity, swelling ratio, hydrolytic stability, oxidative stability, mech. properties and proton conductivity of the synthesized membranes were also analyzed. Sulfonated polyimide membranes showed a water uptake capacity of 18.93-28.89%, proton conductivity of 0.028-0.039 S cm^-1 at 30°C, ion exchange capacity of 1.469 meq g^-1 and hydrolytic stability of 40-44 h at 80°C. The solubility of the sulfonated polyimide membranes was improved when unsym. diamine was used to prepare sulfonated polyimides.

Polymer Bulletin (Heidelberg, Germany) published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Name: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kunchur, Harish S. published the artcilePlatinum Assisted Tandem P-C Bond Cleavage and P-N Bond Formation in Amide Functionalized Bisphosphine o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o: Synthesis, Mechanistic, and Catalytic Studies, Category: catalysis-chemistry, the publication is Inorganic Chemistry (2022), 61(2), 857-868, database is CAplus and MEDLINE.

The reactions of amide functionalized bisphosphine o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o (1) with Pt salts is described. Treatment of 1 with [Pt(COD)Cl₂] yielded a chelate complex, [PtCl₂{o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o}κ²-P,P] (2), which on subsequent treatment with LiHMDS formed a novel 1,2-azaphospholene-phosphine complex [PtPhCl{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (3) involving a tandem P–C bond cleavage and P-N bond formation. The same complex 3 on passing dry HCl gas afforded dichloro-complex [PtCl₂{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (5). Complex 2 upon refluxing in toluene or treatment of 1 with [Pt(COD)Cl₂] in the presence of a base at room temperature resulted in pincer complex [PtCl{o-Ph₂PC₆H₄C(O)N(C₆H₄PPh₂-o)}κ³-P,N,P] (4). Reaction of 1 with [Pt(COD)ClMe] at room temperature also afforded the pincer complex [PtMe{o-Ph₂PC₆H₄C(O)N(C₆H₄PPh₂-o)}κ³-P,N,P] (6). Mechanistic studies on 1,2-azaphospholene formation showed the reductive elimination of LiCl to form a phosphonium salt that readily adds one of the P-C bonds oxidatively to the in situ generated Pt⁰ species to form a chelate complex 3. Analogous Pd complex [PdCl₂{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (7) showed excellent catalytic activity toward N-alkylation of amines with alcs. with a very low catalyst loading (0.05 mol %), and the methodol. is very efficient toward the gram scale synthesis of many N-alkylated amines.

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tamura, Ryo published the artcilePhotoactivatable Prodrug of Doxazolidine Targeting Exosomes, Quality Control of 1395786-30-7, the publication is Journal of Medicinal Chemistry (2019), 62(4), 1959-1970, database is CAplus and MEDLINE.

Natural lipid nanocarriers, exosomes, carry cell-signaling materials such as DNA and RNA for intercellular communications. Exosomes derived from cancer cells contribute to the progression and metastasis of cancer cells by transferring oncogenic signaling mols. to neighboring and remote premetastatic sites. Therefore, applying the unique properties of exosomes for cancer therapy has been expected in science, medicine, and drug discovery fields. Herein, we report that an exosome-targeting prodrug system, designated MARCKS-ED-photodoxaz, could spatiotemporally control the activation of an exquisitely cytotoxic agent, doxazolidine (doxaz), with UV light. The MARCKS-ED peptide enters a cell by forming a complex with the exosomes in situ at its plasma membrane and in the media. MARCKS-ED-photodoxaz releases doxaz under near-UV irradiation to inhibit cell growth with low nanomolar IC₅₀ values. The MARCKS-ED-photodoxaz system targeting exosomes and utilizing photochem. will potentially provide a new approach for the treatment of cancer, especially for highly progressive and invasive metastatic cancers.

Journal of Medicinal Chemistry published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C8H6F3NO, Quality Control of 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia