Catalysis-chemistry

Xiao, Wu-Yi published the artcileClick Reaction-Assisted Peptide Immune Checkpoint Blockade for Solid Tumor Treatment, Name: Dbco-maleimide, the publication is ACS Applied Materials & Interfaces (2020), 12(36), 40042-40051, database is CAplus and MEDLINE.

One of the major challenges of immune checkpoint blockade (ICB) is the poor penetration of antibody for solid tumor treatment. Herein, peptides with deeper penetration capability are used to develop a click reaction-assisted peptide immune checkpoint blockade (CRICB) strategy that could in situ construct assemblies, enabling enhanced accumulation and prolonged PD-L1 occupancy, ultimately realizing high-performance tumor inhibition. First, the free DBCO-modified targeting peptide (TP) efficiently recognizes and binds PD-L1 in a deep solid tumor. Upon a reagent-free click reaction with a subsequently introduced azide-tethered assembled peptide (AP), the click reaction results in spontaneous self-aggregation in situ with enhanced accumulation and prolonged occupancy. In addition, the penetration of TP-AP (121.2 ¡À 15.5¦Ìm) is significantly enhanced compared with that of an antibody (19.9 ¡À 5.6¦Ìm) in a solid tumor tissue. More importantly, significant immunotherapy effects and negligible side effects are observed in 4T1 and CT26 tumor-bearing mice models treated with TP-AP, suggesting the high-performance tumor inhibition attributed to the CRICB strategy. In summary, this CRICB strategy manifest the preferable effects of immune checkpoint blockade, thereby extending the biomedical application of assembling peptides.

ACS Applied Materials & Interfaces published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C18H26ClN3O, Name: Dbco-maleimide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kou, Huizhi published the artcileA new macrocyclic heterobinuclear Cu(II)-Zn(II) complex: synthesis, crystal structure, phosphate hydrolysis, and DNA binding studies, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Journal of Coordination Chemistry (2019), 72(10), 1683-1696, database is CAplus.

A new macrocyclic heterobinuclear Cu(II)-Zn(II) complex was synthesized and characterized by elemental anal., FTIR, ES-MS, and single-crystal x-ray diffraction. Five-coordinate geometry for the new complex is proposed. The Cu…Zn distance bridged by two phenolic oxygens and a acetate ligand is 2.9508 ?. The phosphate ester hydrolysis activity and the DNA binding ability of the complex were studied. The present complex has an efficient catalytic activity of phosphoester bond cleavage. The catalytic rate constant k_cat for the hydrolysis of 4-nitrophenyl phosphate disodium salt hexahydrate (pNPP) by the synthesized complex is 2.69 ¡Á 10^-4 s^-1 and 10⁵ times faster than the spontaneous hydrolysis of the phosphate monoester. The complex shows a good binding ability to calf thymus (CT-DNA) and the corresponding binding constant is 1.9 ¡Á 10⁵ M^-1. The linear Stern-Volmer quenching constant obtained by the fluorescent spectroscopic is 6.3 ¡Á 10⁴ M^-1.

Journal of Coordination Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ding, Peipei published the artcileSynthesis of heterobinuclear Cu(II)-Ni(II) complex: Structure, CT-DNA interaction, hydrolytic function and antibacterial studies, HPLC of Formula: 140-28-3, the publication is Journal of Molecular Structure (2019), 836-843, database is CAplus.

A new benzyls pendant-armed macrobicyclic heterbinuclear Cu(II)-Ni(II) complex has been obtained by template-directed synthesis and characterized by elemental anal., IR spectra, electrospray mass spectra, and single crystal x-ray diffraction. The complex was bridged by two phenolic oxygens and an acetate radical, with the Cu(II)-Ni(II) distance of 2.9292(8) ?. The hydrolytic function, CT-DNA binding and antibacterial properties were also studied. The initial rate values for the hydrolysis of 4-nitrophenylphosphate to 4-nitrophenolate by the Cu(II)-Ni(II) complex was 1.33 ¡Á 10^-5 s^-1, and 10⁴ times faster than that the spontaneous hydrolysis of the phosphate monoester. The complex shows a better binding property to CT-DNA and the intrinsic binding constant is 1.29 ¡Á 10⁵ M^-1. The Stern-Volmer constant is 1.25 ¡Á 10⁵ M^-1. The viscosity increased obviously with the increase of complex concentration, the results showed that the complex bind to DNA through intercalation mode, which was in accordance with the absorption and emission spectral studies. The antibacterial activities against E.coli was also investigated using the Gentamycinas reference system.

Journal of Molecular Structure published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qiu, Xu published the artcileSelective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents: A Direct Approach to Anilines, HPLC of Formula: 1293990-73-4, the publication is Chinese Journal of Chemistry (2021), 39(11), 3011-3016, database is CAplus.

Herein, a novel method for the preparation of anilines ArNH₂ (Ar = 4-methylphenyl, naphthalen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) from alkylarenes ArCH₂CH₃ via Schmidt-type rearrangement using redox-active amination reagents RONH₂⁺R¹.^–OTf (R = Ns, Ts, tert-butylcarbonyl; R¹ = H, Me, i-Pr), which are easily prepared from hydroxylamines R¹NHOH was reported. Primary amines ArNH₂ and secondary amines ArNHR¹ were prepared from corresponding alkylarenes or benzyl alcs. ArCH(OH)CH₃ under mild conditions. Good compatibility and valuable applications of the transformation were also displayed.

Chinese Journal of Chemistry published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, HPLC of Formula: 1293990-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zheng published the artcileDesign, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2015), 23(20), 6666-6672, database is CAplus and MEDLINE.

The free fatty acid receptor 1 (FFA1) has attracted extensive attention as a novel antidiabetic target in the last decade. Several FFA1 agonists reported in the literature have been suffered from relatively high mol. weight and lipophilicity. We have previously reported the FFA1 agonist 1. Based on the common amide structural characteristic of SAR1 and NIH screened compound, we here describe the continued structure-activity exploration to decrease the mol. weight and lipophilicity of the compound 1 series by converting various amide linkers. All of these efforts lead to the discovery of the preferable lead compound 18, a compound with considerable agonistic activity, high LE and LLE values, lower lipophilicity than previously reported agonists, and appreciable efficacy on glucose tolerance in both normal and type 2 diabetic mice.

Bioorganic & Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lv, Qiang published the artcileLattice-mismatch-free growth of organic heterostructure nanowires from cocrystals to alloys, Recommanded Product: Coronene, the publication is Nature Communications (2022), 13(1), 3099, database is CAplus and MEDLINE.

Organic heterostructure nanowires, such as multiblock, core/shell, branch-like and related compounds, have attracted chemists¡ä extensive attention because of their novel physicochem. properties. However, owing to the difficulty in solving the lattice mismatch of distinct mols., the construction of organic heterostructures at large scale remains challenging, which restricts its wide use in future applications. In this work, we define a concept of lattice-mismatch-free for hierarchical self-assembly of organic semiconductor mols., allowing for the large-scale synthesis of organic heterostructure nanowires composed of the organic alloys and cocrystals. Thus, various types of organic triblock nanowires are prepared in large scale, and the length ratio of different segments of the triblock nanowires can be precisely regulated by changing the stoichiometric ratio of different components. These results pave the way towards fine synthesis of heterostructures in a large scale and facilitate their applications in organic optoelectronics at micro/nanoscale.

Nature Communications published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lam, Ying-Pong published the artcileAmide/Iminium Zwitterionic Catalysts for (Trans)esterification: Application in Biodiesel Synthesis, Product Details of C10H10O3, the publication is ACS Catalysis (2019), 9(9), 8083-8092, database is CAplus.

A class of zwitterionic organocatalysts based on an amide anion/iminium cation charge pair has been developed. The zwitterions are easily prepared by reacting aziridines with aminopyridines. They are catalytically applicable to transesterifications and dehydrative esterifications. Mechanistic studies reveal that the amide anion and iminium cation work synergistically in activating the reaction partners, with the iminium cationic moiety interacting with the carbonyl substrates through nonclassical hydrogen bonding. The reaction can be applied to large-scale synthesis of biodiesel under mild conditions.

ACS Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Product Details of C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tai, Xi-Shi published the artcileSynthesis, structural characterization and electrochemical property of a dinuclear Cu (II) complex material, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid, the publication is Open Materials Science Journal (2015), 210-213, database is CAplus.

A novel dinuclear Cu(II) complex material has been synthesized by the reaction of 1, 2-phenylenedioxydiacetic acid, 1,10-phenantroline (phen) and Cu(CH₃COO)₂¡¤H₂O. And it has been characterized by elemental anal., IR, UV and single crystal X-ray diffraction. The crystal belongs to tetragonal, space group I4₁/a with a = b = 25.381(4) ?, c = 32.044(6) ?, V = 20643(6) ?³, Z = 16, Dc= 1.395 g¡¤cm^-3, ¦Ì = 0.898 mm^-1, F (000) = 8896, and final R = 0.1026, ¦ØR = 0.3142. The structural anal. shows that two Cu(II) atoms adopt different coordination modes, Cu¹ has five-coordination with a trigonal bipyramidal configuration, and Cu² has four-coordination with a distorted square planar configuration. The cyclic voltammetric behavior of the dinuclear Cu(II) complex has been investigated.

Open Materials Science Journal published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C7H4BrClO2, Name: 2,2-(1,2-Phenylenebis(oxy))diacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kostelnik, Thomas I. published the artcileRapid Thermodynamically Stable Complex Formation of [^nat/111In]In³⁺, [^nat/90Y]Y³⁺, and [^nat/177Lu]Lu³⁺ with H₆dappa, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Inorganic Chemistry (2020), 59(10), 7238-7251, database is CAplus and MEDLINE.

A phosphinate-bearing picolinic acid-based chelating ligand (H₆dappa) was synthesized and characterized to assess its potential as a bifunctional chelator (BFC) for inorganic radiopharmaceuticals. NMR spectroscopy was employed to investigate the chelator coordination chem. with a variety of nonradioactive trivalent metal ions (In³⁺, Lu³⁺, Y³⁺, Sc³⁺, La³⁺, Bi³⁺). D. functional theory (DFT) calculations explored the coordination environments of aforementioned metal complexes. The thermodn. stability of H₆dappa with four metal ions (In³⁺, Lu³⁺, Y³⁺, Sc³⁺) was deeply investigated via potentiometric and spectrophotometric (UV-vis) titrations, employing a combination of acidic in-batch, joint potentiometric/spectrophotometric, and ligand-ligand competition titrations; high stability constants and pM values were calculated for all four metal complexes. Radiolabeling conditions for three clin. relevant radiometal ions were optimized ([¹¹¹In]In³⁺, [¹⁷⁷Lu]Lu³⁺, [⁹⁰Y]Y³⁺), and the serum stability of [¹¹¹In][In(dappa)]^3- was studied. Through concentration-, time-, temperature-, and pH-dependent labeling experiments, it was determined that H₆dappa radiolabels most effectively at near-physiol. pH for all radiometal ions. Furthermore, very rapid radiolabeling at ambient temperature was observed, as maximal radiolabeling was achieved in less than 1 min. Molar activities of 29.8 GBq/¦Ìmol and 28.2 GBq/¦Ìmol were achieved for [¹¹¹In]In³⁺ and [¹⁷⁷Lu]Lu³⁺, resp. For H₆dappa, high thermodn. stability did not correlate with kinetic inertness-lability was observed in serum stability studies, suggesting that its metal complexes might not be suitable as a BFC in radiopharmaceuticals. Thermodn. stability of H₆dappa metal complexes is very high, most notably In³⁺-dappa (left); radiolabeling of H₆dappa is rapidly occurring in just 1 min at room temperature with a host of radionuclides-shown here is labeling data with [¹⁷⁷Lu]Lu³⁺ (right).

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Chao published the artcileSilver-Catalyzed Decarboxylative Radical Azidation of Aliphatic Carboxylic Acids in Aqueous Solution, Computed Properties of 1949-41-3, the publication is Journal of the American Chemical Society (2015), 137(31), 9820-9823, database is CAplus and MEDLINE.

We report herein an efficient and general method for the decarboxylative azidation of aliphatic carboxylic acids. Thus, with AgNO₃ as the catalyst and K₂S₂O₈ as the oxidant, the reactions of various aliphatic carboxylic acids with tosyl azide or pyridine-3-sulfonyl azide in aqueous CH₃CN solution afforded the corresponding alkyl azides under mild conditions. A broad substrate scope and wide functional group compatibility were observed A radical mechanism is proposed for this site-specific azidation.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia