Tag: M.W=200-250

Alsharif, Meshari A. published the artcilePharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is ChemistrySelect (2020), 5(2), 498-505, database is CAplus.

A series of 3-nitro-2-phenyl-2H-chromenes I (R = 4-fluorophenyl, 2-nitrophenyl, naphthalen-1-yl, etc.; R¹ = H, 3-OMe, 4-Me; R² = 3-OMe, 4-F, 4-Cl, etc.) has been synthesized, characterized and tested for their inhibition potential and binding affinity with the CAMKIV. Among the synthesized compounds, the IC₅₀ value (50% of ATPase activity) for compounds I (R = 2-nitrophenyl, R¹ = H, R² = 4-F; R = 4-chlorophenyl, R¹ = 4-Me, R² = H) was observed as 12.22 ¡À 1.12¦ÌM and 16.10 ¡À 1.30¦ÌM resp. The fluorescence binding and dot-blot assay further complements inhibitory potential, indicating a better binding affinity. These compounds were tested against human cancerous cells (HepG2) and observed a significant inhibition of cell viability, induced apoptosis and lowered tau-phosphorylation. In cell viability studies, the IC₅₀ values for compounds I (R = 2-nitrophenyl, R¹ = H, R² = 4-F; R = 4-chlorophenyl, R¹ = 4-Me, R² = H) were 18.33 ¡À 1.12 and 26.22 ¡À 1.30¦ÌM resp. These results suggested that the compounds I (R = 2-nitrophenyl, R¹ = H, R² = 4-F; R = 4-chlorophenyl, R¹ = 4-Me, R² = H) are non-toxic to the normal cells and specifically inhibit the proliferation of cancerous cells.

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shamsipur, Mojtaba published the artcileThe synthesis of 1,4-diaza-2,3;8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione and its use in calcium-selective carbon paste electrodes, Category: catalysis-chemistry, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2001), 40(4), 303-307, database is CAplus.

A synthetic procedure was developed for the preparation of 1,4-diaza-2,3;8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione. A C paste electrode based on the new macrocyclic diamide was constructed for Ca²⁺ determination The calibration graph was linear over a wide concentration range (1.3 ¡Á 10^-6-3.2 ¡Á 10^-3 M) with a near Nernstian slope of 32 mV decade^-1. The limit of detection is 7.9 ¡Á 10^-7 M (0.032 ppm). Selectivity coefficients were tabulated and the working pH range was determined It has a fast response time of <10 s and can be used for at least 3 mo without any considerable divergence in potentials. The electrode was successfully applied to the determination of Ca²⁺ ions in a pharmaceutical preparation

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C18H22O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khosropour, Ahmad Reza published the artcileSynthesis of trans-cinnamic acids from aryl aldehydes and aryl aldehyde bisulfite adducts with malonic acid using piperazine, Category: catalysis-chemistry, the publication is Journal of Chemical Research (2005), 364-365, database is CAplus.

Piperazine as a new reagent for the condensation of aryl aldehydes and their bisulfite adducts with malonic acid are described which afford the corresponding cinnamic acids in excellent yields and short reaction times in the absence of solvents under microwave irradiation

Journal of Chemical Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Misra, Santosh K. published the artcileA dual strategy for sensing metals with a nano ‘pincer’ scavenger for in vitro diagnostics and detection of liver diseases from blood samples, Product Details of C6H20Cl2N4, the publication is Colloids and Surfaces, B: Biointerfaces (2015), 444-451, database is CAplus and MEDLINE.

This work presents a dual, non-invasive approach for the detection of elevated level of metals in patients with liver disease. A highly sensitive, small mol. ‘pincer’ scavenger was synthesized for the detection and quantification of copper in serum and systemically in vivo. For the in vitro diagnostics, the developed technique involves only a routine capillary blood sampling or venipuncture, removing the need for invasive biopsies. The organic scavenger mol. showed high specificity toward copper ions, with a detection sensitivity of 1.35 ¡Á 10^-2 ¦Ìg/L in mouse serum. Furthermore, for the systemic detection of copper in the liver, a polymeric nanopincer has been designed and studied. The small mol. scavengers were stably incorporated into polymeric micelles via its long acyl chains and polymeric micelle proved to be a stable carrier when injected into mice i.v. The organic scavenger mol. was found to be highly fluorescent and specific toward Cu²⁺ and can potentially help ameliorate diseases regarding accretion of copper in certain vital organs. The strategy and the results provide a novel, non-invasive dual nanomedicine approach for the early detection and treatment of excessive metal deposits in the human organs.

Colloids and Surfaces, B: Biointerfaces published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Product Details of C6H20Cl2N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ryan, Michael C. published the artcilePiperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones, Related Products of catalysis-chemistry, the publication is ACS Medicinal Chemistry Letters (2022), 13(4), 546-553, database is CAplus and MEDLINE.

While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-treated, 2-dihalomethylquinolinones unexpectedly afforded ring-expanded piperazine-fused benzodiazepinones I [R¹ = NO₂, F, CN; R² = H, NO₂; R³ = H, Br, 2-morpholinyl, etc.; R⁴ = Me, Bn; R⁵ = Me, cyclohexyl, Bn; Ar = Ph, 4-MeOC₆H₄, 4-FC₆H₄, etc.]. Notably, this new chemotype showed potent, submicromolar inhibition of virus-induced cell death, >7-log reduction of viral yield, and tractable structure-activity relationships across both viruses. Antiviral activity was confirmed in primary human neuronal cells. A mechanistic rationale for product formation is proposed, and key structural elements were comparatively modeled between a similarly substituted antiviral amidine and piperazinobenzodiazepinone prototypes to guide future antiviral development.

ACS Medicinal Chemistry Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Abhishek published the artcileCopper(II)-catalyzed decarboxylative cyclization for accessing biologically relevant 3-(2-furanyl)indoles from 3-cyanoacetyl indoles and cinnamic acids, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Tetrahedron (2020), 76(36), 131433, database is CAplus.

A novel and efficient route for the synthesis of 3-(2-furanyl)indoles I (R¹ = H, Me, Et; R² = H, Me; R³ = 6-Cl, 5-OMe, 5-F, etc.; R⁴ = Ph, 2-BrC₆H₄, 1-naphthyl, etc.) from readily available 3-cyanoacetyl indoles and ¦Á,¦Â-unsaturated carboxylic acids via Cu(II)-catalyzed decarboxylative, intermol. annulation is reported. In this transformation, di-tert-Bu peroxide was used as an external oxidant. This reaction underwent radical addition, decarboxylative processes, and provides a facile regioselective 3-(2-furanyl)indole derivatives in good to excellent yields.

Tetrahedron published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Benbow, John W. published the artcileAn efficient route to functionalized dienes for decalin synthesis, Formula: C15H15OP, the publication is Tetrahedron Letters (1997), 38(23), 4017-4020, database is CAplus.

Reaction of the trimethylsilyl (TMS) enol ethers, e.g. I, derived from the conjugate addition of organo-copper reagents to 3,4-dimethylcyclopentenone with di-Me dioxirane (DMDO) leads to ¦Á-hydroxy ketones with predominantly the syn-Me orientation. Exposure of these systems to methanolic lead tetraacetate (Pb(OAc)₄) delivers aldehydic esters which are homologated to the desired E-dienes, e.g. II, using Yamamoto’s allylic phosphine oxide reagent.

Tetrahedron Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Formula: C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ihara, Masataka published the artcileStereoselective total synthesis of (¡À)-3-oxosilphinene through intramolecular Diels-Alder reaction, Name: Allyldiphenylphosphine oxide, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1987), 1331-7, database is CAplus.

The angular tricyclopentanoid sesquiterpene (¡À)-3-oxosilphinene (I) was stereoselectively prepared with an intramol. Diels-Alder reaction as the key step. On heating, the (E,E)-sulfenyltriene II (R = CHMeCH₂CH₂CH:CHCH:CHSPh), derived from II (R = Br) gave only 1 stereoisomer of tricyclo[7.3.0.0^1.5]dodecene III having all 4 contiguous asym. centers with the required stereochem. The cycloadduct III was converted into the racemate of I via ring contraction.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Name: Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ihara, Masataka published the artcileHighly stereocontrolled synthesis of (¡À)-3-oxosilphinene via intramolecular Diels-Alder reaction, Name: Allyldiphenylphosphine oxide, the publication is Journal of the Chemical Society, Chemical Communications (1986), 671-2, database is CAplus.

The triquinane (¡À)-3-oxosilphinene (I), previously isolated from Dugaldia?hoopesii, was prepared in 18 steps from 3-bromo-2-methylcyclopent-2-enone. The key step was the intramol. Diels-Alder reaction of the diene II in o-C₆H₄Cl₂ at 200-220¡ã for 15 h to give 76% tricyclododecene III.

Journal of the Chemical Society, Chemical Communications published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Name: Allyldiphenylphosphine oxide.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ando, Ryoichi published the artcile3-(Arylacetylamino)-N-methylbenzamides: A Novel Class of Selective Anti-Helicobacter pylori Agents, SDS of cas: 1860-58-8, the publication is Journal of Medicinal Chemistry (2001), 44(25), 4468-4474, database is CAplus and MEDLINE.

After chem. modification preceded by the random screening of a chem. library, a novel class of selective anti-Helicobacter pylori agents was generated. Consequently, the 3-(arylacetylamino)-N-methylbenzamides, which were quite easy to prepare, showed potent inhibitory activity against Helicobacter pylori but exhibited no inhibitory activity against other sorts of bacteria and fungi, e.g., Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Bacteroides fragilis, and Candida albicans. These compounds showed potent anti-H. pylori activity under acidic conditions, whereas amoxicillin and clarithromycin decreased activity. The 3-(3-arylpropionylamino)-N-methylbenzamides, 3-(aryloxyacetylamino)-N-methylbenzamides, and (3-methylcarbamoylphenyl)carbamic acid 1-arylmethyl esters also exhibited potent anti-H. pylori activity. Finally, 2-C₁₀H₇CH₂CONHC₆H₄CONHMe-3 (BAS-118) was selected as a candidate compound for further evaluation.

Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, SDS of cas: 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia