Catalysis-chemistry

Verma, Sanjeev K. published the artcileImidazole-Catalyzed Monoacylation of Symmetrical Diamines, Computed Properties of 10517-44-9, the publication is Organic Letters (2010), 12(19), 4232-4235, database is CAplus and MEDLINE.

An imidazole-catalyzed protocol for monoacylation of sym. diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.

Organic Letters published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C11H19N, Computed Properties of 10517-44-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abd El-Wahab, Hend A. A. published the artcileDesign, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics, Product Details of C16H20N2, the publication is Bioorganic & Medicinal Chemistry (2018), 26(1), 161-176, database is CAplus and MEDLINE.

Three series of azole piperazine derivatives that mimic dicyclotyrosine (cYY), the natural substrate of the essential Mycobacterium tuberculosis cytochrome P 450 CYP121A1, were prepared and evaluated for binding affinity and inhibitory activity (MIC) against M. tuberculosis. Series A replaces one phenol group of cYY with a C3-imidazole moiety, series B includes a keto group on the hydrocarbon chain preceding the series A imidazole, while series C explores replacing the keto group of the piperidone ring of cYY with a CH₂-imidazole or CH₂-triazole moiety to enhance binding interaction with the heme of CYP121A1. The series displayed moderate to weak type II binding affinity for CYP121A1, with the exception of series B 10a, which displayed mixed type I binding. Of the three series, series C imidazole derivatives showed the best, although modest, inhibitory activity against M. tuberculosis (17d MIC = 12.5 μg/mL, 17a 50 μg/mL). Crystal structures were determined for CYP121A1 bound to series A compounds 6a and 6b that show the imidazole groups positioned directly above the haem iron with binding between the haem iron and imidazole nitrogen of both compounds at a distance of 2.2 Å. A model generated from a 1.5 Å crystal structure of CYP121A1 in complex with compound 10a showed different binding modes in agreement with the heterogeneous binding observed Although the crystal structures of 6a and 6b would indicate binding with CYP121A1, the binding assays themselves did not allow confirmation of CYP121A1 as the target.

Bioorganic & Medicinal Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Product Details of C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hassan, Hishar published the artcileImproving the ¹⁸F-fluoromethylcholine (¹⁸F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added ¹⁸F-fluorine, Related Products of catalysis-chemistry, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2015), 58(11-12), 458-459, database is CAplus and MEDLINE.

¹⁸F-Fluoromethylcholine (¹⁸F-FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumor in PET/CT examination Nevertheless, it has never been synthesized in Malaysia. The authors acknowledge that the major problem with ¹⁸F-FCH is due to its relatively low radiochem. yield at the end of synthesis (EOS). Therefore, this tech. note presents improved ¹⁸F-FCH radiochem. yields after carrying out optimization on azeotropic drying of non-carrier-added ¹⁸F-fluorine.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gad, Nourhan M. published the artcileReactivity of 5-phenyl-3-[(2-chloroquinolin-3-yl)methylene]furan-2(3H)-one towards hydrazine and benzylamine: A comparative study, Application In Synthesis of 2051-95-8, the publication is Synthetic Communications (2021), 51(9), 1384-1397, database is CAplus.

The reactivity of a 2-chloroquinolinylfuranone derivative was investigated against two nitrogen nucleophilic reagents namely, hydrazine and benzylamine. It was found that the regioselectivity of the reaction products was mainly dependent on the nature of nucleophiles, reaction conditions and solvent used. Therefore, hydrazinolysis of afforded the corresponding acid hydrazide and pyridazinone derivatives depending on the reaction conditions. Otherwise, benzylamine reacted with at different reaction aspects to provide N-benzylamide, N-benzylpyrrolone, and 2-benzylaminoquinolinyl-N-benzylpyrrolone derivatives The chem. structures of all synthesized compounds were substantiated from their anal. as well as spectroscopic data. Based on the charge d. calculations and computational chem. study which excluded the aza-Michael addition reaction and confirm the higher electron-deficiency of lactone carbonyl group than C2-quinoline position, it could be concluded that the C2-furanone becomes more susceptible to attack by the nucleophilic reagent, hydrazine and benzylamine.

Synthetic Communications published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Application In Synthesis of 2051-95-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reisner, Erwin published the artcileInfluence of Steric Hindrance on the Core Geometry and Sulfoxidation Chemistry of Carboxylate-rich Diiron(II) Complexes, Application In Synthesis of 22693-41-0, the publication is Inorganic Chemistry (2007), 46(24), 10229-10240, database is CAplus and MEDLINE.

The asym. terphenyl-2′-carboxylate ligand 3,5-dimethyl-1,1′:3′,1”-terphenyl-2′-carboxylate, ^–O₂CAr^Ph,Xyl, was prepared in high yield. This ligand facilitates the assembly of the diiron(II) complexes [Fe₂(μ-O₂CAr^Tol)₂(O₂CAr^Ph,Xyl)₂(THF)₂] [2, ^–O₂CAr^Tol = 2,6-di-p-tolylbenzoate], [Fe₂(μ-O₂CAr^Tol)₂(O₂CAr^Ph,Xyl)₂(pyridine)₂] (5), [Fe₂(μ-O₂CAr^Ph,Xyl)₂(O₂CAr^Ph,Xyl)₂(THF)₂] (3), and [Fe₂(μ-O₂CAr^Ph,Xyl)₂(O₂CAr^Ph,Xyl)₂(pyridine)₂] (6), all of which have a windmill geometry. The Fe-Fe distance of 3.355[10] Å in 6 is âˆ? Å shorter than that in the analog [Fe₂(μ-O₂CAr^Tol)₂(O₂CAr^Tol)₂(pyridine)₂] (4) and similar to the âˆ?.3 Å metal-metal separation at the active site of the reduced diiron(II) form of the soluble methane monooxygenase hydroxylase enzyme (MMOH_red). Ortho-substituted picolyl-based ligands, 2-picSMe, 2-picSEt, 2-picS^tBu, 2-picSPh, 2-picSPh(Me₃) (Ph(Me₃) = mesityl), and 2-picSPh(ⁱPr₃) (Ph(ⁱPr₃) = 2,4,6-triisopropylphenyl), were prepared and allowed to react with [Fe₂(μ-O₂CAr)₂(O₂CAr)₂(THF)₂] to produce [Fe₂(μ-O₂CAr)₃(O₂CAr)(picSR)] (7–13, Ar = Ar^Tol or Ar^Ph,Xyl) complexes in 45-87% yields. The substrates tethered to the pyridine N-donor ligands picSR, where R = Me, Et, ^tBu, or Ph, coordinate to one Fe atom of the diiron(II) center by the N and S atoms to form a five-membered chelate ring. The Fe-S distance becomes elongated with increasing steric hindrance imparted by the R group. The most sterically hindered ligands, 2-picSPh(Me₃) and 2-picSPh(ⁱPr₃), bind to the metal only through the pyridine N atom. The reactions of several of these complexes with dioxygen were studied, and the oxygenated products were analyzed by ¹H NMR spectroscopy and GC/MS measurements following decomposition on a Chelex resin. The amount of sulfoxidation product is correlated with the Fe···S distance. The ratio of oxidized to unoxidized thioether substrate varies from 3.5, obtained upon oxygenation of the weakly coordinated 2-picSPh ligand in 10, to 1.0, obtained for the bulky 2-picSPh(ⁱPr₃) ligand in 12, for which the Fe-S distance is >4 Å. External thioether substrates were not oxidized when present in oxygenated solutions of paddlewheel and windmill diiron(II) complexes containing 1-methylimidazole or pyridine ligands, resp.

Inorganic Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Application In Synthesis of 22693-41-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sismondi, A. published the artcileSynthesis of novel intermediate fluoroalkyl precursors to highly fluorinated cationic surfactants, Category: catalysis-chemistry, the publication is Journal of Fluorine Chemistry (1992), 59(1), 127-32, database is CAplus.

The syntheses of F-alkyl compounds such as R_FC₂H₄ZCOCH₂Br (R_F = C₄F₉, C₆F₁₃, C₈F₁₇; Z = S, O, NH) by the reaction of bromoacetyl bromide with an F-alkyl compound such as R_FC₂H₄ZH are reported. These compounds show high reactivity with nucleophilic substrates, e.g., Et₃N. They are intended for use as precursors of surfactants or as precursors of monomers for the elaboration of artificial vesicles.

Journal of Fluorine Chemistry published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C13H10O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sareen, Divya published the artcileHost-guest complexation behavior of emissive calix[3]naphthobipyrrole toward aromatic guests, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Supramolecular Chemistry (2018), 30(11), 949-954, database is CAplus.

A new hexapyrrolic macrocycle composed of three naphthobipyrrole units has been synthesized which exhibited different emission changes with hydrogen pyrophosphate and benzoate ions. Phosphate ions caused red shifting of the fluorescence band of calixnaphthobipyrrole while benzoate ions resulted in quenching of the same. The fluorescence quenching was further utilized for investigating binding preferences of the probe with neutral aromatic guest mols. substituted with groups having varied electron withdrawing abilities. The extent of quenching with the neutral guests increased with the increasing electron deficiency on the aromatic ring of the guest. The fluorescence quenching has been ascribed to electron transfer from the host to the guest species.

Supramolecular Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Recommanded Product: Tetrabutylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abdelbaset, Mahmoud S. published the artcileDesign, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors, Related Products of catalysis-chemistry, the publication is Bioorganic Chemistry (2021), 104522, database is CAplus and MEDLINE.

A potential microtubule destabilizing series of new thirty-five Pyrrol-2-one, Pyridazin-3(2H)-one and Pyridazin-3(2H)-one/oxime derivatives has been synthesized and tested for their antiproliferative activity against a panel of 60 human cancer cell lines. Compounds IVc, IVg and IVf showed a broad spectrum of growth inhibitory activity against cancer cell lines representing renal, cancer of lung, colon, central nervous system, ovary, and kidney. Among them, compound IVg was found to have broad spectrum anti-tumor activity against the tested nine tumor subpanels with selectivity ratios ranging between 0.21 and 3.77 at the GI50 level. In vitro assaying revealed tubulin polymerization inhibition by all active compounds IVc, IVg and IVf. The results of the docking study revealed nice fitting of compounds IVc, IVf, and IVg into CA-4 binding site in tubulin. The three compounds exhibited high binding affinities (ΔGb = -12.49 to -12.99 kcal/mol) toward tubulin compared to CA-4 (-8.87 kcal/mol). Investigation of the binding modes of the three compounds IVc, IVf, and IVg revealed that they interacted mainly hydrophobically with tubulin and similar binding orientations to that of CA-4. These observations suggest that tubulin is a possible target for these compounds

Bioorganic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gharagheizi, Farhad published the artcileA New Neural Network Group Contribution Method for Estimation of Upper Flash Point of Pure Chemicals, COA of Formula: C12H9N3O4, the publication is Industrial & Engineering Chemistry Research (2010), 49(24), 12685-12695, database is CAplus.

A new group contribution-based models is presented to predict the upper flash point temperature of pure compounds based on a large dataset (1294). This neural network model uses several occurrences of 122 chem. groups in a pure compound to predict its related upper flash point limit. The model squared correlation coefficient, average percent error, mean average error, and root-mean-square error over the main dataset (1294 pure compounds) were 0.99, 1.7%, 6, and 8.5, resp.

Industrial & Engineering Chemistry Research published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, COA of Formula: C12H9N3O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fancelli, Daniele published the artcileCinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2014), 57(12), 5333-5347, database is CAplus and MEDLINE.

In this account, we report the development of a series of substituted cinnamic anilides that represents a novel class of mitochondrial permeability transition pore (mPTP) inhibitors. Initial class expansion led to the establishment of the basic structural requirements for activity and to the identification of derivatives with inhibitory potency higher than that of the standard inhibitor cyclosporine-A (CsA). These compounds can inhibit mPTP opening in response to several stimuli including calcium overload, oxidative stress, and thiol cross-linkers. The activity of the cinnamic anilide mPTP inhibitors turned out to be additive with that of CsA, suggesting for these inhibitors a mol. target different from cyclophylin-D. In vitro and in vivo data are presented for (E)-3-(4-fluoro-3-hydroxy-phenyl)-N-naphthalen-1-yl-acrylamide 22, one of the most interesting compounds in this series, able to attenuate opening of the mPTP and limit reperfusion injury in a rabbit model of acute myocardial infarction.

Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia