Month: December 2022

Vitali, Alberto published the artcile¦Â-glucosyltransferase in cell cultures of Verbesina caracasana, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Heterocycles (1999), 50(2), 721-730, database is CAplus.

(E)-3,4-Dimethoxycinnamic acid, inoculated in cell cultures of Verbesina caracasana, was converted to the corresponding ¦Â-glucopyranoside ester, revealing the presence of an exoglucosyltransferase. An extensive study on other cinnamic acid derivatives showed that the aromatic ring must contain at least one methoxy substituent, but no hydroxy group, for the esterification to be performed. Moreover, the presence of the double bond was shown to have no influence. The glucosylation reaction may involve also the hydroxyl of benzyl alcs., with the same specificity towards the substitution of the aromatic ring as shown by the cinnamic acids.

Heterocycles published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C23H20BN, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chakravarti, Duhkhaharan published the artcileSynthesis of coumarins from ¦Ï-hydroxyaryl alkyl ketones. IV. Formation of ¦Ï-coumaric acids from ¦Ï-hydroxy aldehydes, Computed Properties of 16909-09-4, the publication is Journal of the Indian Chemical Society (1943), 338-40, database is CAplus.

cf. C. A. 34, 6252.7. Reformatski¨« reactions of some 2-methoxybenzaldehydes gave HO esters which on dehydration and hydrolysis yielded trans-¦Ï-coumaric acids. It was shown that 2-MeO aldehydes, always lead to trans-¦Ï-methoxycinnamic acids by Perkin’s reaction, by malonic acid condensation, and by the method of Chakravarti and Majumdar (Reformatski¨«) (cf. C. A. 34, 2348.9). A mixture of 8 g. 5,2-Me(MeO)C₆H₃CHO (I), 13.4 g. BrCH₂CO₂Et (II), 5.5 g. Zn wool and 75 cc. anhydrous benzene was heated at 100¡ã for 2.5 h. and poured into ice-cold dilute H₂SO₄. After washing and drying, the benzene layer was distilled, yielding 5.5 g. of Et ¦Â-hydroxy-¦Â-(2-methoxy-5-methylphenyl)propionate, b₁₂ 200¡ã, which was converted by treating with 3 g. SOCl₂ and 3 g. pyridine in 100 cc. anhydrous Et₂O into 3.8 g. Et 2-methoxy-5-methyl-trans-cinnamate (III), b₇ 165¡ã. Hydrolysis of III with alc. KOH gave the free trans acid (IV), m. 145-6¡ã, which was identical with the compound obtained in good yield by heating 1 g. I with 2 g. Ac₂O and 8 g. fused AcONa at 180¡ã for 10 h., extracting with alkali and acidifying with HCl. Similarly I was converted by Reformatski¨«’s reaction with Zn and MeCHBrCO₂Et (V) to the corresponding HO ester which was dehydrated with SOCl₂ and pyridine to Et ¦Á-methyl-2-methoxy-5-methylcinnamate (VI), b₅ 160¡ã. Alc. KOH hydrolysis of VI gave the trans acid, m. 109-10¡ã, identical with the acid obtained by heating I with EtCO₂Na and (EtCO)₂O. By the same series of reactions the following compounds were prepared: Et 2,4-dimethoxycinnamate, brown viscous liquid, b₆ 160¡ã (trans acid (VII), m. 184¡ã); Et ¦Á-methyl-2,4-dimethoxycinnamate, viscous brown liquid, b₆ 200¡ã (trans acid (VIII), m. 130¡ã); Et ¦Â-(2-methoxy-1-naphthyl)acrylate, b₄ 210-2¡ã; (free acid (IX), m. 153-4¡ã); Et ¦Á-methyl-¦Â-(2-methoxy-1-naphthyl)acrylate, viscous brown liquid, b₅, 220-5¡ã (free acid (X), m. 138-9¡ã). VII, VIII, IX, and X were also prepared by Perkin’s reaction and were compared with those compounds prepared above by mixed m. ps. In addition, condensation of 2,4-(MeO)₂C₆H₃CHO with malonic acid in the presence of piperidine also yielded the trans acid (VII). III or IV, heated with HI (d. 1.7) at 140¡ã for 2 h., yielded only a sticky precipitate which could not be crystallized No ring closure was effected.

Journal of the Indian Chemical Society published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Computed Properties of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cabani, S. published the artcileVolume changes in the proton ionization of amines in water. 2. Amino alcohols, amino ethers, and diamines, COA of Formula: C3H12Cl2N2, the publication is Journal of Physical Chemistry (1977), 81(10), 987-93, database is CAplus.

From d. measurements (25¡ã) of aqueous solutions at various concentrations of solute, apparent molar volumes of some open-chain bifunctional primary, secondary and tertiary amines were determined; the compounds studied were X(CH2)nNH2 (X = HO, MeO, H2N; n = 2,3) and 2-XCH2CH2OH (X = MeNH, EtNH, Me2N, Et2N) and their mono- and dihydrochlorides, for which ¦¤V1¡ã and ¦¤V2¡ã for the 1st and 2nd steps of proton ionization were calculated from the limiting partial molar volumes Values ¦¤V1¡ã for the above bifunctional amines are compared with the corresponding values for monofunctional amines, and the difference in ¦¤V1¡ã caused by the introduction of the 2nd hydrophilic center is discussed. The volumes and entropies of ionization of the amines and carboxylic acids are compared, and the deviations of these functions from predictions based on simple electrostatic theories are considered.

Journal of Physical Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, COA of Formula: C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wieland, Theodor published the artcileAntagonists of the Lactobacillus bulgaricus factor and of pantothenic acid, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride, the publication is Chemische Berichte (1952), 1035-42, database is CAplus.

According to the present concept of the mechanism of the action of pantothenic acid (I) in the living cell, I is incorporated into the coenzyme A (II) and is present there as the thioethanolamide (III), the SH group of which acts as acyl transcarrier in biol. acylation of amines and alcs. Certain lactic acid bacteria, e.g., Lactobacillus helveticus V 80 (IV), show a faster growth with a scission product of II, the so-called Lactobacillus bulgaricus factor (LBF), than with I, especially at the beginning. From this it may be concluded that during the II synthesis in these micro?rganisms I is converted into pantetheine (V) which is then, as a whole, built into II. To test this theory, derivatives of III are synthesized, differing only slightly from III but in such a way that the synthesis of II can be stopped by the competition with V. Adding CH₂.CH₂.NH to MeSH in 20 cc. EtOH at -15¡ã and keeping the mixture overnight at 20¡ã give MeSCH₂CH₂-NH₂ (VI), b₇₆₀ 146-8¡ã (HCl salt m. 120¡ã); EtSCH₂CH₂NH₂ b₇₆₀ 163¡ã (HCl salt m. 147¡ã). Keeping 1.2 g. absolute dry Na D-pantothenate (VII) in 5 cc. anhydrous HCONMe₂ and 0.5 g. ClCO₂Et several hrs. at 0¡ã, adding 0.46 g. VI, keeping the mixture several hrs., evaporating the filtered solution in vacuo, and purifying the residue in BuOH by the countercurrent extraction (CCE) method give 40% S-methylpantetheine (VIII), very viscous pale yellow oil; S-Et homolog (IX) and S-Ph analog (X) have similar properties. Adding 1.5 cc. liquid NH₃ at -60¡ã to the filtered reaction mixture of 2.4 g. VII, 1 g. ClCO₂Et, and 15 cc. HCONMe₂, evaporating the NH₃ and the solvent, finally at 40¡ã in vacuo, and purifying the residue by CCE in BuOH and H₂O give 40% D-pantothenamide (XI), oil, very soluble in H₂O and BuOH, slightly soluble in C₆H₆ and ether. Saturating 5 g. HOCH₂CMe₂CH(OH)CN in 50 cc. ether with dry HCl and keeping the mixture overnight give almost 100% [O.CH₂.CMe₂.CH(OH).C:NH₂]⁺Cl^– which failed to give XI on treatment with CH₂:CHCONH₂. At low concentrations VIII-X possess little growth activity with IV which, at higher concentrations, is annulled by LBF, V, and I. Whereas with VIII and IX this stoppage is overcome after a few days, with X it is stable because of a true competitive process whereby 30-70 mols. inhibitor per 1 mol. growth-promoting substance (XII) stops the growth by 50%. XI possesses no inhibitory action and can, at a higher concentration, completely substitute for XII. The results of the microbiol. tests are given in several curves.

Chemische Berichte published new progress about 6950-53-4. 6950-53-4 belongs to catalysis-chemistry, auxiliary class Salt,sulfides,Amine,Aliphatic hydrocarbon chain, name is 2-(Methylthio)ethanamine hydrochloride, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: 2-(Methylthio)ethanamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shcheglova, M. K. published the artcileScreening of bacteria degrading surface-active substances, Quality Control of 2016-56-0, the publication is Antibiotiki i Khimioterapiya (1989), 34(3), 192-4, database is CAplus and MEDLINE.

A procedure for detection of bacteria degrading cationic surface-active substances (CSAS) was developed. The procedure is based on the color of pyrocatechin violet, an organic dye, changing from green-blue in the presence of CSAS to red-brown in its absence. After application of pyrocatechin violet to bacterial macrocolonies grown on a synthetic medium with a CSAS as the only source of C, red-brown zones develope around the colonies, which is indicative of CSAS degradation A total of 55 strains of bacteria degrading undecylpyridinium bromide were isolated from water and sewage purification plants. Six bacterial strains degraded all 9 surfactants tested. Degradability was related to the presence of a long C chain, with branching, and a substituent in the aromatic ring. The procedure may be used for the rapid determination of degradation of CSASs with different chem. structures.

Antibiotiki i Khimioterapiya published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C10H20O2, Quality Control of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shapiro, B. L. published the artcileNMR spectral data: a compilation of aromatic proton chemical shifts in mono- and di-substituted benzenes, Computed Properties of 312-40-3, the publication is Journal of Physical and Chemical Reference Data (1977), 6(3), 919-91, database is CAplus.

NMR chem. shifts for protons directly attached to mono- and disubstituted benzenes are compiled from the literature. Data for 1053 sets of data are presented. The data were examined for reliability by using criteria which include high spectral quality, rigorous exptl. technique, and sufficient description to assure correct interpretation of results. The data, presented in tabular form, include compound name and formula, solvent employed, concentration, temperature, chem. shift, and observation frequency. Other NMR-related data are not given. An author index is included. The data and references cover the literature to June 1976.

Journal of Physical and Chemical Reference Data published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C13H17BClFO2, Computed Properties of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mirza-Aghayan, Maryam published the artcileSynthesis and characterization of palladium nanoparticles immobilized on graphene oxide functionalized with triethylenetetramine or 2,6-diaminopyridine and application for the Suzuki cross-coupling reaction, Name: 4,4′-Dimethyldiphenyl, the publication is Journal of Organometallic Chemistry (2022), 122160, database is CAplus.

Graphene oxide (GO) was functionalized with two organic ligands, triethylenetetramine (TETA) or 2,6-diaminopyridine (DAP), followed by palladium nanoparticles (Pd NPs) for the synthesis of Pd NPs/GO-TETA and Pd NPs/GO-DAP nanocomposites, resp. The two heterogeneous nanocomposites were fully characterized and their efficiency was investigated for C-C bond formation for the synthesis of biaryl compounds via the Suzuki cross-coupling reaction of aryl halides with arylboronic acid derivatives The obtained results indicated that the Pd NPs/GO-TETA nanocomposite was more effective in the Suzuki coupling reaction as compared to Pd NPs/GO-DAP. Thus, the Suzuki cross-coupling reaction of different aryl halides with arylboronic acid derivatives using Pd NPs/GO-TETA nanocomposite catalyst in the presence of Na₂CO₃ as base in DMF/H₂O (1/1) as solvent at 90¡ãC was carried out to afford the desired biaryl compounds in high to excellent yields (81-100%) and short reaction times (10-90 min). Addnl., Pd NPs/GO-TETA nanocomposite can be recovered and reused for 8 consecutive runs without any apparent loss of its catalytic activity, proving its high stability and potential use in organic transformations.

Journal of Organometallic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Name: 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Adib, Mehdi published the artcileA novel synthesis of 3-aryl-2,6-dicyano-5-methylanilines via reaction between nitrostyrenes and malononitrile, COA of Formula: C10H11NO4, the publication is Synthesis (2010), 1526-1530, database is CAplus.

A novel and simple synthesis of 3-aryl-2,6-dicyano-5-methylanilines is described. Reactions between nitrostyrenes and excess malononitrile in the presence of sodium carbonate in 80% ethanol proceeded at room temperature to afford the aromatic products in good yields. A mechanism for the formation of the products is proposed.

Synthesis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, COA of Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kandile, Nadia G. published the artcileQuinoline anhydride derivatives cross-linked chitosan hydrogels for potential use in biomedical and metal ions adsorption, HPLC of Formula: 2051-95-8, the publication is Polymer Bulletin (Heidelberg, Germany) (2022), 79(4), 2461-2486, database is CAplus.

Chem. modification of chitosan is one of the methods to increase the reactivity of chitosan toward many applications. The presence of primary amino groups in chitosan permits its modifications with different agents. New three-dimensional network structure hydrogels (Va-f) and (Va-f)G were prepared via reaction of chitosan with 3-(carboxymethyl)-2-aryl-6-alkylquinoline-4-carboxylic acid anhydride derivatives (IVa-f) in the absence and/or presence of glutaraldehyde as crosslinking agent, resp. The hydrogels were characterized using FTIR spectroscopy, X-ray diffraction, solubility, swelling behavior, thermal anal., surface morphol. and biodegradability. Evaluation of the hydrogels toward antibacterial activity, load and release of lidocaine and efficiency of metal ions uptake (Co+2 and Hg+2) was investigated. Hydrogel (Ve) revealed the highest activities toward (Gram -Ve) E. coli and Proteus and (Gram +Ve) S. aureus and B. subtilis bacteria than chitosan. However, hydrogel (Ve)G revealed the highest drug loading and release and showed also the potent efficiency toward metal ions uptake for Co+2 and Hg+2.

Polymer Bulletin (Heidelberg, Germany) published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, HPLC of Formula: 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Medvedev, Alexander published the artcileComprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay, Computed Properties of 6217-54-5, the publication is Scientific Reports (2022), 12(1), 3115, database is CAplus and MEDLINE.

Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homol., NR ligands often interact with multiple receptors. Here, we describe a multiplex reporter assay (the FACTORIAL NR) that enables parallel assessment of NR ligand activity across all 48 human NRs. The assay comprises one-hybrid GAL4-NR reporter modules transiently transfected into test cells. To evaluate the reporter activity, we assessed their RNA transcripts. We used a homogeneous RNA detection approach that afforded equal detection efficacy and permitted the multiplex detection in a single-well format. For validation, we examined a panel of selective NR ligands and polypharmacol. agonists and antagonists of the progestin, estrogen, PPAR, ERR, and ROR receptors. The assay produced highly reproducible NR activity profiles (r > 0.96) permitting quant. assessment of individual NR responses. The inferred EC50 values agreed with the published data. The assay showed excellent quality (<Z> = 0.73) and low variability (<CV> = 7.2%). Furthermore, the assay permitted distinguishing direct and non-direct NR responses to ligands. Therefore, the FACTORIAL NR enables comprehensive evaluation of NR ligand polypharmacol.

Scientific Reports published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia