Catalysis-chemistry

Han, Hee Oon published the artcileDesign and synthesis of oxime ethers of ¦Á-acyl-¦Â-phenylpropanoic acids as PPAR dual agonists, Safety of O-Isobutylhydroxylamine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(4), 937-941, database is CAplus and MEDLINE.

Oxime ethers of ¦Á-acyl-¦Â-phenylpropanoic acids, e.g., I, were prepared to apply as PPAR¦Á and ¦Ã dual agonists. Among them, I proved to exhibit potent in vitro activities with EC₅₀ of 19 and 13 nM in PPAR¦Á and ¦Ã, resp. It showed better glucose lowering effects than rosiglitazone and ameliorated the lipid profile like plasma triglyceride in db/db mice model.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Safety of O-Isobutylhydroxylamine hydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Jee-Hyun published the artcileSynthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/¦Â-catenin pathway, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(15), 3529-3532, database is CAplus and MEDLINE.

We synthesized (+)-decursin derivatives substituted with cinnamoyl- and Ph propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound I, in which a 3-acetoxy cinnamoyl group was introduced, most potently inhibited (97.0%) the Wnt/¦Â-catenin pathway. Specifically, compound I dose-dependently inhibited Wnt3a-induced expression of the ¦Â-catenin response transcription (CRT) and increased ¦Â-catenin degradation in HEK293 reporter cells. Furthermore, compound I suppressed expression of the downstream ¦Â-catenin target genes cyclin D1 and c-myc and suppressed PC3 cell growth in a concentration-dependent manner.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Daniel, Alyssa published the artcileAbraham model correlations for solute transfer into cyclopentanone, Product Details of C8H8O2, the publication is Physics and Chemistry of Liquids, database is CAplus.

Mole fraction solubilities have been measured for anthracene, benzoic acid, 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 2-hydroxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 3-nitrobenzoic acid and pyrene dissolved in cyclopentanone at 298.15 K using either spectrophotometric or acid-base titrimetric methods. Results of our exptl. measurements, combined with published solubility data for several inorganic and organic gases, solubility data for several important crystalline pharmaceutical intermediates and activity coefficient data taken from the published literature, were used to derive Abraham model correlations for solute transfer into anhydrous cyclopentanone solvent from both water and from the gas phase. The derived Abraham model correlations back-calculate the observed exptl. data to within 0.10 log units (or less). Reported for the first time are solute descriptor values for several important pharmaceutical intermediates.

Physics and Chemistry of Liquids published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Product Details of C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Seo, Seon-Mi published the artcileStructure-Activity Relationship of Aliphatic Compounds for Nematicidal Activity against Pine Wood Nematode (Bursaphelenchus xylophilus), Product Details of C10H15NS, the publication is Journal of Agricultural and Food Chemistry (2010), 58(3), 1823-1827, database is CAplus and MEDLINE.

Nematicidal activity of aliphatic compounds was tested to determine a structure-activity relationship. There was a significant difference in nematicidal activity among functional groups. In a test with alkanols and 2E-alkenols, compounds with C₈-C₁₁ chain length showed 100% nematicidal activity against pine wood nematode, Bursaphelenchus xylophilus, at 0.5 mg/mL concentration C₆-C₁₀ 2E-alkenals exhibited >95% nematicidal activity, but the other compounds with C₁₁-C₁₄ chain length showed weak activity. Nematicidal activity of alkyl acetates with C₇-C₁₁ chain length was strong. Compounds belonging to hydrocarbons, alkanals, and alkanoic acetates showed weak activity at 0.5 mg/mL concentration Nematicidal activity of active compounds was determined at lower concentrations At 0.25 mg/mL concentration, whole compounds except C₈ alkanol, C₈ 2E-alkenol, and C₇ alkanoic acid showed >80% nematicidal activity. C₉-C₁₁ alkanols, C₁₀-C₁₁ 2E-alkenols, C₈-C₉ 2E-alkenals, and C₉-C₁₀ alkanoic acids showed >80% nematicidal activity at 0.125 mg/mL concentration Only C₁₁ alkanol exhibited strong nematicidal activity at 0.0625 mg/mL concentration, the lowest concentration that was tested.

Journal of Agricultural and Food Chemistry published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C18H20N2O12, Product Details of C10H15NS.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Seol Rin published the artcile2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists, HPLC of Formula: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(11), 2080-2083, database is CAplus and MEDLINE.

In order to replace thiourea group with the more drug-like moiety for 1,3-dibenzylthioureas having TRPV1 antagonist activity, we introduced a set of functional groups between the two aromatic rings based on bioisosteric replacement. The synthesized bioisosteres of 1,3-dibenzylthioureas were tested for their antagonist activities on TRPV1 by ⁴⁵Ca²⁺-influx assay using neonatal rat cultured spinal sensory neurons. Among the tested 14 kinds of bioisosters, 2-methylacrylamide group was the best candidate to replace thiourea group. Compound 7c, 2-methylacrylamide analog of ATC-120, showed as potent as ATC-120 in its antagonist activity. In addition, 2-methylacrylamide analog 7e having vinyl moiety showed the most potent activity with 0.022¦ÌM of IC₅₀ value, indicating that thiourea group of 1,3-dibenzylthioureas could be replaced to 2-methylacrylamide without loss of their potencies.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ha, Eun Kyo published the artcilePersonal exposure to total VOC is associated with symptoms of atopic dermatitis in schoolchildren, Safety of 2-Methylbenzoic acid, the publication is Journal of Korean Medical Science (2022), 37(8), e63, database is CAplus and MEDLINE.

The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with pos. SCORAD index values (defined as SCORAD ¡Ý 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and pos. SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and pos. SCORAD results. Conclusion: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Journal of Korean Medical Science published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Jimin published the artcileBoron Lewis Acid-Catalyzed Hydrophosphinylation of N-Heteroaryl-Substituted Alkenes with Secondary Phosphine Oxides, Related Products of catalysis-chemistry, the publication is Journal of Organic Chemistry (2020), 85(23), 15476-15487, database is CAplus and MEDLINE.

The authors report the B-catalyzed hydrophosphinylation of N-heteroaryl-substituted alkenes with secondary phosphine oxides that furnishes various P-containing N-heterocycles. This process proceeds under mild conditions and enables the introduction of a P atom into multisubstituted alkenylazaarenes. The available mechanistic data can be explained by a reaction pathway wherein the C-P bond is created by the reaction between the activated alkene (by coordination to a B catalyst) and the P(III) nucleophile (in tautomeric equilibrium with phosphine oxide).

Journal of Organic Chemistry published new progress about 23897-16-7. 23897-16-7 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Dimesitylphosphine oxide, and the molecular formula is C18H23OP, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Taelim published the artcileIdentification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(7), 1844-1848, database is CAplus and MEDLINE.

In this study, a series of bis(4-hydroxy)benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have addnl. and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chae, Weon-Sik published the artcileHelix-coiled gold nanowires for molecular sensing, Category: catalysis-chemistry, the publication is Journal of Nanoscience and Nanotechnology (2012), 12(4), 3501-3505, database is CAplus and MEDLINE.

Helix-coiled gold nanowires were fabricated by a templating route using unique composite templates consisting of anodic aluminum oxide (AAO) nanotubular membrane and confined mesoporous silica therein. A different degree of confinement energy induces a different degree of helix curvature of confined porous silica nanochannels in an AAO, which works as a hard template for the electrochem. deposition of gold, thereby rationally enabling a different degree of helix curvature of gold nano-replicas. From surface-enhanced Raman scattering experiments, it was first found that helix-coiled gold nanowires show more distinctly enhanced mol. sensing efficiency than those from simple smooth gold nanowires, and gold nanowires with the narrower lateral width show more enhanced mol. sensing efficiency than those of thicker width helix nanowires.

Journal of Nanoscience and Nanotechnology published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ryan, Michael C. published the artcilePiperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones, Related Products of catalysis-chemistry, the publication is ACS Medicinal Chemistry Letters (2022), 13(4), 546-553, database is CAplus and MEDLINE.

While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-treated, 2-dihalomethylquinolinones unexpectedly afforded ring-expanded piperazine-fused benzodiazepinones I [R¹ = NO₂, F, CN; R² = H, NO₂; R³ = H, Br, 2-morpholinyl, etc.; R⁴ = Me, Bn; R⁵ = Me, cyclohexyl, Bn; Ar = Ph, 4-MeOC₆H₄, 4-FC₆H₄, etc.]. Notably, this new chemotype showed potent, submicromolar inhibition of virus-induced cell death, >7-log reduction of viral yield, and tractable structure-activity relationships across both viruses. Antiviral activity was confirmed in primary human neuronal cells. A mechanistic rationale for product formation is proposed, and key structural elements were comparatively modeled between a similarly substituted antiviral amidine and piperazinobenzodiazepinone prototypes to guide future antiviral development.

ACS Medicinal Chemistry Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia