Catalysis-chemistry

Rueda-Becerril, Montserrat published the artcileFluorine Transfer to Alkyl Radicals, HPLC of Formula: 1949-41-3, the publication is Journal of the American Chemical Society (2012), 134(9), 4026-4029, database is CAplus and MEDLINE.

The development of new synthetic technologies for the selective fluorination of organic compounds has increased with the escalating importance of fluorine-containing pharmaceuticals. Traditional methods potentially applicable to drug synthesis rely on the use of ionic forms of fluorine (F^– or F⁺). Radical methods, while potentially attractive as a complementary approach, are hindered by a paucity of safe sources of at. fluorine (F^¡¤). A new approach to alkyl fluorination has been developed that utilizes the reagent N-fluorobenzenesulfonimide as a fluorine transfer agent to alkyl radicals. This approach is successful for a broad range of alkyl radicals, including primary, secondary, tertiary, benzylic, and heteroatom-stabilized radicals. Furthermore, calculations reveal that fluorine-containing ionic reagents are likely candidates for further expansion of this approach to polar reaction media. The use of these reagents in alkyl radical fluorination has the potential to enable powerful new transformations that otherwise would take multiple synthetic steps.

Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, HPLC of Formula: 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Secula, Aurelie published the artcileMaternal dietary methionine restriction alters the expression of energy metabolism genes in the duckling liver, COA of Formula: C5H11NO2S, the publication is BMC Genomics (2022), 23(1), 407, database is CAplus and MEDLINE.

In mammals, the nutritional status experienced during embryonic development shapes key metabolic pathways and influences the health and phenotype of the future individual, a phenomenon known as nutritional programming. In farmed birds as well, the quantity and quality of feed offered to the dam can impact the phenotype of the offspring. We have previously reported that a 38% reduction in the intake of the Me donor methionine in the diet of 30 female ducks during the growing and laying periods – from 10 to 51 wk of age – reduced the body weight of their 180 mule ducklings compared to that of 190 ducklings from 30 control females. The maternal dietary methionine restriction also altered the hepatic energy metabolism studied in 30 of their ducklings. Thus, their plasma glucose and triglyceride concentrations were higher while their plasma free fatty acid level was lower than those measured in the plasma of 30 ducklings from the control group. The objective of this new study was to better understand how maternal dietary methionine restriction affected the livers of their newly hatched male and female ducklings by investigating the hepatic expression levels of 100 genes primarily targeting energy metabolism, amino acid transport, oxidative stress, apoptotic activity and susceptibility to liver injury. Sixteen of the genes studied were differentially expressed between the ducklings from the two groups. Maternal dietary methionine restriction affected the mRNA levels of genes involved in different pathways related to energy metabolism such as glycolysis, lipogenesis or electron transport. Moreover, the mRNA levels of the nuclear receptors PPARGC1B, PPARG and RXRA were also affected. Our results show that the 38% reduction in methionine intake in the diet of female ducks during the growing and egg-laying periods impacted the liver transcriptome of their offspring, which may explain the previously observed differences in their liver energy metabolism These changes in mRNA levels, together with the observed phenotypic data, suggest an early modulation in the establishment of metabolic pathways.

BMC Genomics published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C16H10O5, COA of Formula: C5H11NO2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Jia published the artcilePerforming multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Lab on a Chip (2017), 17(24), 4342-4355, database is CAplus and MEDLINE.

Despite the increasing importance of positron emission tomog. (PET) imaging in research and clin. management of disease, access to myriad new radioactive tracers is severely limited due to their short half-lives (which requires daily production) and the high cost and complexity of tracer production The application of droplet microfluidics based on electrowetting-on-dielec. (EWOD) to the field of radiochem. can significantly reduce the amount of radiation shielding necessary for safety and the amount of precursor and other reagents needed for the synthesis. Furthermore, significant improvements in the molar activity of the tracers have been observed However, widespread use of this technol. is currently hindered in part by the high cost of prototype chips and the operating complexity. To address these issues, we developed a novel microfluidic device based on patterned wettability for multi-step radiochem. reactions in microliter droplets and implemented automated systems for reagent loading and collection of the crude product after synthesis. In this paper, we describe a simple and inexpensive method for fabricating the chips, demonstrate the feasibility of prototype chips for performing multi-step radiochem. reactions to produce the PET tracers [¹⁸F]fallypride and [¹⁸F]FDG, and further show that synthesized [¹⁸F]fallypride can be used for in vivo mouse imaging.

Lab on a Chip published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C8H14O4, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Su published the artcileModular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity, Related Products of catalysis-chemistry, the publication is ChemBioChem (2021), 22(22), 3164-3168, database is CAplus and MEDLINE.

The rational design of materials with cell-selective membrane activity is an effective strategy for the development of targeted mol. imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme-mediated mol. transformation followed by supramol. assembly to form nanofibers in which cationic clusters are presented on a rigid ¦Â-sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self-assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramol. nanomaterials with emerging membrane activity for a range of disease targeted mol. imaging and therapy applications.

ChemBioChem published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C15H14O, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nasier, Abudulajiang published the artcileElectrodimerization of N-Alkoxyamides for the Synthesis of Hydrazines, SDS of cas: 6084-58-8, the publication is Journal of Organic Chemistry (2021), 86(22), 16068-16076, database is CAplus and MEDLINE.

An efficient and valuable N-N dimerization reaction of N-alkoxyamides R¹C(O)NHOR² (R¹ = Ph, 2-naphthyl, 2-furyl, etc.; R² = Me, i-Pr, Bn, etc.) is reported under undivided electrolytic conditions. This electrochem. strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines R¹C(O)N(OR²)N(OR²)C(O)R¹. Remarkably, an N-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, various N-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.

Journal of Organic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, SDS of cas: 6084-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hohn, Michael published the artcileSynthesis and Preliminary In Vitro and In Vivo Evaluation of Thiirane-Based Slow-Binding MMP Inhibitors as Potential Radiotracers for PET Imaging, Category: catalysis-chemistry, the publication is ChemistrySelect (2018), 3(42), 11729-11736, database is CAplus.

Many serious diseases such as cancer, atherosclerosis and arthritis are characterized by upregulation of activated matrix metalloproteinases (MMPs). For this reason imaging and quantification of activated MMPs with the mol. imaging techniques such as single photon emission computed tomog. (SPECT) and positron emission tomog. (PET) using radiolabeled MMP inhibitors would be a valuable tool for the diagnosis and therapy planning of mentioned diseases. This work aims at the synthesis and preliminary in vitro and in vivo evaluation of positron-emitter 18F-fluorine labeled radiotracers based on 2-{[(4-phenoxyphenyl)sulfonyl]methyl}thiirane (SB-3CT), a slow-binding and mechanism-based MMP-2 and -9 inhibitor. Therefore, a library of fluorinated SB-3CT derivatives were prepared and evaluated in vitro in MMP inhibition assays. From this pool the 18F-labeled triazole [18F]18d was successfully synthesized in a two-step procedure. However, this compound was unstable in human and mouse serum and showed a biodistribution behavior in C57BL/6 mice that is not favorable for PET imaging preventing further in vivo evaluations in MMP-associated mouse models of disease.

ChemistrySelect published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Guan-Ping published the artcileSynergistic effect of amino-functionalized SBA-15 in Cu-catalyzed oxidative homocoupling of phenylacetylene, Computed Properties of 13822-56-5, the publication is Applied Catalysis, A: General (2022), 118570, database is CAplus.

SBA-15 mesoporous silica materials with short mesochannels functionalized with various amino-groups, including NH₂-, MeNH-, diamine-, triamine- and guanidine-groups were prepared through one-pot co-condensation of tetraethylorthosilicate (TEOS) and amino-containing trimethoxysilanes in the presence of P123 as pore-directing agent and an appropriate amount of Zr(IV) ions. The resultant materials immobilized with CuCl were examined as reusable catalysts in the oxidative homocoupling of phenylacetylene at room temperature with air as the oxidant. Efforts were made to avoid the liquid base additives. The Cu-guanidine-SBA-15 catalyst with Cu/guanidine molar ratio of 0.6 was found to satisfy this objective and gave the highest yield (up to ca. 97%) and nearly 100% selectivity of 1,4-diphenyl-1,3-butadiyne in 24 h. Moreover, the catalyst could retain around 90% yield after reuses for three times.

Applied Catalysis, A: General published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Computed Properties of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lin, Pei-Min published the artcileBimetallic Nickel Complexes that Bear Diamine-Bis(Benzotriazole Phenolate) Derivatives as Efficient Catalysts for the Copolymerization of Carbon Dioxide with Epoxides, Related Products of catalysis-chemistry, the publication is ChemCatChem (2016), 8(5), 984-991, database is CAplus.

We report the facile synthesis and structural characterization of efficient bimetallic nickel catalysts that bear diamine-bis(benzotriazole phenolate) derivatives for the copolymerization of CO₂ and epoxides. Thermally robust di-nickel 2 is an effective catalyst for the alternating copolymerization of cyclohexene oxide (CHO) with CO₂ to give turnover numbers of up to >4000 and turnover frequencies of up to >400 h^-1. Ni catalyst 2 leads to not only controlled CO₂/CHO coupling, but it has also been applied to catalyze the copolymerization of 4-vinyl-1,2-cyclohexene oxide (VCHO) and CO₂ to obtain the corresponding polycarbonate with the vinyl functionality on the side chains. This is the first example of a dinuclear Ni complex that is efficient for both CO₂/VCHO copolymerization and the formation of a high-mol.-weight copolymer with a large amount of carbonate linkages.

ChemCatChem published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Senthamarai, Thirusangumurugan published the artcileA “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides, COA of Formula: C8H8O2, the publication is Chem (2022), 8(2), 508-531, database is CAplus.

Here, the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst was reported. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcs. in excellent yields in the presence of air.

Chem published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H9F5Si, COA of Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Swamy, K. C. Kumara published the artcilePentacoordinated molecules. 79. Pentacoordinate acyclic and cyclic anionic oxysilicates. A silicon-29 NMR and x-ray structural study, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of the American Chemical Society (1990), 112(6), 2341-8, database is CAplus.

Variable temperature ²⁹Si NMR spectral measurements revealed the formation of acyclic anionic silicates, [R_n‘Si(OR)_5-n][K,18-crown-6], n = 0-3, from reactions of alkoxy and aryloxysilanes with the resp. potassium alkoxide or potassium aryloxide in the presence of 18-crown-6. This elusive class of substances has been proposed as model intermediates in the sol-gel process. In the case of [PhSi(OCH₂CF₃)₄][K,18-crown-6], isolation as a crystalline solid was achieved. The ²⁹Si chem. shifts move progressively downfield from Si(OR)₅^– to R’Si(OR)₄^– to R₂‘Si(OR)₃^–. Pentaalkoxysilicate anions react rapidly with pinacol to form the corresponding five-coordinated bicyclic anionic silicate. Independent synthesis and an x-ray structural study verified the formation of the bis(pinacolate) [(OCMe₂CMe₂O)₂SiOCHMe₂][K,18-crown-6] (I). For comparison of structural distortions, the synthetic and x-ray characterization of the related anionic oxysilicates [(C₆H₄(CF₃)₂CO)₂SiR][Et₄N] (II) and [(C₆H₄O₂)₂SiR][Me₂NH₂] (III) (R = cyclohexyl) are reported. The structures of I and II are trigonal-bipyramidal and that of III is rectangular-pyramidal.

Journal of the American Chemical Society published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C9H9F5Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia