Catalysis-chemistry

Gao, Bao published the artcileCopper-catalyzed decarboxylative cross-coupling of cinnamic acids and ACCN via single electron transfer, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2016), 14(8), 2399-2402, database is CAplus and MEDLINE.

A novel and convenient method for the synthesis of ¦Â,¦Ã-unsaturated nitriles using ACCN (1,1′-azobis(cyclohexane-1-carbonitrile)) as a cyano source was described. This reaction was amenable to a broad range of substrates and provided the desired ¦Â,¦Ã-unsaturated nitriles containing an all-carbon quaternary carbon center in moderate yields with high selectivity via single electron transfer and decarboxylation.

Organic & Biomolecular Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Bo published the artcileOrganocatalytic Morita-Baylis-Hillman/Michael/Acetalization Cascade: Procedure-Controlled Diastereodivergence in the Asymmetric Synthesis of Fully Substituted Tetrahydropyrans, Related Products of catalysis-chemistry, the publication is Advanced Synthesis & Catalysis (2014), 356(17), 3676-3682, database is CAplus.

The authors accomplished a controlled diastereodivergence in the asym. synthesis of fully functionalized tetrahydropyrans I (R¹ = C₆H₅, 2-ClC₆H₄, 2,4-Cl₂C₆H₃, 2-thienyl, etc., R² = OC₂H₅, CH₃, R³ = CH₃, C₂H₅, n-Pr) by adjusting the sequence of an organocatalytic cascade reaction. The one-pot operation provides two synthetically important architectures with excellent stereocontrol. This is the first published kinetic resolution of MBH alcs. in an organocascade.

Advanced Synthesis & Catalysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Su, Xiang published the artcileA sustainable [P_6,6,6,14]₂[OPBOA]-based separation process of rare earth and transition metal in waste NiMH battery, Application of 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Minerals Engineering (2021), 106641, database is CAplus.

The separation of rare earth (RE) and transition metals is a critical step in the recycling of nickel-metal hydride (NiMH) battery. From the point of environmental and practical issues, an ionic liquid (IL) [trihexyl(tetradecyl)phosphonium]₂[2,2¡ä-(1,2-phenylenebis(oxy))dioctanoate] ([P_6,6,6,14]₂[OPBOA]) was newly synthesized for the separation of RE from transition metals in NiMH batteries leachate. The separation factors of ¦ÂNd/Co and ¦ÂNd/Ni could arrive at 5.2 x 10³ and 5.4 x 10³, resp. Meanwhile, the extracted Ni(II) and Co(II) could be effectively scrubbed and stripped by 0.5 mol/L sodium chloride (NaCl) solution without loss of RE. The loaded Nd(III) in [P_6,6,6,14]₂[OPBOA] could be quant. stripped by 0.014 mol/L hydrochloric acid (HCl), 0.016 mol/L sodium oxalate (Na₂C₂O₄) or 0.022 mol/L sodium carbonate (Na₂CO₃). [P_6,6,6,14]₂[OPBOA] could be recycled without regeneration when Na₂C₂O₄ and Na₂CO₃ were used as stripping agents and larger precipitated particle size could be obtained by low-concentration Na₂CO₃ solution In the process of separating rare earth and transition metal from NiMH battery, even to handle 500 mL feed solution, the recovery efficiency and purity of RE in NiMH batteries could still reach more than 96.4% and 99.8 wt% by using NaCl and Na₂CO₃ for stripping, resp. As characterized by XRD, the recovered RE oxides could be easily obtained by calcinations.

Minerals Engineering published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C5H6BNO3, Application of 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yongkang published the artcileFirst total syntheses of 1-benzoyl-3,4-dihydroisoquinoline alkaloids Nelumstemine and Longifolonine based on the photo-oxidation, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Youji Huaxue (2020), 40(5), 1281-1289, database is CAplus.

A novel synthetic route for the total syntheses of 1-benzoyl-3,4-dihydroisoquinoline alkaloids was developed. Nelumstemine was synthesized for the first time via 6 steps in 50% overall yield starting from 3,4-dimethoxybenzaldehyde, and Longifolonine was also synthesized for the first time via 9 steps in 35% overall yield starting from vanillin. The key step of these total syntheses is photo-oxidation of 1-benzyl-3,4-dihydroisoquinolines to 1-benzoyl-3,4-dihydroisoquinolines by air under visible-light irradiation at room temperature The unique mild photo-oxidation of 1-benzyl-3,4-dihydro-isoquinolines has been studied in detail.

Youji Huaxue published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Junkai published the artcileIdentification of new potent anticancer derivatives through simplifying the core structure and modification on their 14- hydroxyl group from oridonin, Quality Control of 118-90-1, the publication is European Journal of Medicinal Chemistry (2022), 114155, database is CAplus and MEDLINE.

The natural product oridonin has the potential to be a broad-spectrum antineoplastic agent. To develop oridonin analogs with high potency, a series of novel oridonin analogs were designed and synthesized by removing the multiple hydroxyl groups of parent compound The representative analogs 14, 19, and 26 (I – III, resp.) exhibited potent anticancer effects against K562, MDA-MB-231, SMMC-7721, and MCF-7 cells. Further structural modification on their 14-OH generated more potent derivatives 16n, 21d, and 28d, resp. (IV – VI, resp.), in which the IC₅₀ value of compound 16n was 50-fold more potent than parent oridonin in K562 cells. Furthermore, compound 16n significantly induced the cell cycle arrest of K562 cells at the G2 phase and increased the fraction of apoptotic cells. Importantly, compounds 16n, 21d, and 28d exhibited good antitumor activities in H22 allograft mice in vivo. These results suggest that compounds 16n, 21d, and 28d deserve further development as promising candidates for the treatment of cancers.

European Journal of Medicinal Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cai, Mingzhong published the artcileRecyclable palladium-catalyzed Suzuki coupling of aromatic triazine esters: A practical one-pot synthesis of aryl ketones from aromatic acids, Application of 2-Methylbenzoic acid, the publication is Synthetic Communications (2022), 52(7), 1079-1090, database is CAplus.

An efficient heterogeneous palladium-catalyzed Suzuki coupling of aromatic triazine esters I (Ar = 4-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) with arylboronic acids Ar¹B(OH)₂ (Ar¹ = Ph, 3,5-dichlorophenyl, furan-2-yl, etc.) has been developed. The reaction proceeds smoothly in toluene at 110¡ãC using 2 mol% of MCM-41-bound bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)₂] as catalyst and provides a novel and practical method for the synthesis of aryl ketones ArC(O)Ar¹ starting from readily available aromatic acids ArCOOH in a one-pot procedure with moderate to excellent yields. The MCM-41-2P-Pd(OAc)₂ catalyst can be reused at least seven times without any apparent decrease in its catalytic activity.

Synthetic Communications published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Application of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiao, Guiying published the artcileNickel-Catalyzed Asymmetric Hydrogenation of ¦Ã-Keto Acids, Esters, and Amides to Chiral ¦Ã-Lactones and ¦Ã-Hydroxy Acid Derivatives, Recommanded Product: 3-Benzoylpropionicacid, the publication is Organic Letters (2022), 24(14), 2722-2727, database is CAplus and MEDLINE.

A highly efficient asym. hydrogenation of a series of ¦Ã-keto acid derivatives, including ¦Ã-keto acids RC(O)CH₂CH₂C(O)OH (R = Me, Ph, cyclopentyl, 3,4-dimethylphenyl, etc.), esters RC(O)CH₂CH₂C(O)OR¹ (R¹ = Me, Et, t-Bu), and amides RC(O)CH₂CH₂C(O)NR²R³ (R² = H, Bn, iPr; R³ = H, iPr), using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral ¦Ã-hydroxy acid derivatives RCH(OH)CH₂CH₂C(O)OR¹ and RCH(OH)CH₂CH₂C(O)NR²R³ with excellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis of chiral ¦Ã-lactones I but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate for pharmaceutical synthesis.

Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C6H3BrFNO, Recommanded Product: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cao, Fangyuan published the artcileHDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway, Quality Control of 104-03-0, the publication is Bioorganic Chemistry (2021), 105396, database is CAplus and MEDLINE.

Non-small-cell lung carcinoma (NSCLC) is one of the most common forms of lung cancer, and a leading cause of cancer death among human beings. There is an urgent demand for novel therapeutics for the treatment of NSCLC to enhance the efficacy of the currently applied Tyrosine kinase inhibitors (TKIs) therapy and to overcome therapy-resistance. Here, we report a novel small-mol. inhibitor that simultaneously targets histone deacetylase (HDAC) and macrophage migration inhibitory factor (MIF). The HDAC/MIF dual inhibitor proved to be toxic for EGFR mutated (H1650, TKI-resistant) or knock out (A549 EGFR-/-) NSCLC cell lines. Further experiments showed that HDAC inhibition inhibits cell survival and proliferation, while MIF inhibition downregulates pAKT or AKT expression level, which both interfere with cell survival. Furthermore, the combination treatment of TKI and HDAC/MIF dual inhibitor showed that the dual inhibitor enhanced TKI inhibitory efficacy, highlighting the advantages of HDAC/MIF dual inhibitor for more effective treatment of NSCLC.

Bioorganic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Quality Control of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Bing published the artcileBeneficiation technology study and industrial practice of high-mud sulfide-oxide Pb-Zn ore, Formula: C14H31NO2, the publication is Kuangye (Beijing, China) (2017), 26(1), 32-37, database is CAplus.

The beneficiation technol. study on a high-mud sulfide-oxide Pb-Zn ore in the Lanping area, Yunnan is presented in this paper. Based on the process mineralogy study and considering difficulties associated with conventional processing methods, a combination process of gravity-concentration-and floatation, which includes predesliming, recovering of zinc oxide from muddy by gravity concentration, lead and zinc sulfides floatation followed by oxides flotation, was determined The study used a centrifuge to recover zinc oxide effectively, and the new combined collectors improved the floatability of zinc oxide in flotation processes. The full set of technol. was successfully applied to the mine production, and achieved excellent industrial production indexes.

Kuangye (Beijing, China) published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Deng, Jinfeng published the artcileIodine promoted reduction of aromatic carbonyl compounds with phosphonic acid to access hydrocarbons, Application of Bis(4-fluorophenyl)methane, the publication is Tetrahedron (2022), 132755, database is CAplus.

A novel method for selective reduction of aromatic carbonyl compounds by phosphorus acid under metal-free conditions was achieved to produce the corresponding reduced products in good to excellent yields. By using H₃PO₃/I₂ system, various aromatic ketones and aldehydes were reduced to the corresponding hydrocarbons. Diketone compounds were also be reduced to the corresponding Z-alkenes. The protocol is low-cost and easily scaled up, which provided a simple and practical approach to access corresponding hydrocarbons.

Tetrahedron published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Application of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia