Month: December 2022

Taoda, Yoshiyuki published the artcileDihydrodibenzothiepine: Promising hydrophobic pharmacophore in the influenza cap-dependent endonuclease inhibitor, Application In Synthesis of 2136287-65-3, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(22), 127547, database is CAplus and MEDLINE.

This work describes a set of discovery research studies of an influenza cap-dependent endonuclease (CEN) inhibitors with a carbamoyl pyridone bicycle (CAB) scaffold, particularly dibenzothiepine-substituted pyridotriazinediones such as I. Using influenza CEN inhibitory activity, antiviral activity and pharmacokinetic (PK) parameters as indexes, structure activity relationships (SAR) studies were performed at the N-1 and N-3 positions on the CAB scaffold, which is a unique template to bind two metals. The hydrophobic substituent at the N-1 position is extremely important for CEN inhibitory activity and antiviral activity, and dihydrodibenzothiepine was the most promising pharmacophore. I showed potent virus titer reduction over oseltamivir phosphate in an in vivo mouse model. I served as the lead compound of baloxavir marboxil with a tricyclic scaffold, which was approved in Japan and the USA in 2018.

Bioorganic & Medicinal Chemistry Letters published new progress about 2136287-65-3. 2136287-65-3 belongs to catalysis-chemistry, auxiliary class Fluoride,sulfides,Carboxylic acid,Benzene, name is 3,4-Difluoro-2-((phenylthio)methyl)benzoic acid, and the molecular formula is C9H7NO4, Application In Synthesis of 2136287-65-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xue, Yulan published the artcileFundamental study on the treatment of acid mine wastewater containing iron and sulfate ions by the neutralization-flotation method, Formula: C14H31NO2, the publication is Zhongnan Kuangye Xueyuan Xuebao (1982), 63-9, database is CAplus.

Artificial acidic mine wastewater containing 1000 mg Fe(III)/L and 6000 mg SO₄^2-/L at pH 2.0 is treated with CaCO₃, gypsum, and Fe(OH)₃ and precipitated by neutralization at pH <5.0. By the slow neutralization and aging process with DAA (dodecylammonium?acetate??[2016-56-0]) gypsum can be separated from Fe(OH)₃ by flotation. However, by a rapid neutralization in the presence of 29 mg/L DAA and <29 mg/L starch??[9005-25-8] as flocculant gypsum and Fe(OH)₃ are well separated from each other by flotation and sedimentation, resp. at pH 4.8-5.1 with recoveries of 90 and 92%.

Zhongnan Kuangye Xueyuan Xuebao published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C4H6O3, Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dikhtievskaya, L. V. published the artcileNMR study of micellar structure of higher aliphatic amine solutions, Category: catalysis-chemistry, the publication is Doklady Akademii Nauk BSSR (1987), 31(6), 543-6, database is CAplus.

A ¹H NMR study of 2% amine acetate (dodecyl-, tetradecyl-, hexadecyl, octadecylamine acetate) solutions in D₂O at 30-90¡ã showed that maximum flotation activity occurred at 50-90¡ã for C₁₂ and C₁₄, 40-60¡ã for C₁₆, and 60-80¡ã for C₁₈ amine acetates. Min. activity was observed at 30-40 and 45-60¡ã for C₁₆ and C₁₈ amine acetates, resp.

Doklady Akademii Nauk BSSR published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dikhtievskaya, L. V. published the artcilePMR-spectroscopic study of solubilization of organic compounds by micellar solutions of aliphatic amines, Synthetic Route of 2016-56-0, the publication is Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk (1989), 21-4, database is CAplus.

NMR spectra for aqueous micellar solutions of C₁₂-C₁₈-aliphatic amine acetate surfactants modified by solubilization of oleophilic organic compounds showed that the action of the solubilizate on the structure and ionic-mol. composition of the micellar solutions depended both on the length of the hydrocarbon portion of the surfactant and on the nature of the solubilizate. For C₁₂ and C₁₄ amines, the greatest structure changes were observed during colloidal dissolution of heptanol, caprylic acid, and ¦Á-naphthol. Heptane, naphthalene, and benzene had little or no influence on the micellar structure. C₁₆ and C₁₈ amines were more susceptible to the changes than C₁₂ or C₁₄ amines. In the case of C₁₈ amine, practically all of the solubilizates caused loosening of the micelle and increased ionization of polar groups. In sylvinite ore enrichment by flotation, the addition of oleophilic compounds had the greatest effect on C₁₈ amine in increasing its flotation activity.

Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Synthetic Route of 2016-56-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Imamoto, Tsuneo published the artcileReduction of organic compounds with rare-earth intermetallics containing absorbed hydrogen, Product Details of C15H15OP, the publication is Journal of Organic Chemistry (1987), 52(26), 5695-9, database is CAplus.

The hydrogenation of organic compounds with rare-earth intermetallic hydrides has been investigated. Alkynes, alkenes, aldehydes, ketones, nitriles, imines, and nitro compounds are hydrogenated in excellent yields with LaNi₅H₆ or LaNi_4.5Al_0.5H₅ at 0-60¡ã. The present hydrogenation method has the following characteristic features: (1) The intermetallic compounds (alloys) are not poisoned by compounds containing an amino group or a halogen atom. (2) The alloys can be used repeatedly without decrease in activity. (3) The reaction conditions are mild, and selective hydrogenations of some organic functional groups can be achieved. The reaction mechanism of this hydrogenation is briefly discussed in terms of stereochem. and H/D exchange reactions.

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Product Details of C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Yimu published the artcileSize-Selective Separation of Rare Earth Elements Using Functionalized Mesoporous Silica Materials, COA of Formula: C10H10O6, the publication is ACS Applied Materials & Interfaces (2019), 11(26), 23681-23691, database is CAplus and MEDLINE.

The separation and preconcentration of rare earth elements (REEs) from mineral concentrates in an economically and environmentally sustainable manner are difficult tasks due to their similar physicochem. properties. Herein, a series of tetradentate phenylenedioxy diamide (PDDA) ligands were synthesized and grafted on large-pore three-dimensional KIT-6 mesoporous silica. In solid-phase extraction, the hybrid sorbents enable a size-selective separation of REEs on the basis of the bite angles of the ligands. In particular, smaller REE³⁺ ions are preferentially extracted by KIT-6-1,2-PDDA, whereas light REEs with larger ionic radius are favored by KIT-6-1,3-PDDA. The exposure of bauxite residue digestion solution containing REEs as well as a number of types of competitive ions (including Th and U) to the sorbents results in selective recovery of target REEs. The possibility of regenerating the mesoporous sorbents through a simple loading-stripping-regeneration process is demonstrated over up to five cycles with no significant loss in REE extraction capacity, suggesting adequate chem. and structural stability of the new sorbent materials.

ACS Applied Materials & Interfaces published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, COA of Formula: C10H10O6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mirjalili, Mahtabalsadat published the artcilePharmacological agents for the prevention of colistin-induced nephrotoxicity, COA of Formula: C5H11NO2S, the publication is European Journal of Medical Research (2022), 27(1), 64, database is CAplus and MEDLINE.

Abstract: Background: Colistin is a polymyxin antibiotic which has been used for treatment of Gram-neg. infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-neg. infections and drug-induced toxicity is considered as the main obstacle for using this valuable antibiotic. Results: In total, 30 articles, including 29 animal studies and one clin. trial were included in this study. These compounds, including aged black garlic extract, albumin fragments, alpha lipoic acid, astaxanthin, baicalein, chrysin, cilastatin, colchicine, curcumin, cytochrome c, dexmedetomidine, gelofusine, grape seed proanthocyanidin extract, hesperidin, luteolin, lycopene, melatonin, methionine, N-acetylcysteine, silymarin, taurine, vitamin C, and vitamin E exhibited beneficial effects in most of the published works. Conclusions: In this review, the authors have attempted to review the available literature on the use of several compounds for prevention or attenuation of colistin-induced nephrotoxicity. Most of the studied compounds were potent antioxidants, and it seems that using antioxidants concomitantly can have a protective effect during the colistin exposure.

European Journal of Medical Research published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

McDevitt, John T. published the artcileMolecular Level Control over the Surface and Interfacial Properties of High-T_c Superconductors, Related Products of catalysis-chemistry, the publication is Chemistry of Materials (1996), 8(4), 811-13, database is CAplus.

One of the major stumbling blocks that has plagued the practical utilization and fundamental studies of the high-T_c superconductors has been the poor interfacial properties exhibited by these systems. In order to control the surface characteristics of high-T_c structures, methods for the spontaneous adsorption of amine reagents into cuprate materials have been developed. These monolayer films allow for control of the wetting properties, corrosion resistance, and adhesion characteristics of these superconductors. The mols. form densely packed, highly oriented structures on the high-T_c surfaces as evidenced by contact angle, XPS, x-ray reflectivity, and corrosion resistance measurements. In this paper, dramatic changes in the interfacial reactivity and adhesion properties of the prototypical high-T_c superconductor, YBa₂Cu₃O₇ , following its modification with linear alkylamines and fluorinated alkylamines reagents are described. Thus, mol. level control over important surface and interfacial properties of cuprate superconductors is demonstrated.

Chemistry of Materials published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rivera, Augusto published the artcileCleaner and efficient green chemistry synthesis of N,N’-dibenzyl or N,N’-(2-hydroxybenzyl)-ethane-1,2-diamine,-propane-1,3-diamine and -1,3-diamino-2-propanol, Formula: C16H20N2, the publication is International Journal of Chemistry (Toronto, ON, Canada) (2016), 8(4), 62-68, database is CAplus.

An efficient and highly eco-friendly protocol for the preparation of N,N’-dibenzyl or N,N’-(2-hydroxybenzyl)diamines I [R¹ = O, CH₂, CHOH; R² = H, 2-OH, 4-OCH₃, 4-N(CH₃)₂] via the reduction of the corresponding di-Schiff bases II that produces a good yield using water as a solvent without the need for catalysis or the azeotropic removal of water has been developed. These sym. diimines have been reduced to their corresponding diamines with sodium borohydride using a catalyst- and solvent-free protocol with excellent yield. Mild conditions, high yields, and a simple work-up procedure are the primary benefits of this protocol.

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Whyte, Andrew published the artcileAsymmetric Synthesis of Boryl-Functionalized Cyclobutanols, Name: 3-Benzoylpropionicacid, the publication is ACS Catalysis (2019), 9(10), 9253-9258, database is CAplus.

A diastereo- and enantioselective synthesis of B-containing cyclobutanols is reported. The authors exploit an enantioselective borylcupration to generate a chiral benzylic Cu intermediate that is intercepted with a proximally tethered ketone. The scaffolds contain an all-C quaternary center with a modular boronate moiety which allows access to a variety of synthetically valuable functional groups. This work represents an asym. approach to monocyclic cyclobutanols and highlights the utility of Cu catalysis in the generation of small-sized rings.

ACS Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C5H11NO2S, Name: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia