Month: December 2022

Siddiqui, Aness Ahmad published the artcileSynthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues, Related Products of catalysis-chemistry, the publication is Bioorganic Chemistry (2020), 103584, database is CAplus and MEDLINE.

A series of hybrid pyridazinone-thiazoles (I)[R = Ph, p-tolyl, p-anisyl, etc.] connected through amide linkage were designed and synthesized. Among these, compound I [R = p-chlorophenyl] demonstrated significant anticonvulsant activity with median ED of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Mol. docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of I [R = p-chlorophenyl].

Bioorganic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C31H25F2N5O7S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ahmed, Syed T. published the artcileEngineered Ammonia Lyases for the Production of Challenging Electron-Rich L-Phenylalanines, Formula: C11H12O4, the publication is ACS Catalysis (2018), 8(4), 3129-3132, database is CAplus.

Engineered variants of phenylalanine ammonia lyase from Planctomyces brasiliensis were developed through rational design efforts focusing on the aryl binding pocket of the active site, guided by structural and phylogenetic inference. Inherent problems traditionally associated with the biocatalytic hydroamination of acrylic acids, such as low conversion and poor regioselectivity with alkyl and methoxy derivatives, could be overcome. The PbPAL variants described here represent a valuable addition to the biocatalytic toolbox, allowing previously inaccessible amino acid building blocks to be obtained regio- and enantioselectively on preparative scale.

ACS Catalysis published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mooney, Ciaran R. S. published the artcileCrystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO₂ [Erratum to document cited in CA162:197128], Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Angewandte Chemie, International Edition (2015), 54(26), 7470, database is CAplus and MEDLINE.

The authors believe that that a single crystal of [(n-C₄H₉)₄N]⁺[CH₃CO₂]^– impurity was misidentified as [(n-C₄H₉)₄N]⁺[O₂C¡¤¡¤¡¤OH]^–; a discussion is provided.

Angewandte Chemie, International Edition published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hong, Seung Youn published the artcileSelective formation of ¦Ã-lactams via C-H amidation enabled by tailored iridium catalysts, Name: 2-Methyl-4-phenylbutanoic acid, the publication is Science (Washington, DC, United States) (2018), 359(6379), 1016-1021, database is CAplus and MEDLINE.

Intramol. insertion of metal nitrenes into C-H bonds to form ¦Ã-lactam rings has traditionally been hindered by competing isocyanate formation. The application of theory and mechanism studies to optimize a class of Ir(III) pentamethylcyclopentadienyl catalysts for suppression of this competing pathway is reported. Modulation of the stereoelectronic properties of the auxiliary bidentate ligands to be more electron-donating was suggested by d. functional theory calculations to lower the C-H insertion barrier favoring the desired reaction. These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding ¦Ã-lactams via sp³ and sp² C-H amidation with exceptional selectivity. The power of this method was further demonstrated by the late-stage functionalization of amino acid derivatives and other bioactive mols.

Science (Washington, DC, United States) published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Name: 2-Methyl-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Seok published the artcileElectrochemical behaviors of polymer composite electrolytes containing functionalized nanosize clays, Quality Control of 28056-87-3, the publication is Journal of Nanoscience and Nanotechnology (2010), 10(1), 325-328, database is CAplus and MEDLINE.

Functionalized nanosize clay effect on the poly(ethylene oxide) (PEO)-based polymer composite electrolytes (PCE) were prepared and studied. To understand the effects of organic-functionalized montmorillonite (OMMT) on the ionic conductivity, microstructure and electrochem. property were studied. XRD results revealed that the PCE containing MMT-20A showed interlayer spacing length, 2.55 nm, while the PCE containing Na-MMT showed the value, 1.16 nm. By changing the OMMT species, the interlayer spacings were controlled. The XRD and thermal anal. results indicated that the PCE showed the reduced crystallinity by introduction of OMMT fillers. PCE containing MMT-20A showed the triple higher conductivity, 6.1 ^* 10^-4 S/cm, than PCE containing Na-MMT. The improved ion conductivity was dependent on the reduced crystallinity that was correlated with the d-spacing of MMT.

Journal of Nanoscience and Nanotechnology published new progress about 28056-87-3. 28056-87-3 belongs to catalysis-chemistry, auxiliary class Amine,Aliphatic hydrocarbon chain, name is 2-Ethyl-N,N-dimethylhexan-1-amine, and the molecular formula is C10H23N, Quality Control of 28056-87-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yun Soo Choi published the artcileStereoselective substitution of configurationally labile ¦Á-bromo aryl-acetates with amines and azlactones by L-threonine-mediated crystallization-induced dynamic resolution, SDS of cas: 140-28-3, the publication is European Journal of Organic Chemistry (2016), 2016(14), 2539-2546, database is CAplus.

We developed a highly stereoselective C-N and C-C bond-forming reaction by carrying out a crystallization-induced dynamic resolution (CIDR) of ¦Á-bromo arylacetates followed by a stereoselective substitution reaction with an amine or azlactone nucleophile. Applications of this synthetic method to the preparation of highly enantioenriched nitrogen-containing six-membered heterocycles and ¦Á,¦Â-disubstituted aspartates are also presented.

European Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C4H11NO, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moon, Byung Seok published the artcileHighly efficient production of [¹⁸F]fallypride using small amounts of base concentration, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Applied Radiation and Isotopes (2010), 68(12), 2279-2284, database is CAplus and MEDLINE.

To minimize the base concentration of a phase-transfer catalyst, [¹⁸F]fluoride was extracted from ¹⁸O-enriched water trapped on an activated ion exchange cartridge (Chromafix PS-HCO₃) using different concentrations of tetrabutylammonium bicarbonate (TBAHCO₃) or Kryptofix 2.2.2./K₂CO₃ in organic solvents such as CH₃CN/H₂O or MeOH/H₂O. The optimal labeling condition for [¹⁸F]fallypride with automated synthesis was that 2 mg of tosyl-fallypride in acetonitrile (1 mL) was heated at 100 ¡ãC for 10 min using 40% TBAHCO₃ (10 ¦ÌL). [¹⁸F]Fallypride was obtained with a high radiochem. yield of approx. 68¡À1.6% (decay-corrected, n=42) with a total synthesis time of 51¡À1.2 min, including HPLC purification and solid-phase purification for the final formulation.

Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yoon, Ki-Yong published the artcileUnveiling role of Ti dopant and viable Si doping of hematite for practically efficient solar water splitting, Product Details of C6H17NO3Si, the publication is ACS Catalysis (2022), 12(9), 5112-5122, database is CAplus.

Doping engineering is of key importance for controlling the elec., optical, and structural properties of a semiconductor. In more expanded doping systems, codoping with deep insight and understanding of interactions between impurities is necessary to make an efficient photoelectrode. Here, we show that the high formation energy of a Si-doped hematite can be decreased with the introduction of a host Ti-dopant, making easy and cost-efficient solution-based Si doping possible. The effect of the pos. interaction between dopants lowers the formation energy in a standard atm. to the one under extreme conditions of about 10^-10 atm. By taking advantage of formation energy control, we achieved a photocurrent d. of 4.3 mA cm^-2 at 1.23 V_RHE in the optimized Si:Ti codoped hematite with a cocatalyst without using any demanding exptl. processes. Our study suggests a ground rule for the facile incorporation of the high-formation-energy dopant into photocatalysts, which can be readily extended to other doped systems to achieve a substantial improvement in PEC performance.

ACS Catalysis published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is CBF6K, Product Details of C6H17NO3Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Webb, Eric W. published the artcileNucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of the American Chemical Society (2020), 142(20), 9493-9500, database is CAplus and MEDLINE.

A redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters e.g., I using an Ir photocatalyst under visible light irradiation was reported. The method provides access to a broad range of aliphatic fluorides, including primary, secondary, and tertiary benzylic fluorides as well as unactivated tertiary fluorides, that are typically inaccessible by nucleophilic fluorination due to competing elimination. In addition, the decarboxylative fluorination conditions are readily adapted to radiofluorination with [18F]KF. The reactions proceed by two electron transfers between the Ir catalyst and redox-active ester substrate to afford a carbocation intermediate that undergoes subsequent trapping by fluoride. Examples of trapping with O- and C-centered nucleophiles and deoxyfluorination via N-hydroxyphthalimidoyl oxalates are also presented, suggesting that this approach may offer a general blueprint for affecting redox-neutral SN1 substitutions under mild conditions.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C20H21ClN4O4, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pearson, Anthony J. published the artcileModel studies on the synthesis of carboxylate-binding pocket analogs of vancomycin using arene-ruthenium chemistry, Safety of 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Journal of Organic Chemistry (1992), 57(6), 1744-52, database is CAplus.

Preparation of several protected L–p-chlorophylalanine derivatives in high optical purity and their complex formation with [CpRu(MeCN)₃]PF₆ (Cp = cyclopentadienyl) are described. The complexation reaction, as well as subsequent photochem. decomplexations, proceeds with retention of optical purity. Reactions of these chloroarene complexes with 3-hydroxyphenylglycine derivatives proceed mild conditions to give aryl ether-ruthenium complexes, which can be converted to diaryl ethers in which both aromatic rings have protected amino acid or peptide side chains. Efforts to effect cycloamidation to give vancomycin carboxylate-binding pocket analogs using a number of known coupling reagents were unsuccessful.

Journal of Organic Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Safety of 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia