Month: December 2022

Agadzhanyan, Ts. E. published the artcileSynthesis and transformations of polyhedric compounds. IV. Synthesis of 1,3,5-triazaadamantyl-7-amides of amino acids, Application of 1,3,5-Triazaadamantan-7-amine, the publication is Armyanskii Khimicheskii Zhurnal (1982), 35(6), 398-402, database is CAplus.

Title amides (e.g., I) of benzoic acid and acylglycines (phthalyl, benzoyl, methoxycarbonyl, ethoxycarbonyl) were prepared by the carbodiimide or mixed anhydride method. Reaction of I with N₂H₄ gave the free glycinamide. Reaction of 7-nitro-1,3,5-triazaadamantane with BzO₂COEt gave II.

Armyanskii Khimicheskii Zhurnal published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Application of 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bahrampour, Niki published the artcileThe relationship between dietary sulfur amino acids intake and severity and frequency of pain in Iranian patients with musculoskeletal pains, 2020, Synthetic Route of 63-68-3, the publication is BMC Research Notes (2022), 15(1), 13, database is CAplus and MEDLINE.

Musculoskeletal pain conditions (MPs) are a widespread public problem that can affect 13.5% to 47% of the total population. Dietary changes can have strong effects on persons health; for instance, Sulfur amino acids (SAAs) can act as a precursor of neurotransmitters, antioxidative metabolic intermediates, such as glutathione, impact inflammation, and play a role in severity and frequency of MPs. We evaluated the relationship between dietary SAAs intake with severity and frequency of pain in patients with MPs. This cross-sectional study consisted of 175 men and woman. Anthropometric measurements and pain assessments were conducted via questionnaires. Dietary data were collected using 7 days 24-h recall. ANOVA and Spearman correlation coefficients were used to examine the relationship and correlation, resp., between exposure and outcome variables. There was a significant correlation between age, weight, waist circumference (WC), waist circumference to height (WHtR), body mass index (BMI), and severity and frequency of MPs among women. There was a correlation between age and severity of pain in men. The present study highlights a pos. association between the dietary SAAs and severity of pain, even after adjusting for confounding variables.

BMC Research Notes published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Synthetic Route of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Julia, Marc published the artcileOrientation of the acid opening of acid-alcohols and substituted cyclopropanediols, Computed Properties of 15732-75-9, the publication is Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques (1967), 264(3), 330-2, database is CAplus.

The cyclopropane ring-opening procedure (CA 63, 2914c) was used to prepare a number of unsaturated branched- and straight-chain compounds containing OH and CO2H groups. BzCH2C(:CH2)CO2H was isomerized in the presence of NEt3 to BzCH:CMeCO2R(I, R = H), m. 110¡ã, which was methylated with CH2N2 to I (R = Me), b0.01 120-5¡ã. I (R = Me) treated with Corey’s reagent (C. and Chaykovsky, CA 62, 12994c) gave 5% cis-II (R = Me) and 95% trans-II (R = Me), 2,4-dinitrophenylhydrazone m. 145-7¡ã. Saponification of the mixture gave homogeneous (thin layer chromatography) trans-II (R = H), m. 146-7¡ã, the structure of which was confirmed by N.M.R. spectroscopy. Reduction of II (R = H) by KBH4 gave the OH-acid (III), m. 142-4¡ã, which was treated with 48% aqueous HBr at room temperature to give a product shown to be the branched acid trans-PhCH:CHCMe(CH2Br)CO2H (IV) by N.M.R. Reduction of IV by LiAlH4 gave trans-PhCH:CHCMe2CH2OH (V), b0.4 105-6¡ã; phenylurethane m. 108-9¡ã. Catalytic hydrogenation of V gave the corresponding saturated alc. b0.8 118-19¡ã, the structure of which was confirmed by comparison with the compound prepared from Et methylmalonate by alkylation with PhCH2CH2Br, reduction to the glycol m. 90-1¡ã, conversion to the bromohydrin and reduction with LiAlH4 to the saturated alc.; 3,5-dinitrobenzoate m. 94-5¡ã. Reduction of trans-II (R = H) with LiAlH4 gave the diol (VI), m. 99-100¡ã, which on treatment with 48% aqueous HBr gave PhCH:CHCMe (CH2Br)CH2OH (VII), converted to V by LiAlH4. Treatment of VII with Ac2O in pyridine gave the monoacetate but with AcOH and AcOK gave the diacetate, saponification of which gave the diol, PhCH:CHCH2CMe(OH)CH2OH which could also be prepared by treatment of VI with cold 3.6N H2SO4. trans-PhCH:CHCH2CMe2CO2Me, m. 103-5¡ã, prepared from PhCH:CHCH2CN by methylation with MeI in the presence of NaNH2 in PhMe and saponification of the intermediate PhCH:CHCMe2CN, was used as an N.M.R. reference. Similarly, PhCH:CHCH2CMe(OH)CO2Me was used and prepared by the action of PhCH:CHMe on Me pyruvate.

Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C11H10O3, Computed Properties of 15732-75-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cousse, Henri published the artcileSynthesis, structure and hypocholesteremic activity of a series of substituted ¦Ã-aryl-¦Ã-oxobutyric acids, Safety of 2-Methylene-4-oxo-4-phenylbutanoic acid, the publication is European Journal of Medicinal Chemistry (1987), 22(1), 45-57, database is CAplus.

4-Biphenylyl-2(or 3-)-methylene-4-oxobutyric acids, their isomers and derivatives, and some related compounds were prepared and tested for hypocholesteremic activity. Thus, reaction of 2-chlorobiphenyl with itaconic anhydride gave 4-(2-ClC₆H₄)C₆H₄COCH₂C(:CH₂)CO₂H (I). The 2-Cl group in I resulted in high hypocholesteremic activity. Also prepared by standard methods were 4-biphenylyl-4-oxo-2-methyl-2-butenoic acids, hydroxybutenolides, and their acid chloride and amide derivatives

European Journal of Medicinal Chemistry published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C11H10O3, Safety of 2-Methylene-4-oxo-4-phenylbutanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mohammadifarani, Ahmad published the artcileSynthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects, Related Products of catalysis-chemistry, the publication is Journal of Reports in Pharmaceutical Sciences (2020), 9(1), 128-135, database is CAplus.

Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ¡À 0.6 ¦ÌM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds

Journal of Reports in Pharmaceutical Sciences published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lamola, Jairus L. published the artcileEvaluation of P-bridged biaryl phosphine ligands in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions, SDS of cas: 613-33-2, the publication is RSC Advances (2021), 11(43), 26883-26891, database is CAplus and MEDLINE.

A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks was described. The rigid biaryl phosphacycles were efficient for synthesis of biaryls ArAr¹ [Ar = 3-MeC₆H₄, 2-naphthyl, 2-thienyl, etc.; Ar¹ = Ph, 2-MeC₆H₄, 2,6-di-MeC₆H₃] via palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl bromides/chlorides with phenylboronic acids. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature

RSC Advances published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, SDS of cas: 613-33-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Greenman, David L. published the artcileSubchronic toxicity of triethylenetetramine dihydrochloride in B6C3F1 mice and F344 rats, Application In Synthesis of 38260-01-4, the publication is Fundamental and Applied Toxicology (1996), 29(2), 185-93, database is CAplus and MEDLINE.

Triethylenetetramine dihydrochloride (trien-2HCl; CAS Number 38260-01-04), a chelating agent used to treat Wilson’s disease patients who are intolerant of the drug of choice, was tested for subchronic toxicity in B6C3F1 mice and F344 rats. Mice and rats received trien-2HCl in the drinking water at concentrations of 0, 120, 600, or 3000 ppm for up to 92 days. Twenty mice and 18 rats of each sex were assigned to each dose group fed either a cereal-based (NIH-31) or a purified (AIN-76A) diet, both containing nutritionally adequate levels of copper. This low copper diet resulted in Cu-deficiency symptoms, such as anemia, liver periportal cytomegaly, pancreatic atrophy and multifocal necrosis, spleen hematopoietic cell proliferation, and increased heart weight, together with undetectable levels of plasma copper in rats but not in mice. Trien-2HCl lowered plasma copper levels some-what (at 600 and 3000 ppm) in rats fed the AIN-76A diet, but did not induce the usual signs of copper deficiency. Trien-2HCl caused an increased frequency of uterine dilation at 3000 ppm in rats fed AIN-76A diet that was not noted in females fed the Cu-deficient diet. Trien-2HCl toxicity occurred only in mice in the highest dose group fed an AIN-76A diet. Increased frequencies of inflammation of the lung interstitium and liver periportal fatty infiltration were seen in both sexes, and hematopoietic cell proliferation was seen in the spleen of males. Kidney and body weights were reduced in males as was the incidence of renal cytoplasmic vacuolization. There were no signs of copper deficiency in mice exposed to trien-2HCl. The only effect of trien-2HCl in animals fed the NIH-31 diet was a reduced liver copper level in both rat sexes, noted at 3000 ppm.

Fundamental and Applied Toxicology published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Smith, Gerry A. published the artcileDesign of an indicator of intracellular free sodium concentration using fluorine-19 NMR, Category: catalysis-chemistry, the publication is Biochimica et Biophysica Acta, Molecular Cell Research (1986), 889(1), 72-83, database is CAplus and MEDLINE.

The development is described of a Na chelator with appropriate properties for an indicator of intracellular free Na concentration ([Na]_i). The new indicator, FCryp-1 (I), is a tribenzo derivative of the parent (2:2:1) cryptand structure, incorporating the same F-substituted dibenzo ¹⁹F-NMR reporter group as the free [Ca²⁺] indicator, 5FBAPTA. I has appropriate affinity for Na⁺ (K_Na = 10^1.3 M^-1) and selectivity over other intracellular cations (K_K; K_Ca; K_Mg < 10^-1 M^-1) for a [Na]_i indicator. There is a ¹⁹F-NMR chem. shift of 2.00 ppm between free I and the Na-I complex, which provides a direct read out of free [Na]. I carries 4 carboxylate groups to confer aqueous solubility, which can be esterified with acetoxymethyl groups to render the indicator membrane permeant. Experiments on pig lymphocytes loaded with I gave an indicated [Na]_i of 13.8 mM. The I structure can also be readily modified to provide fluorescent [Na]_i indicators.

Biochimica et Biophysica Acta, Molecular Cell Research published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C7H8O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wales, Steven M. published the artcileReversible Capture and Release of a Ligand Mediated by a Long-Range Relayed Polarity Switch in a Urea Oligomer, Computed Properties of 140-28-3, the publication is Journal of the American Chemical Society (2022), 144(7), 2841-2846, database is CAplus and MEDLINE.

Ethylene-bridged oligoureas characterized by a continuous, switchable chain of hydrogen bonds and carrying a binding site (an N,N’-disubstituted urea) for a hydrogen-bond-accepting ligand (a phosphine oxide) were synthesized. These oligomers show stronger ligand binding when the binding site is located at the hydrogen-bond-donating terminus than when the same binding site is at the hydrogen-bond-accepting terminus. An acidic group at the terminus remote from the binding site allows hydrogen bond polarity, and hence ligand binding ability, to be controlled remotely by a deprotonation/reprotonation cycle. Addition of base induces a remote conformational change that is relayed through up to five urea linkages, reducing the ability of the binding site to retain an intermol. association to its ligand, which is consequently released into solution Reprotonation returns the polarity of the oligomer to its original directionality, restoring the function of the remote binding site, which consequently recaptures the ligand. This is the first example of a synthetic mol. structure that relays intermol. binding information, and these “dynamic foldamer” structures are prototypes of components for chem. systems capable of controlling chem. function from a distance.

Journal of the American Chemical Society published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C21H24O8, Computed Properties of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gillespie, James E. published the artcileRegioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines, Synthetic Route of 1293990-73-4, the publication is Journal of the American Chemical Society (2021), 143(25), 9355-9360, database is CAplus and MEDLINE.

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Journal of the American Chemical Society published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Synthetic Route of 1293990-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia