Month: December 2022

Boger, Dale L. published the artcileHigher order iminodiacetic acid libraries for probing protein-protein interactions, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Bioorganic & Medicinal Chemistry (1998), 6(8), 1347-1378, database is CAplus and MEDLINE.

Full details of the preparation of iminodiacetic acid diamide dimer (2040 compounds), trimer (560 compounds), and tetramer (1596 compounds) libraries by multistep convergent solution-phase synthesis for studying protein-protein interactions are provided. The libraries were assembled in a format providing small 8-10 compound mixtures and the deconvolution of many of the small mixtures to identify screening leads by resynthesis of the individual components were conducted for 320 of the individual compounds to date. A representative example of the subsequent exploration of the structure-activity relationships for an identified receptor binding antagonist (200 addnl. individual compounds) and steps taken for potential elaboration to a receptor dimerization agonist are defined with preparation of representative linked dimers (70 compounds).

Bioorganic & Medicinal Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Burger, Klaus published the artcileHexafluoroacetone as protective group and activating reagent in amino acid and peptide chemistry. 10. Synthesis of 3-(thiazol-4-yl)alanine and 3-(selenazol-4-yl)alanine derivatives from aspartic acid, Computed Properties of 6972-05-0, the publication is Synthesis (1992), 1145-50, database is CAplus.

3-(Thiazol-4-yl)alanines I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 2-furyl, NMe₂, 4-FC₆H₄, 2-thienyl, H, Me; R¹ = H, Me) and the 3-(selenazol-4-yl)alanine II were obtained from aspartic acid via 2,2-bis(trifluoromethyl)-4-(3-bromo-2-oxopropyl)-1,3-oxazolidin-5-one in a Hantzsch synthesis, using hexafluoroacetone as protective group.

Synthesis published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sarkissian, Elin published the artcileStrategy for Selective C_sp2-F and C_sp2-C_sp2 Formations from Organoplatinum Complexes, COA of Formula: C14H14, the publication is Inorganic Chemistry (2021), 60(2), 1016-1020, database is CAplus and MEDLINE.

By changing the parameters of fluorination reaction of bisaryl-platinum(II) complexes, each possible competitive pathway of Ar-Ar and Ar-F formation can be selectively controlled. It was discovered that steric hindrance, type of fluorinating reagent, and temperature of reaction are determinants for Ar-F vs Ar-Ar bond formation pathway from bisaryl-fluoro-platinum(IV) complexes. The combination of bulky ligands such as mesityl with Selectfluor at RT leads to Ar-F bond formation in the presence of possible Ar-Ar formation. Selective Ar-F and Ar-Ar bond formation from organoplatinum complexes by controlling fluorinating reagents, steric hindrance and temperature

Inorganic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, COA of Formula: C14H14.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhatt, Vasishta D. published the artcileIon exchange synthesis and thermal characteristics of some [N⁺₄₄₄₄] based ionic liquids, Related Products of catalysis-chemistry, the publication is Thermochimica Acta (2013), 23-29, database is CAplus.

Eight salts, derived from tetrabutylammonium cation [N⁺₄₄₄₄] and inorganic anions like BF₄^–, NO₃^–, NO₂^–, SCN^–, BrO₃^–, IO₃^–, PF₆^– and HCO₃^– were synthesized using the ion exchange method. These ionic liquids (ILs) were characterized using thermogravimetry, differential scanning calorimetry and IR spectroscopy. Thermophys. properties such as d., volume expansion, heat of fusion, heat of solid-solid transitions, sp. heat capacity and thermal energy storage capacity were determined The total of heat of solid-solid transitions observed below the m.ps. exceeded the heat of fusion in some cases. The thermal conductivity of the samples was determined both in solid and liquid phases. High values of thermal energy storage capacity and handsome liquid phase thermal conductivities made many of the ionic liquids under investigation were recommended as Thermal Energy Storage Devices (TESDs) as well as heat transfer fluids.

Thermochimica Acta published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bhatt, Vasishta D. published the artcileIon exchange synthesis and thermal characteristics of some [N⁺₂₂₂]-based ionic liquids, Application In Synthesis of 17351-61-0, the publication is Bulletin of Materials Science (2013), 36(6), 1121-1125, database is CAplus.

Eight salts were obtained by reacting tetraethylammonium cation [N⁺₂₂₂] with inorganic anions like BF₄^–, NO₃^–, NO₂^–, SCN^–, BrO₃^–, IO₃^–, PF₆^–, and HCO₃^– using ion exchange method. These ionic liquids (ILs) were characterized using thermal methods, IR spectroscopy, and densitometry. Thermophys. properties such as d., coefficient of volume expansion, heat of fusion, heat capacity, and thermal energy storage capacity were determined Thermal conductivity of the samples was determined both in solid and liquid phases. Owing to high values of thermal energy storage capacity coupled with handsome liquid phase thermal conductivity, ILs under investigation were recommended as materials for thermal energy storage (TES) as well as heat transfer applications.

Bulletin of Materials Science published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Application In Synthesis of 17351-61-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Lijuan published the artcileBrown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE), HPLC of Formula: 63-68-3, the publication is Scientific Reports (2022), 12(1), 3693, database is CAplus and MEDLINE.

Both hyperthyroidism and elevated plasma branched chain amino acids (BCAA) are associated with insulin resistance. BCAA utilization and clearance relative to thyroid status changes remains unclear. We investigate amino acids changes, specifically BCAA, during the transition from hyperthyroidism to euthyroidism, and the impact of active brown adipose tissue (BAT) on the metabolic effects of BCAA. Newly diagnosed Graves disease participants were recruited. Hyperthyroidism was treated via a titration dosing regimen of thionamide anti-thyroid drug to establish euthyroidism over 12-24 wk. All underwent energy expenditure (EE) measurement within a chamber calorimeter, 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomog./magnetic resonance (PET/MR) imaging and plasma amino acids measurement during hyperthyroidism and euthyroidism. PET BAT maximum standardized uptake value (SUVmax), SUVmean and MR supraclavicular fat fraction (FF) quantified BAT activity. Twenty-two patients completed the study. Plasma BCAA level was significantly reduced in BAT-pos. but not in BAT-neg. patients during the transition from hyperthyroidism to euthyroidism. Plasma valine but not leucine and isoleucine correlated pos. with insulin and HOMA-IR in hyperthyroidism. Plasma valine, leucine and isoleucine correlated with insulin and HOMA-IR in euthyroidism. Plasma valine correlated with insulin and HOMA-IR in BAT-neg. but not in BAT-pos. participants in both hyperthyroid and euthyroid state. However, the change (i.e. decrease) in plasma valine concentration from hyperthyroid to euthyroid state was affected by BAT-status. BAT utilizes and promotes BCAA plasma clearance from hyperthyroid to euthyroid state. Active BAT can potentially reduce circulating BCAA and may help to ameliorate insulin resistance and improve metabolic health. Clin. trial registration: The trial was registered at clinicaltrials.gov as NCT03064542.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C10H16Br3N, HPLC of Formula: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Santra, Soumava published the artcileStructural Exploration of (3S,6S)-6-Benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants, Computed Properties of 457-68-1, the publication is ChemMedChem (2012), 7(12), 2093-2100, database is CAplus and MEDLINE.

To further explore the basic structural motifs (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine and (2S,4R,5R)-2-benzhydryl-5-(benzylamino)tetrahydro-2H-pyran-4-ol, developed by our research group, for monoamine transport inhibition, we designed and synthesized various structurally altered analogs. The new compounds were tested for their affinities for the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET) in rat brain by measuring their capacity to inhibit the uptake of [³H]DA, [³H]5-HT, and [³H]NE, resp. Our results point to novel compounds with a TUI, DNRI, SNRI, or SSRI profile. Among the TUIs, compound 2 g exhibited a balanced potency for all three monoamine transporters (K_i: 60, 79, and 70.3 nM for DAT, SERT, and NET, resp.). In the rat forced swim test, compound 2 g produced a significant decrease in immobility in drug-treated rats relative to vehicle, indicating a potential antidepressant property.

ChemMedChem published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Computed Properties of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vasireddy, Purna C. R. published the artcilePalladium-catalyzed aryl group transfer from triarylphosphines to arylboronic acids, Category: catalysis-chemistry, the publication is Polyhedron (2022), 115550, database is CAplus.

A study of Pd-catalyzed arylation of arylboronic acids with triarylphosphines is presented. Various parameters of this transformation, such as the oxygen presence, choice of solvent, temperature, palladium source, bases and oxidants, were tested and the optimal conditions of the aryl transfer were determined The effect of electron-withdrawing and electron-donating substituents on the aryl groups of both reactants was also investigated. The unusual transfer of the acetate group from Pd(OAc)₂ to p-nitrophenylboronic acid in the presence of triarylphosphines is reported. A plausible mechanism of the Pd-catalyzed aryl group transfer from triarylphosphines to the arylboronic acid is proposed.

Polyhedron published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C7H5Br2F, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Syamal, A. published the artcileSyntheses of trimethylenedibiguanide sulfate and copper(II), nickel(II), palladium(II), and zinc(II) complexes of trimethylenedibiguanide, Formula: C3H12Cl2N2, the publication is Journal of Inorganic and Nuclear Chemistry (1978), 40(8), 1606-9, database is CAplus.

[M(H₂L)]Cl₂ (M = Cu, Ni, Pd; H₂L = trimethylenedibiguanide) and ZnL were prepared and characterized by elemental anal., magnetic, electronic, and IR spectral data. The dibiguanide acts as a quadridentate, neutral ligand in [M(H₂L)]Cl₂, and as a quadridentate dibasic ligand in ZnL. The ligand was prepared as H₂L.2H₂SO₄ by fusing [H₂N(CH₂)₃NH₂].2HCl, dicyandiamide, and CuSO₄.5H₂O at 140-145¡ã, and finally removing Cu as CuS.

Journal of Inorganic and Nuclear Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C14H31NO2, Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia