Month: December 2022

Landini, Dario published the artcileNucleophilic aromatic substitution reactions promoted by aryl and heteroaryl amine nitranions, Name: Bis(4-nitrophenyl)amine, the publication is New Journal of Chemistry (1998), 22(1), 71-74, database is CAplus.

Nucleophilic substitution reaction of Cl in 4-ClC₆H₄NO₂ by N-anions from RNH₂ (R = C₆F₅, 4-O₂NC₆H₄, tetrafluoro-4-pyridyl, 4-NCC₆F₄) to give the corresponding diarylamines was studied in solvents of different polarity (PhMe and DMSO). The reactivity of these nitranions is 2 orders of magnitude higher in DMSO. Such a difference is attributed to the different reacting species (ion pairs vs. free ions in PhMe and DMSO, resp.). The ¦Â_Nu values obtained (0.31 and 0.26), very similar and relatively low, suggest a moderate extent of charge transfer from nucleophile to substrate in the transition state of both systems.

New Journal of Chemistry published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Name: Bis(4-nitrophenyl)amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shan, Shijie published the artcileSelf-Healing, Reprocessable, and Degradable Bio-Based Epoxy Elastomer Bearing Aromatic Disulfide Bonds and Its Application in Strain Sensors, Application In Synthesis of 119-80-2, the publication is ACS Applied Polymer Materials (2021), 3(10), 5115-5124, database is CAplus.

A dicarboxylic acids functional aromatic disulfide (DTSA) and a dimer aliphatic acid (DAA) were used to crosslink epoxidized soybean oil (ESO) to obtain a bio-based epoxy elastomer with comprehensive properties of toughness and stretchability. This work addresses some urgent needs for epoxy networks, such as recyclability, degradability, and mech. properties. Ratios of permanent and dynamic crosslinks were tuned to yield epoxy elastomers with various characteristics. The bio-based epoxy elastomer in this work took advantages of dynamic aromatic disulfide bonds which can rapidly exchange even at room temperature without external stimuli. Therefore, the epoxy elastomer reported here presented almost quant. self-healing efficiency and high recovery in terms of mech. properties after being reprocessed for many times. Besides, incorporation of permanent chem. crosslinks with DAA caused low hysteresis, which made them suitable for fabricating sensitive and durable strain sensor against cyclic strain.

ACS Applied Polymer Materials published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C15H21BO3, Application In Synthesis of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cong, Le Thi Nhi published the artcileTransformation of iso-pentylbenzene by a biofilm-forming strain of Candida viswanathii TH1 isolated from oil-polluted sediments collected in coastal zones in Vietnam, SDS of cas: 1949-41-3, the publication is Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering (2014), 49(7), 777-786, database is CAplus and MEDLINE.

This work is aimed to assess the aerobic biotransformation of a branched side chain alkylbenzene, iso-pentylbenzene, by Candida viswanathii TH1. The yeast Candida viswanathii TH1 isolated from oil-polluted sediments collected in coastal zones in Vietnam exhibited as a strain that could better transform branched aromatic hydrocarbons in biofilm (pellicle) than in planktonic form. During incubation of TH1 as biofilm with iso-pentylbenzene, the seven intermediates produced were benzoic acid, phenylacetic acid, 2-methyl-4-phenyl-butan-1-ol, 2-hydroxy-phenylacetic acid, 2-methyl-4-phenylbutyric acid, succinic acid and iso-valerophenone as revealed by gas chromatog./mass spectra and high-performance liquid chromatog. analyses. The occurrence of these intermediates showed that iso-pentylbenzene could be oxidized not only via mono- but also by a sub-terminal oxidation pathway. This is the first study on iso-pentylbenzene transformation by a biofilm-forming Candida viswanathii strain. The catabolic versatility of the biofilm-forming strain TH1 and its use for mono and sub-terminal oxidation during the transformation of iso-pentylbenzene enhance our understanding of the degradation of branched side chain phenylalkanes and give new insight into the potential role of such species in the transformation of other recalcitrant aromatic compounds

Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, SDS of cas: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gazwi, Hanaa S. S. published the artcileAnalysis of the phytochemicals of Coriandrum sativum and Cichorium intybus aqueous extracts and their biological effects on broiler chickens, SDS of cas: 63-68-3, the publication is Scientific Reports (2022), 12(1), 6399, database is CAplus and MEDLINE.

Spices and herbs can be used as feed additives and viable alternatives to antibiotics in chicken production This study analyzed the phytochems., minerals, and antioxidant activity of aqueous extracts from Coriandrum sativum seeds and Cichorium intybus roots. The effects of different concentrations of C. sativum and C. intybus extracts on blood parameters, growth and carcass traits, biochem. parameters, and antioxidant activity of broiler chicks were also examined The results showed that C. sativum aqueous extract has relatively higher contents of total flavonoids and total phenolic acids than C. intybus aqueous extract Both extracts contain elevated mineral elements, especially iron, potassium, and sodium. Therefore, dietary supplementation of C. sativum seed and C. intybus root extracts could enhance broiler chicken growth performance, carcass characteristics, liver function, lipid profile, and antioxidant status. These extracts could be utilized as natural feed additives and growth promoters for broiler chickens.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Beckmann, Jens published the artcileReaction of (t-Bu₂SnO)₃ with Organohalosilanes. Simple Formation of Open-Chain and Cyclic Stannasiloxanes, Recommanded Product: Difluorodiphenylsilane, the publication is Organometallics (1998), 17(26), 5697-5712, database is CAplus.

The synthesis or in situ formation of the new stannasiloxanes R¹R²Si(OSn-t-Bu₂)₂E (2, R¹ = R² = t-Bu, E = O; 22, R¹ = t-Bu, R² = F, E = O; 23, R¹ = R² = Ph, E = O; 24, R¹ = R² = t-Bu, E = S; 25, R¹ = t-Bu, R² = F, E = S; 26, R¹ = R² = Ph, E = S), t-Bu₂Si[OSn(Cl)-t-Bu₂]₂ (3), t-Bu₂(Cl)SnOSi(X)-t-Bu₂ (4, X = Cl; 12, X = H), t-Bu₂Sn(OSiR¹R²O)₂M (5, R¹ = R² = t-Bu, M = Sn-t-Bu₂; 7, R¹ = R² = Ph, M = Sn-t-Bu₂; 9, R¹ = R² = Ph, M = SiPh₂; 18, R¹ = t-Bu, R² = Cl, M = Sn-t-Bu₂; 21, R¹ = t-Bu, R² = F, M = Sn-t-Bu₂), t-Bu₂Sn(OSiXR₂)₂ (10, X = H, R = t-Bu; 11, X = F, R = t-Bu; 13, X = F, R = Et; 14, X = F, R = i-Pr; 15, X = F, R = Ph), t-Bu₂Sn(OSiX₂-t-Bu)₂ (16, X = Cl; 19, X = F), t-Bu₂ClSnOSiCl₂-t-Bu (17), [R¹R²Si(OSn-t-Bu₂)₂O.t-Bu₂SnX₂] (20, R¹ = t-Bu, R² = F, X = F; 27, R¹ = t-Bu, R² = F, X = OH; 28, R¹ = R² = Ph, X = OH), O(t-Bu₂SnOSiPh₂)₂O (29), t-Bu₂Sn(OSiMe₂CH₂)₂ (30), and t-Bu₂SnOSiF-t-BuOSn-t-Bu₂OSit-Bu₂O (31) is described. The compounds were characterized by multinuclear NMR spectroscopy and Moessbauer spectroscopy. The mol. structures of the eight-membered stannasiloxane rings 5, 7, 9, 21, and 29 were determined by x-ray anal. On the basis of NMR and electrospray mass spectrometry a mechanism is proposed involving protonated species for the redistribution reaction between 5 and 21.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karishma, Pidiyara published the artcileReducing-Agent-Free Convergent Synthesis of Hydroxyimino-Decorated Tetracyclic Fused Cinnolines via Rh^III-Catalyzed Annulation Using Nitroolefins, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Journal of Organic Chemistry (2021), 86(3), 2734-2747, database is CAplus and MEDLINE.

A mild Rh-catalyzed method was developed for the synthesis of hydroxyimino functionalized indazolo[1,2-a]cinnolines and phthalazino[2,3-a]cinnolines by reductive [4 + 2] annulation between 1-arylindazolones and 2-aryl-2,3-dihydrophthalazine-1,4-diones with varied nitroolefins. The targeted oxime decorated tetracyclic fused cinnolines were synthesized via sequential C-H activation/olefin insertion/reduction under reducing-agent-free conditions.

Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saeed, Aamer published the artcileSynthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2014), 43-53, database is CAplus and MEDLINE.

The present study reports the synthesis of cinnamides I [R = 4-ClC₆H₄, 3-O₂NC₆H₄, 2-F-6-ClC₆H₃, etc.] and their biol. activity as inhibitors of both cholinesterases and anticancer agents. Controlled inhibition of brain acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may slow neurodegeneration in Alzheimer’s diseases (AD). The anticholinesterase activity of phenylcinnamide derivatives was determined against Elec. Eel acetylcholinesterase (EeAChE) and horse serum butyrylcholinesterase (hBChE) and some of the compounds appeared as moderately potent inhibitors of EeAChE and hBChE. Compound I [R = 2-(PhCH₂O)C₆H₄] showed maximum activity against EeAChE with an IC₅₀ 0.29¡À0.21 ¦ÌM whereas I [R = 2-Cl-6-NO₂C₆H₃] was proved to be the most potent inhibitor of hBChE having IC₅₀ 1.18¡À1.31 ¦ÌM. To better understand the enzyme-inhibitor interaction of the most active compounds toward cholinesterases, mol. modeling studies were carried out on high-resolution crystallog. structures. The anticancer effects of synthesized compounds were also evaluated against cancer cell line (lung carcinoma). The compounds may be useful leads for the design of a new class of anticancer drugs for the treatment of cancer and cholinesterase inhibitors for Alzheimer’s disease.

European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rueda-Becerril, Montserrat published the artcileDirect C-F Bond Formation Using Photoredox Catalysis, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of the American Chemical Society (2014), 136(6), 2637-2641, database is CAplus and MEDLINE.

We have developed the first example of a photoredox catalytic method for the formation of carbon-fluorine (C-F) bonds. The mechanism has been studied using transient absorption spectroscopy and involves a key single-electron transfer from the ³MLCT (triplet metal-to-ligand charge transfer) state of Ru(bpy)₃²⁺ to Selectfluor. Not only does this represent a new reaction for photoredox catalysis, but the mild reaction conditions and use of visible light also make it a practical improvement over previously developed UV-mediated decarboxylative fluorinations.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gholamalian, Reihaneh published the artcileHepatic fatty acids profile, oxidative stability and egg quality traits ameliorated by supplementation of alternative lipid sources and milk thistle meal, SDS of cas: 6217-54-5, the publication is Journal of Animal Physiology and Animal Nutrition (2022), 106(4), 860-871, database is CAplus and MEDLINE.

This study assessed the effects of different levels of milk thistle (Silybum marianum) meal (MTM) on egg quality traits, oxidative stability, blood biochem. parameters and liver health indexes in laying hens receiving diets supplemented with lipid from different sources. For this purpose, Leghorn laying hens (Hy-Line W-36) were randomly assigned to 12 exptl. treatments with eight replicates of five birds each. Dietary treatments consisted of four dietary fat sources (fish oil, sunflower oil, poultry oil and fat powder, each with different fatty acid profiles) and three levels of MTM (0.0, 15 and 30 g/kg) offered through 10 days of adaptation and 70 days of main recording. Results showed that dietary inclusion of polyunsaturated fatty acids, including fish or sunflower oils, reduced serum cholesterol content but increased blood malondialdehyde (MDA) concentration (p < 0.05). While fish oil improved the yolk color index and Haugh unit (p < 0.05), it decreased yolk cholesterol concentration (p < 0.01). The highest hepatic glycogen content and tissue integrity as well as the lowest liver lipid percentage and MDA content were observed in birds fed diets supplemented with poultry oil. On the other hand, feeding 30 g/kg of MTM reduced not only hepatic lipid percentage but also aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities (p < 0.01), while it improved eggshell strength and thickness (p < 0.05). Supplementation of fat powder enhanced hepatic C16:0 content, while addition of poultry, sunflower or fish oil increased C18:1, C18:2 or C20:5 concentrations resp. (p < 0.01); nonetheless, feeding the highest level of MTM reduced hepatic ¦²SFA but increased ¦²n-3 fatty acids (p < 0.01). The interaction effects indicated that fish or sunflower oil supplementation increased the MTM level required to reduce not only serum or egg cholesterol concentrations (p < 0.05) but also blood or hepatic MDA content (p < 0.01). It was concluded that fish oil and MTM (30 g/kg) supplements might improve internal egg quality traits and eggshell quality resp. The hepatic fatty acid profile was also found strongly correlated with dietary fatty acids. Finally, the best hepatic health indexes and the highest oxidative stability were achieved when the birds were fed diets supplemented with poultry oil and 30 g/kg of MTM.

Journal of Animal Physiology and Animal Nutrition published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, SDS of cas: 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Kyeojin published the artcileGlucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C₁₇-side chain, Related Products of catalysis-chemistry, the publication is European Journal of Medicinal Chemistry (2014), 184-194, database is CAplus and MEDLINE.

A series of glucal-conjugated sterols as novel vascular leakage blocker were identified through design, synthesis and biol. evaluation. In addition, the structure-activity relationship (SAR) of the glucal-conjugated sterols focusing on the C₁₇-side chain was also established. The sterol analogs linked with the rigid C₁₇-side chain side chains exhibited potent cell survival activities. In particular, ((2R,3S)-3-Acetoxy-6-((3S,10R,13S,17S)-17-((E)-1-(cyclopentyloxyimino)ethyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy)3,6-dihydro-2H-pyran-2-yl)methyl acetate, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacol. effects on retinal vascular leakage in a diabetic mouse model.

European Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia