Catalysis-chemistry

Shander, Aryeh published the artcileDrug-induced anemia and other red cell disorders: a guide in the Ag of polypharmacy, Application of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Current Clinical Pharmacology (2011), 6(4), 295-303, database is CAplus and MEDLINE.

A review. Several medications have been linked to red blood cell (RBC) disorders. The frequency of these side effects varies, depending on the condition, but they can be associated with significant morbidity and mortality. The problem is likely to exacerbate in aging populations with frequent comorbidities, proportional to the growing number of medications used. Notable drug-related RBC disorders include hemolytic anemia, megaloblastic anemia, sideroblastic anemia, polycythemia, methemoglobinemia, anemia of irritation/inflammation, and anemia caused by suppression of RBC production The list of medications that are associated with these disorders is long and includes many commonly-used drugs. This could pose a challenge in timely diagnosis and management of these disorders. Prior knowledge of the potential for drug-related RBC disorders and monitoring the patients who are being treated with medications known to cause RBC disorders are critical to ensure timely and effective response, should such adverse reactions occur.

Current Clinical Pharmacology published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C8H12BNO2, Application of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shi, Caihua published the artcileActivated release of hexanal and salicylaldehyde from imidazolidine precursors encapsulated in electrospun ethylcellulose-poly(ethylene oxide) fibers, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is SN Applied Sciences (2021), 3(3), 385, database is CAplus.

Hexanal and salicylaldehyde are naturally-occurring antimicrobial volatiles from edible plants known for their efficacy for post-harvest preservation of fruits and vegetables. Due to their volatility and susceptibility to oxidation, these volatiles must be encapsulated within a carrier to control their release, especially when applied in modified atm. and active packaging applications. In this study, salicylaldehyde precursor (SP; 1,3-dibenzylethane-2-hydroxyphenyl imidazolidine) and hexanal precursor (HP) were synthesized through a Schiff base reaction between these aldehydes and N,N’-dibenzylethane-1,2-diamine. The structure of SP was confirmed using NMR and attenuated total reflection-Fourier transform IR (FTIR) spectroscopies. SP and HP, sep. and in combinations, were encapsulated within ethylcellulose-poly(ethylene oxide) (EC-PEO) nonwoven membranes, using a free-surface electrospinning technique. SEM showed that the morphol. of the fibers varied substantially with SP and HP ratio. Specific interactions between SP and HP with the polymers were not detected from the FTIR spectroscopy anal., suggesting that the precursors were mainly phys. entrapped within the EC-PEO fiber matrix. Headspace gas chromatog. showed that the release of hexanal and salicylaldehyde could be activated by contacting the precursor-containing electrospun nonwoven with an acidified agarose gel containing 0.003-0.3 M of citric acid. The delivery system can be promising for controlled release of hexanal and salicylaldehyde to extend the shelf-life of fruits and vegetables.

SN Applied Sciences published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C7H14N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Silviana, S. published the artcileSynthesis of Aminopropyl-Functionalized Mesoporous Silica Derived from Geothermal Silica for an Effective Slow-Release Urea Carrier, Formula: C6H17NO3Si, the publication is Industrial & Engineering Chemistry Research (2022), 61(26), 9283-9299, database is CAplus.

An effective method to prepare slow-release urea was developed with aminopropyl-functionalized mesoporous silica (MS) to achieve enhanced urea adsorption and slow-release properties. As a novel study, mesoporous silica was developed using treated geothermal silica as the silica source, cetyltrimethylammonium bromide (CTAB) as the surfactant, and 3-aminopropyl trimethoxy silane (APTMS) as the surface modification agent. Mesoporous silica with the most desirable properties of uniform micromorphol. containing 38.55 wt % silica particles, 668.849 m²/g surface area, 149.33-353.28 mL/g adsorption-desorption range, and 0.26 mL/g adsorption pore volume was achieved using 0.05 mol of CTAB. The synthesized mesoporous silica showed type-IV hysteresis, which corresponds to mesoporous materials. Differential scanning calorimetry (DSC)-thermogravimetric anal. (TGA) thermograms showed that mesoporous silica is more reactive, with peaks at 82.3 and 159.5 ¡ãC, has good thermal stability, and undergoes only 17.61% weight loss until 124 ¡ãC. SEM (SEM) showed that functionalization and urea adsorption to mesoporous silica resulted in no significant morphol. changes. In the Fourier transform IR (FTIR) spectra, MS/APTMS/U26.74 was observed to have higher intensities of C=O, N-H, C-N, and C-H groups compared with other samples. The cumulative urea release during 7 days was 184.5 ppm (92.4%) for com. urea and 124.6 ppm (64.4%) for MS/APTMS/U26.74. The Higuchi kinetic model yielded the best fit predicting MS/APTMS/U26.74 release kinetics, with an R² of 0.9979 and a Higuchi constant of 24.4964%/day. Finally, MS/APTMS/U26.74 synthesized using geothermal silica, CTAB, and APTMS was noted to possess a potential composition for slow-release urea with enhanced efficiency.

Industrial & Engineering Chemistry Research published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C10H16Br3N, Formula: C6H17NO3Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hou, Jian published the artcileSystematic incorporation of gold nanoparticles onto mesoporous titanium oxide particles for green catalysts, Application In Synthesis of 613-33-2, the publication is Catalysts (2021), 11(4), 451, database is CAplus.

This report describes the systematic incorporation of gold nanoparticles (AuNPs) onto mesoporous TiO₂ (MPT) particles without strong attractive forces to efficiently serve as reactive and recyclable catalysts in the homocoupling of arylboronic acid in green reaction conditions. Unlike using nonporous TiO₂ particles and conventional SiO₂ particles as supporting materials, the employment of MPT particles significantly improves the loading efficiency of AuNPs. The incorporated AuNPs are less than 10 nm in diameter, regardless of the amount of applied gold ions, and their surfaces, free from any modifiers, act as highly reactive catalytic sites to notably improve the yields in the homocoupling reaction. The overall phys. properties of the AuNPs integrated onto the MPT particles are thoroughly examined as functions of the gold content, and their catalytic functions, including the rate of reaction, activation energy, and recyclability, are also evaluated. While the rate of reaction slightly increases with the improved loading efficiency of AuNPs, the apparent activation energies do not clearly show any correlation with the size or distribution of the AuNPs under our reaction conditions. Understanding the formation of these types of composite particles and their catalytic functions could lead to the development of highly practical, quasi-homogeneous catalysts in environmentally friendly reaction conditions.

Catalysts published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Application In Synthesis of 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sivaperumal, R. published the artcileStudy of fiber delamination on silane modified ramie fiber/ OMMT nano-clay epoxy composite under low-velocity impact, shear load, and high-speed drilling, Related Products of catalysis-chemistry, the publication is Polymer Composites (2022), 43(7), 4280-4287, database is CAplus.

In this present study, the effect of silane treated ramie fiber addition along with organically-modified montmorillonite (OMMT) nano clay in epoxy resin composite was investigated in drop load impact, shear loading, and high-speed drilling. The main aim of this research study was to develop a high-laminar shear strength epoxy structural composite for various engineering applications. To improve the laminar adhesion the fiber was treated using silane via acid hydrolysis technique. The OMMT nanoclay also added with fiber in order to improve the load bearing effect and adhesion phenomenon. The composites were prepared using hand layup method with postcuring. The adhesion behavior of composites was tested based on American society for testing and materials standards and compared. According to the results, the treated ramie fiber possesses high resistance to impact loading. The ballistic resistance of composite is increased three fold when compare with as-received fiber-epoxy composites. The interlaminar shear strength of composite designation C1.5 gives highest shear strength of 35 MPa. The drilling study revealed highest dimensional stability for treated fiber. No fiber chip off and pull out at the drilled hole surface. The fractog. anal. confirms no lamina delamination occurs even at high-speed drilling. These delamination resistance epoxy-based composites are suitable in automobile, structural and defense gadget manufacturing applications.

Polymer Composites published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C8H6ClN, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Manna, Srimanta published the artcileSynthesis of (E)-nitroolefins via decarboxylative nitration using t-butylnitrite (t-BuONO) and TEMPO, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(46), 5286-5288, database is CAplus and MEDLINE.

Nitroolefins are usually synthesized using the Henry reaction. Here, the authors report an alternative metal-free decarboxylative nitration protocol for the preparation of the nitroolefins from ¦Á,¦Â-unsaturated carboxylic acids using tert-butylnitrite (t-BuONO) and TEMPO. ¦Á,¦Â-Unsaturated carboxylic acids bearing ¦Â-aromatic and ¦Â-heteroaromatic substituents gave (E)-nitroolefins exclusively under mild conditions. A radical based pathway has been proposed for this decarboxylative nitration reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Zhiguo published the artcileEnantioselective synthesis of 2-aryl-3-nitro-2H-chromenes catalyzed by a bifunctional thiourea, Formula: C10H11NO4, the publication is Synlett (2011), 1262-1264, database is CAplus.

A bifunctional thiourea-catalyzed tandem approach of oxa-Michael-aza-Henry-desulfonamidation was used to synthesize chiral 2-aryl-3-nitro-2H-chromenes. This method provides direct access to the corresponding products in moderate to good yields and enantioselectivities.

Synlett published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H12O6, Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hearn, Brian R. published the artcileStructure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is ChemMedChem (2016), 11(8), 870-880, database is CAplus and MEDLINE.

The integrated stress response (ISR) comprises multiple signaling pathways for detecting and responding to cellular stress that converge at a single event – the phosphorylation of Ser51 on the ¦Á-subunit of eukaryotic translation initiation factor 2 (eIF2¦Á). Phosphorylation of eIF2¦Á (eIF2¦Á-P) results in attenuation of global protein synthesis via the inhibitory effects of eIF2¦Á-P on eIF2B, the guanine exchange factor (GEF) for eIF2. Herein we describe structure-activity relationship (SAR) studies of bis-O-arylglycolamides, first-in-class integrated stress response inhibitors (ISRIB). ISRIB analogs make cells insensitive to the effects of eIF2¦Á-P by activating the GEF activity of eIF2B and allowing global protein synthesis to proceed with residual unphosphorylated eIF2¦Á. The SAR studies described herein support the proposed pharmacol. of ISRIB analogs as binding across a sym. protein-protein interface formed between protein subunits of the dimeric eIF2B heteropentamer.

ChemMedChem published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hernandez-Coronado, Marcela published the artcileSuccessful second outpatient autologous hematopoietic cell transplant for relapsed POEMS syndrome in a patient with coexisting HIV, HBV and syphilis infections during the COVID-19 pandemic, HPLC of Formula: 140-28-3, the publication is Transplant Immunology (2021), 101412, database is CAplus and MEDLINE.

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a multisystem autoinflammatory disease due to an underlying plasma cell disorder that lacks a standard treatment strategy because of its rarity. We report a case of relapsed POEMS syndrome successfully treated with a second ambulatory autologous hematopoietic-cell transplantation (AHCT) after a daratumumab desensitization protocol performed during the coronavirus disease (COVID-19) pandemic in a patient with coexisting human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis infections. He is a 37-yr old Latin-American male who had been treated with radiation, CyBorD regimen, AHCT and bortezomib therapy before being referred to our service. It was decided to administer daratumumab therapy and subsequently perform the transplant. Placement of central venous access, fluid infusion, conditioning regimen with melphalan and previously cryopreserved autograft infusion were carried out in an outpatient basis. Following second AHCT, the patient demonstrated clin., VEGF, hematol. response and remains SARS-CoV-2 infection-free and in POEMS remission with excellent quality-of-life at last follow up (6 mo). We evidenced that thanks to an outpatient transplant program, the best therapeutic modalities can be offered to patients with hematol. malignancies in the context of present or future pandemics. Finally, high-complexity patients with HIV infection should have access to the same treatment strategies as non-infected patients. A second AHCT in the outpatient setting is feasible, safe and highly effective to treat patients with relapsed POEMS syndrome.

Transplant Immunology published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Papo, Tshephiso R. published the artcileTuning the ¦Ð-backbonding and ¦Ò-trans effect of N?N? coordinated Pt(II) complexes. Kinetic and computational study, Recommanded Product: 1,1-Dimethylthiourea, the publication is Journal of Coordination Chemistry (2015), 68(5), 794-807, database is CAplus.

The nucleophilic substitution reaction of cyclometalated substituted 2,6-dipyridylphenyl platinum complexes [PtLⁿCl] (n = 1-4; HL¹ = 1,3-di-2-pyridylbenzene; HL² = 1-fluoro-3,5-di-2-pyridylbenzene; HL³ = 1-fluoro-2,4-di-2-pyridylbenzene; HL⁴ = 1-methyl-3,5-di-2-pyridylbenzene) with thioureas R¹R¹NCSNR²R² (TU, R¹ = R² = H; DMTU, R¹ = Me, R² = H; TMTU, R¹ = R² = Me) as a series of neutral nucleophiles with different steric properties, was studied under pseudo-first-order conditions in methanol solution of an ionic strength of 0.1 M (0.09 M LiOTf and 0.01 M LiCl). The rate of substitution of the chloro ligand was studied as a function of nucleophile concentration and temperature using UV-visible and stopped-flow spectrophotometric techniques. The observed pseudo-first-order rate constants for the substitution reactions obey the rate law k_obs = k₂[Nu] + k_-2. The reactivity of the investigated complexes when [PtL¹Cl] is used as a reference follows the order [PtL²Cl] > [PtL³Cl] > [PtL⁴Cl] > [PtL¹Cl]. The lability of the chloro group is dependent on the extent of ¦Ð-backbonding and the ¦Ò-trans effect of the ligand backbone. [PtL²Cl] and [PtL³Cl], which have a common electron-withdrawing fluoride on the ligand trans to the leaving group, have a higher reaction rate compared to [PtL⁴Cl], which has an electron-donating Me group attached to the ligand backbone. The position of the substituent on the Ph group trans to the leaving group also influences the overlap of frontier MOs which result in controlling the reactivity of the fluoro complexes. In general, the results show that the nature of the substituent, either electron withdrawing or electron donating, results in an increase in the rate of substitution. Second-order kinetics and large neg. activation entropies (¦¤S^#) support an associative substitution mechanism. The exptl. data are supported by DFT calculations

Journal of Coordination Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia