Catalysis-chemistry

Kormachev, V. V. published the artcilePhosphorus-containing intermediates and dyes. IX. Syntheses based on aryldichloro- and diarylchlorophosphines, Formula: C15H15OP, the publication is Zhurnal Obshchei Khimii (1988), 58(4), 770-6, database is CAplus.

Bis(aminoaryl)alkylphosphine oxide intermediates for azo dyes were obtained in high yields by addition of alkyl halides to chlorodiarylphosphines, conversion of the crystalline dihalophosphorane intermediates to phosphine oxides with alcs., nitration of the phosphine oxides, and reduction of the nitro groups. The reaction of bis[2-(N-ethyl-N-phenylamino)ethyl] phenylphosphonite with EtI occurred under mild conditions only at the P atom to give 2-(N-ethyl-N-phenylamino)ethyl ethylphenylphosphinate. Azo coupling of the P-containing primary and tertiary aromatic amines gave new types of dyes with good dyeing properties.

Zhurnal Obshchei Khimii published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Henning, Ryan K. published the artcileDegradation of Akt using protein-catalyzed capture agents, Safety of Dbco-maleimide, the publication is Journal of Peptide Science (2016), 22(4), 196-200, database is CAplus and MEDLINE.

Abnormal signaling of the protein kinase Akt has been shown to contribute to human diseases such as diabetes and cancer, but Akt has proven to be a challenging target for drugging. Using iterative in situ click chem., we recently developed multiple protein-catalyzed capture (PCC) agents that allosterically modulate Akt enzymic activity in a protein-based assay. Here, we utilize similar PCCs to exploit endogenous protein degradation pathways. We use the modularity of the anti-Akt PCCs to prepare proteolysis targeting chimeric mols. that are shown to promote the rapid degradation of Akt in live cancer cells. These novel proteolysis targeting chimeric mols. demonstrate that the epitope targeting selectivity of PCCs can be coupled with non-traditional drugging moieties to inhibit challenging targets.

Journal of Peptide Science published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C25H21N3O4, Safety of Dbco-maleimide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mateus-Fontecha, Lady published the artcileUnderstanding aerosol composition in a tropical inter-Andean valley impacted by agro-industrial and urban emissions, Safety of Coronene, the publication is Atmospheric Chemistry and Physics (2022), 22(13), 8473-8495, database is CAplus.

Agro-industrial areas are frequently affected by various sources of atm. pollutants that have a neg. impact on public health and ecosystems. However, air quality in these areas is infrequently monitored because of their smaller population compared to large cities, especially in developing countries. The Cauca River valley (CRV) is an agro-industrial region in southwestern Colombia, where a large fraction of the area is devoted to sugarcane and livestock production The CRV is also affected by road traffic and industrial emissions. This study aims to elucidate the chem. composition of particulate matter fine mode (PM_2.5) and to identify the main pollutant sources before source attribution. A sampling campaign was carried out at a representative site in the CRV region, where daily averaged mass concentrations of PM_2.5 and the concentrations of water-soluble ions, trace metals, organic and elemental carbon, and various fractions of organic compounds (carbohydrates, n alkanes, and polycyclic aromatic hydrocarbons – PAHs) were measured. The mean PM_2.5 was 14.4 ¡À 4.4¦Ìg m^-3, and the most abundant constituent was organic material (52.7% ¡À 18.4%), followed by sulfate (12.7% ¡À 2.8%), and elemental carbon (7.1% ¡À 2.5%), which indicates the presence of secondary aerosol formation and incomplete combustion. Levoglucosan was present in all samples, with a mean concentration of (113.8 ¡À 147.2 ng m^-3), revealing biomass burning as a persistent source. Mass closure using the elemental carbon (EC) tracer method explained 88.4% on PM_2.5, whereas the organic tracer method explained 70.9% of PM_2.5. We attribute this difference to the lack of information of specific organic tracers for some sources, both primary and secondary. Organic material and inorganic ions were the dominant groups of species (79% of PM_2.5). OMprim and OMsec contribute 24.2% and 28.5% to PM_2.5. Inorganic ions as sulfate, nitrate, and ammonia constitute 19.0%, EC 7.1%, dust 3.5%, particle-bounded water (PBW) 5.3%, and trace element oxides (TEOs), 0.9% of PM_2.5. The aerosol was acidic, with a pH of 2.5 ¡À 0.4, mainly because of the abundance of organic and sulfur compounds Diagnostic ratios and tracer concentrations indicate that most PM_2.5 was emitted locally and had contributions of both pyrogenic and petrogenic sources, that biomass burning was ubiquitous during the sampling period and was the main source of PAHs, and that the relatively low PM_2.5 concentrations and mutagenic potentials are consistent with low-intensity, year-long biomass burning (BB) and sugarcane pre-harvest burning in the CRV.

Atmospheric Chemistry and Physics published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Safety of Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Naciuk, Fabricio F. published the artcileOne pot domino reaction accessing ¦Ã-nitroesters: synthesis of GABA derivatives, Related Products of catalysis-chemistry, the publication is New Journal of Chemistry (2015), 39(3), 1643-1653, database is CAplus.

Michael addition of 1,3-dicarbonyl compounds to nitrostyrenes is efficiently promoted by hydrotalcite [Mg-Al] to afford the resp. ¦Ã-nitrodicarbonyl adducts. Differently, the addition of Meldrum’s acid leads to a direct access of ¦Ã-nitroesters through a one pot domino process. GABA derivatives (+/-)-phenibut and (+/-)-baclofen were readily synthesized from the resp. nitro adducts.

New Journal of Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sunitha, Pg published the artcileDevelopment of novel stability indicating RP-HPLC method for quantification of trientine hydrochloride and characterization of its degradation product by spectroscopic techniques, Application In Synthesis of 38260-01-4, the publication is Research Journal of Pharmaceutical, Biological and Chemical Sciences (2019), 10(3), 211-223, database is CAplus.

The present work reports the development of a novel stability indicating RP-HPLC method for the quantification of Trientine hydrochloride. The stability of Trientine hydrochloride was studied under different stress conditions recommended by ICH guidelines. Trientine contains amino group which makes it vulnerable to oxidative degradation The chromatog. separation of the drug and its degradation product was achieved in a Waters Reliant C8 column (250mm ¡Á 4.0mm ID, 4¦Ìm particle size) employing gradient elution using Acetronitrile and Ammonium formate buffer at pH 5.3 ¡À 0.05 (90:10) volume/volume, at a flow rate of 0.8mL/min and detection performed at 220 nm. The develop method has been validated as per ICH guidelines. Structural characterization and identification of the degradation product was done by LC-MS, 1H NMR, 13C NMR and IR spectroscopic studies. Toxicity prediction for the degradation product was achieved using the Software OSIRIS.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C7H7ClN2S, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sunitha, P. G. published the artcileValidated RP-HPLC PDA method for estimation of trientine hydrochloride in pharmaceutical dosage form, Synthetic Route of 38260-01-4, the publication is International Journal of ChemTech Research (2019), 12(1), 87-92, database is CAplus.

The present work reports a reverse phase high performance liquid chromatog. (RP-HPLC) method for the determination of Trientine hydrochloride in pharmaceutical dosage form. HPLC was performed using Waters reliant C₈ column (250 mm ¡Á 4.6 mm ID, 5¦Ìm particle size ) using a mixture of Acetronitrile : Ammonium formate buffer pH 5.3 ¡À 0.05 as mobile phase. UV detection was carried out at 220 nm. The retention time of Trientine hydrochloride was found to be 12.497min. The developed method was validated as per ICH guidelines. The proposed method was found to be suitable for the quantification of the selected drug in pharmaceutical dosage form.

International Journal of ChemTech Research published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C7H11N, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Angelina published the artcileAbraham model description of the solubilising properties of the isopropyl acetate organic mono-solvent, Computed Properties of 118-90-1, the publication is Physics and Chemistry of Liquids (2022), 60(2), 312-324, database is CAplus.

Exptl. mole fraction solubilities are reported for acenaphthene, o-acetoacetanisidide, acetylsalicylic acid, anthracene, benzil, benzoic acid, benzoin, 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 4-chlorobenzoic acid, 2-chloro-5-nitrobenzoic acid, 4-chloro-3-nitrobenzoic acid, 3,4-dichlorobenzoic acid, 3,4-dimethoxybenzoic acid, 3,5-dinitrobenzoic acid, di-Ph sulfone, fluoranthene, 9-fluorenone, 2-hydroxybenzoic acid, 2-methoxybenzoic acid, 4-methoxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 2-methyl-3-nitrobenzoic acid, 3-methyl-4-nitrobenzoic acid, 4-methyl-3-nitrobenzoic acid, 4-nitrobenzoic acid, pyrene, salicylamide, 3,4,5-trimethoxybenzoic acid, and xanthene dissolved in iso-Pr acetate at 298.15 K. Results of exptl. measurements, combined with published solubility data for an addnl. 11 organic compounds, were used to derive Abraham model correlations that described the solubilising properties of the iso-Pr acetate mono-solvent. The derived Abraham model correlations back-calculate the observed exptl. data to within 0.10 log units (or less).

Physics and Chemistry of Liquids published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C7H13NO2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tie, Yaxin published the artcileDevelopment and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market, Formula: C16H20N2, the publication is Talanta (2019), 876-887, database is CAplus and MEDLINE.

Estimations, made by the World Health Organization (WHO), state that 10% of the medical products in low- and middle-income countries are substandard or falsified (SF). Among them, antibiotics and antimalarials are the most commonly reported since 2013. Besides the fact that falsification is a crime, the worldwide use of poor quality antimicrobials could result in treatment failures, stronger antimicrobial resistance and even the promotion of the emergence of superbugs. Therefore, simple and accurate anal. methods are necessary, which are capable to detect and quantify a wide range of antimicrobials in suspected illegal products. In this work, a screening and a quantification method using ultra-high performance liquid chromatog. with tandem mass spectrometry (UHPLC-MS²) and diode array detection (UHPLC-DAD), resp. were developed and validated. These methods could be used for routine anal. and enable a more in-depth characterization of SF-antimicrobials. According to their popularity as SF-antimicrobials, 31 antibiotics, 3 antibacterial agents, 1 antifungal agent and 1 ¦Â-lactamase inhibitor, covering eleven different antibacterial classes, were selected. The UHPLC-MS² screening method with gradient elution is able to selectively detect these 36 compounds within 18 min (including wash and equilibration step). It was validated for sensitivity, selectivity and matrix effects. Within an anal. time of 32 min, the UHPLC-DAD method could quantify 32 compounds (4 showed insufficient UV absorbance) and resulted in sufficient selectivity, necessary since some SF-antimicrobials may include more than one antimicrobial component. This quantification method was validated for the pos. hits found during screening tests of suspected illegal samples. This resulted in a validation set of 11 antimicrobials and 1 ¦Â-lactamase inhibitor. The ”total error” approach in accordance with the validation requirements of ISO-17025 was employed for the validation. 57 real-life illegal samples, seized by inspectors from the Belgium Federal Agency for Medicinal and Health Products (FAMHP), were analyzed using the two described methods. About half of them were not compliant and some samples that contained clavulanic acid showed a serious reduction in the amount of this mol. (in one sample only 14% of the claimed dosage was found). These quality issues might be attributed to either poor manufacturing, storage or transportation conditions.

Talanta published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H16OSi, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yakati, Venu published the artcileEnhancing the anticancer effect of paclitaxel by using polymeric nanoparticles decorated with colorectal cancer targeting CPKSNNGVC-peptide, Safety of Fmoc-Pro-OH, the publication is Journal of Drug Delivery Science and Technology (2022), 103125, database is CAplus.

The major disadvantage of cancer chemotherapy is its lack of specificity. In recent years, selective delivery of chemotherapeutic agents to tumor sites has evolved rapidly in the form of both diagnostic and therapeutic tools in combating cancer. Herein, we develop a new polymeric nanoparticle delivery system that targets both monocarboxylate transporter 1 (MCT1) receptor-pos. cancer cells and angiogenic endothelial cells using a tumor homing peptide (CPKSNNGVC, CPK in short) as a nanoparticle surface-bound targeting ligand. By using an emulsion-solvent evaporation method, multipotent drug paclitaxel (PTX)-encapsulated poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (diameter of 215 ¡À 4 nm; zeta potential of -12 ¡À 3 mV; 16-17.5% weight/weight PTX) were synthesized. CPK peptide was thereafter conjugated to the surface of nanoparticles via maleimide-thiol chem. (CPK-PTX-NPs). Importantly, the highly stable CPK-PTX-NPs exhibited MCT1 receptor-mediated cellular uptake and apoptosis-mediated cell death in MCT1 receptor-overexpressing colorectal cancer (CRC) cells, while the other nontargeting nanoparticles failed to show MCT1 receptor-mediated cellular uptake. Remarkably, the targeted CPK-PTX-NPs selectively inhibited the formation of new blood vessels from pre-existing blood vessels (angiogenesis) in a chick embryo angiogenesis assay. In conclusion, our findings show that MCT1 receptor-selective, PTX-encapsulated and CPK peptide-decorated polymeric nanoparticles act as effective carriers for CRC-specific delivery of antineoplastic drugs to ensure significantly enhanced therapeutic efficacy.

Journal of Drug Delivery Science and Technology published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C3H12Cl2N2, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Teeter, T. E. published the artcileReduction of carbon dioxide on mercury cathodes, Synthetic Route of 17351-62-1, the publication is Proc. 6th Meeting Intern. Comm. Electrochem. Thermodynam. and Kinet. (1955), 538-42, database is CAplus.

cf. C.A. 48, 10451g. A summary of polarographic work on solutions of CO₂ in quaternary ammonium salts, of cathodic polarization experiments with solutions of KCl, NH₄Cl, NaHCO₃, N(CH₃)₄Br, etc., through which CO₂ was continuously bubbled, and of electrolysis experiments showing that HCOOH was the chief product of CO₂ reduction on Hg cathodes. Current efficiencies of HCOOH production were as follows (all solutions 0.1M): KCl 99.8; KBr 99.9; KI 99.2; NaHCO₃ 99; N(CH₃)₄HCO₃ 100; N(C₂H₅)₄HCO₃ 97; N(C₃H₇)₄HCO₃ 85; N(C₄H₈)₄HCO₃ 78%. The HCO_3- was found to be unreducible, while CO₂ was either directly reduced or reduced by amalgams or H formed in primary cathodic processes.

Proc. 6th Meeting Intern. Comm. Electrochem. Thermodynam. and Kinet. published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C11H8F2, Synthetic Route of 17351-62-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia