Catalysis-chemistry

Kim, Dong CHan published the artcileSynthesis of new thiazolium betaines and the ring expansion reaction via 1,4-dipolar cycloaddition, Category: catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (1995), 32(5), 1581-6, database is CAplus.

The 1,4-dipolar cycloaddition of 3-phenyl-7-[N-phenyl(carbamoyl)]-5,6-dihydroimidazo[2,1-b]thiazolium betaine (I) with a series of aliphatic alkylating agents such as Et bromoacetate, ¦Á-chloroacetone, and Et 4-chloroacetoacetate gave a variety of new ring-expanded cycloadducts. E.g., (12RS,13SR)-12-acetyl-2,4-dioxo-1,3,9-triphenyl-6,7-dihydro-12H-thiazino[3′,4′:2,3]imidazo[1,2-a][1,3,5]triazine was prepared in 38% yield from I and ¦Á-chloroacetone.

Journal of Heterocyclic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Misra, Santosh K. published the artcileA dual strategy for sensing metals with a nano ‘pincer’ scavenger for in vitro diagnostics and detection of liver diseases from blood samples, Product Details of C6H20Cl2N4, the publication is Colloids and Surfaces, B: Biointerfaces (2015), 444-451, database is CAplus and MEDLINE.

This work presents a dual, non-invasive approach for the detection of elevated level of metals in patients with liver disease. A highly sensitive, small mol. ‘pincer’ scavenger was synthesized for the detection and quantification of copper in serum and systemically in vivo. For the in vitro diagnostics, the developed technique involves only a routine capillary blood sampling or venipuncture, removing the need for invasive biopsies. The organic scavenger mol. showed high specificity toward copper ions, with a detection sensitivity of 1.35 ¡Á 10^-2 ¦Ìg/L in mouse serum. Furthermore, for the systemic detection of copper in the liver, a polymeric nanopincer has been designed and studied. The small mol. scavengers were stably incorporated into polymeric micelles via its long acyl chains and polymeric micelle proved to be a stable carrier when injected into mice i.v. The organic scavenger mol. was found to be highly fluorescent and specific toward Cu²⁺ and can potentially help ameliorate diseases regarding accretion of copper in certain vital organs. The strategy and the results provide a novel, non-invasive dual nanomedicine approach for the early detection and treatment of excessive metal deposits in the human organs.

Colloids and Surfaces, B: Biointerfaces published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Product Details of C6H20Cl2N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mirzaei-Kalar, Zeinab published the artcileNew ZnFe₂So₄;@SiO₂@graphene quantum dots as an effective nanocarrier for targeted DOX delivery and CT-DNA binder, Related Products of catalysis-chemistry, the publication is Journal of Molecular Liquids (2022), 119904, database is CAplus.

The current study pronounces the synthesis and characterization of ZnFe₂O₄, ZnFe₂So₄@SiO₂, graphene quantum dots (GQDs) and ZnFe2O4@SiO2@GQDs nanoparticles by different techniques such as VSM, XRD, IR, UV-Vis and SEM. For application in targeted drug delivery, then GQDs were immobilized on the surface ZnFe₂So₄@SiO₂ via covalent linkage to surface amino groups. The competence of ZnFe₂So₄@SiO₂@GQDs nanoparticles was assessed by loading and releasing of doxorubicin (DOX) as a standard anticancer drug at pH = 5 (pH of cancerous cell) and pH = 7.4 (pH of healthy cell). The attained results authenticate the pH sensitive release behavior of ZnFe₂So₄@SiO₂@GQDs nanoparticles by releasing more DOX at cancerous pH (70%) than healthy pH (28%). To appraise the biol. manner, ZnFe₂So₄@SiO₂@GQDs nanoparticles were screened for their CT-DNA binding tendency by means of spectroscopic methods. The gained results of absorption spectroscopy and competitive fluorescence studies disclosed that nanoparticles bind to DNA through the intercalation mode and the loading of DOX on the nanocarrier has increased CT-DNA binding affinity up to 300 times. The cytotoxicity activity of ZnFe₂So₄@SiO₂@GQDs and ZnFe₂So₄@SiO₂@GQDs/DOX by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed on cancerous HeLa cell and healthy HEK-293 cell revealed that both nanoparticles exhibit concentration-dependent behavior on both cell lines, so that with increasing nanoparticle concentration, the cell viability percentage decreases, although nanocarriers containing DOX expression a more severe effect. Treatment of HeLa cells with 10 ¦Ìg/mL of the ZnFe₂So₄@SiO₂@GQDs/DOX nanoparticles showed that the nanoparticles induce cell death by apoptosis and cause detention of cell cycle in G2 phase. The results of the study expression the potential of the nanocarrier for targeted and controlled drug delivery, which should be given more attention and modified as a nanocarrier.

Journal of Molecular Liquids published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sadrara, Mina published the artcileFabrication of highly mesoporous ZSM-48 zeolite by anionic surfactant-organosilane system for catalytic conversion of methanol to gasoline, Category: catalysis-chemistry, the publication is Solid State Sciences (2022), 106888, database is CAplus.

A highly mesoporous ZSM-48 zeolite has been prepared using low-cost anionic surfactant sodium dodecylsulfate (SDS) as mesopore-generating agent and short-chain 3-aminopropyltrimethoxysilane (APTMS) as co-structure directing agent. The mesoporosity formation took place through the interaction between the silica species/APTMS and SDS mols. existing in the gel composition In the synthesis solution with a pH slightly less than ten, the methoxysilyl moiety in APTMS was hydrolyzed to the -SiO3 units and became incorporated inside the zeolite crystals while the pos. charged ammonium site of APTMS interacted with the neg. charged head group of the SDS. Aggregation of aluminosilicate/APTMS species around the SDS micelles during the crystallization process, led to the formation of a mesoporous zeolite. In this study, a conventional ZSM-48 and seven ZSM-48 zeolites from different mixtures containing SDS, APTMS and SDS-APTMS with different APTMS/SiO2 molar ratios were synthesized. Changes in the properties of the synthesized samples were investigated by XRD, FTIR, SEM, TEM, nitrogen adsorption/desorption isotherms, NH3-TPD and TGA. The optimum ZSM-48/Sur/0.008OS zeolite prepared with APTMS/SiO2 molar ratio of 0.008 exhibited both bundled needle-like and spherical morphologies. The catalytic conversion of methanol to gasoline (MTG) was evaluated in a fixed-bed reactor, and the results revealed that mesoporosity development using Sur-OS system enhanced catalytic activity of ZSM-48/Sur/0.008OS catalyst compared to the other sample. The optimum zeolite showed long stable phase of 40 h and liquid hydrocarbon yield of 42% was achieved for 100% methanol conversion in 22 h of reaction. The proposed method opens a new and simple route for the synthesis of hierarchically porous ZSM-48 with tunable porosity using low-cost anionic surfactants.

Solid State Sciences published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khosropour, Ahmad Reza published the artcileSynthesis of trans-cinnamic acids from aryl aldehydes and aryl aldehyde bisulfite adducts with malonic acid using piperazine, Category: catalysis-chemistry, the publication is Journal of Chemical Research (2005), 364-365, database is CAplus.

Piperazine as a new reagent for the condensation of aryl aldehydes and their bisulfite adducts with malonic acid are described which afford the corresponding cinnamic acids in excellent yields and short reaction times in the absence of solvents under microwave irradiation

Journal of Chemical Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Traboulsi, Hassan published the artcileStructure-Based Epitope Design: Toward a Greater Antibody-SARS-CoV-2 RBD Affinity, Recommanded Product: Fmoc-Pro-OH, the publication is ACS Omega (2021), 6(47), 31469-31476, database is CAplus and MEDLINE.

Efficient COVID-19 vaccines are widely acknowledged as the best way to end the global pandemic. SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to cell infection. Antibodies could be developed to target RBD and represent a potential approach for the neutralization of the virus. Epitopes used to produce antibodies are generally linear peptides and thus possess multiple confirmations that do not reflect the actual topol. of the targeted part in the native protein. On the other hand, macrocyclic epitopes could constitute closer mimics of the native protein topol. and, as such, could generate superior antibodies. We demonstrated the vital effect of the size and the 3-dimensional shape of epitopes on the activity of the developed antibodies against the RBD of SARS-CoV-2. The mol. dynamics studies showed the greater stability of the cyclic epitopes compared with the linear counterparts, which was reflected in the affinity of the produced antibodies. The antibodies developed using macrocyclic epitopes showed superiority with respect to binding to RBD compared to antibodies formed from linear peptides. This study constitutes a roadmap for developing superior antibodies that could be used to inhibit the activity of SARS-CoV-2.

ACS Omega published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C11H12O4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shamsipur, Mojtaba published the artcileThe synthesis of 1,4-diaza-2,3;8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione and its use in calcium-selective carbon paste electrodes, Category: catalysis-chemistry, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2001), 40(4), 303-307, database is CAplus.

A synthetic procedure was developed for the preparation of 1,4-diaza-2,3;8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione. A C paste electrode based on the new macrocyclic diamide was constructed for Ca²⁺ determination The calibration graph was linear over a wide concentration range (1.3 ¡Á 10^-6-3.2 ¡Á 10^-3 M) with a near Nernstian slope of 32 mV decade^-1. The limit of detection is 7.9 ¡Á 10^-7 M (0.032 ppm). Selectivity coefficients were tabulated and the working pH range was determined It has a fast response time of <10 s and can be used for at least 3 mo without any considerable divergence in potentials. The electrode was successfully applied to the determination of Ca²⁺ ions in a pharmaceutical preparation

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C18H22O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kubczak, Malgorzata published the artcileHippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity, Synthetic Route of 63-68-3, the publication is Scientific Reports (2022), 12(1), 1095, database is CAplus and MEDLINE.

Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the human diet. Growing demands for these compounds make it important to seek new sources for them. Hippophae rhamnoides L. is known as a plant with health-promoting properties. In this study we investigated the chem. composition and biol. properties of bioactive components of ethanol extracts from leaves and twigs of H. rhamnoides L. Chem. components such as the total content of phenolic compounds, vitamins and amino acids and the antioxidant activities of these compounds in cellular and cell-free systems were assessed. The results suggest that the studied extracts are rich in bioactive compounds with potent antioxidant properties. Cytotoxicity and hemotoxicity assays showed that the extracts had low toxicity on human cells over the range of concentrations tested. Interaction with human serum albumin was investigated and conformational changes were observed Our results indicate that leaf and twig extracts of H. rhamnoides L. should be considered as a non-toxic source of bioactive compounds which may be of interest to the food, pharmaceutical and cosmetic industries.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Synthetic Route of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Malik, Sameena N. published the artcileNano catalytic ozonation of biomethanated distillery wastewater for biodegradability enhancement, color and toxicity reduction with biofuel production, Computed Properties of 14707-75-6, the publication is Chemosphere (2019), 449-461, database is CAplus and MEDLINE.

The effectiveness of O₃, O₃/Fe²⁺, and O₃/nZVI processes on biomethanated distillery wastewater (BMDWW) was evaluated in terms of biodegradability index (BI) enhancement, biofuel production, COD, color, and toxicity reduction A significant increase in biodegradability, COD, color, and toxicity reduction was observed in O₃/nZVI compared with O₃ and O₃/Fe²⁺ due to more hydroxyl radical production The O₃/nZVI pretreated wastewater with enhanced BI (up to 0.71) showed 60% COD removal with addnl. biogas generation (64% methane content). From gas chromatog.-mass spectrometric (GC-MS) anal., 18 foremost organic compounds were predominantly detected in the raw distillery wastewater. The disappearance of the corresponding FTIR (Fourier transform IR spectroscopy) and GC-MS spectra during pretreatment processes signified the degradation or transformation of the recalcitrant present in the distillery wastewater. Subsequent (AnO + AO, AO) of pretreated BMDWW resulted in biodegradation rate enhancement by (1.83, 1.67), (3.5, 2.4) and (4.7, 2.9) times for O₃, O₃/Fe²⁺, and O₃/nZVI processes, resp.

Chemosphere published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Computed Properties of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alsharif, Meshari A. published the artcilePharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is ChemistrySelect (2020), 5(2), 498-505, database is CAplus.

A series of 3-nitro-2-phenyl-2H-chromenes I (R = 4-fluorophenyl, 2-nitrophenyl, naphthalen-1-yl, etc.; R¹ = H, 3-OMe, 4-Me; R² = 3-OMe, 4-F, 4-Cl, etc.) has been synthesized, characterized and tested for their inhibition potential and binding affinity with the CAMKIV. Among the synthesized compounds, the IC₅₀ value (50% of ATPase activity) for compounds I (R = 2-nitrophenyl, R¹ = H, R² = 4-F; R = 4-chlorophenyl, R¹ = 4-Me, R² = H) was observed as 12.22 ¡À 1.12¦ÌM and 16.10 ¡À 1.30¦ÌM resp. The fluorescence binding and dot-blot assay further complements inhibitory potential, indicating a better binding affinity. These compounds were tested against human cancerous cells (HepG2) and observed a significant inhibition of cell viability, induced apoptosis and lowered tau-phosphorylation. In cell viability studies, the IC₅₀ values for compounds I (R = 2-nitrophenyl, R¹ = H, R² = 4-F; R = 4-chlorophenyl, R¹ = 4-Me, R² = H) were 18.33 ¡À 1.12 and 26.22 ¡À 1.30¦ÌM resp. These results suggested that the compounds I (R = 2-nitrophenyl, R¹ = H, R² = 4-F; R = 4-chlorophenyl, R¹ = 4-Me, R² = H) are non-toxic to the normal cells and specifically inhibit the proliferation of cancerous cells.

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia