Catalysis-chemistry

Liu, Hechun published the artcileEffects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients, Computed Properties of 6217-54-5, the publication is Lipids in Health and Disease (2022), 21(1), 20, database is CAplus and MEDLINE.

Dietary fatty acids intake affects the composition of erythrocyte fatty acids, which is strongly correlated with glycolipid metabolism disorders. This study aimed at investigating the different effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acid (n-3 PUFA) on the fatty acids of erythrocytes and glycolipid metabolism in patients with type 2 diabetes mellitus (T2DM). The randomized double-blinded trial that was performed on 180 T2DM patients. The participants were randomly assigned to three groups for the six-month intervention. The fish oil (FO) group was administered with FO at a dose of 3 g/day containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the perilla oil (PO) group was administered with PO at a dose of 3 g/day containing ¦Á-linolenic (ALA), the linseed and fish oil (LFO) group was administered with mixed linseed and fish oil at a dose of 3 g/day containing EPA, DHA and ALA. Demog. information were collected and anthropometric indexes, glucose and lipid metabolism indexes, erythrocyte fatty acid composition were measured. Statistical analyses were performed using two-way ANOVA. A total of 150 patients finished the trial, with 52 of them in the FO group, 50 in the PO group and 48 in the LFO group. There were significant effects of time x treatment interaction on fast blood glucose (FBG), insulin, HOMA-IR and C-peptide, TC and triglyceride (TG) levels (P < 0.001). Glucose and C-peptide in PO and LFO groups decreased significantly and serum TG in FO group significantly decreased (P < 0.001) after the intervention. Erythrocyte C22: 5 n-6, ALA, DPA, n-6/n-3 PUFA, AA/EPA levels in the PO group were significantly higher than FO and LFO groups, while EPA, total n-3 PUFA and Omega-3 index were significantly higher in the FO and LFO groups compared to PO group. Supplementation with perilla oil decreased FBG while fish oil supplementation decreased the TG level. Marine-based and plant-based n-3 PUFAs exhibit different effects on fatty acid compositions of erythrocytes and regulated glycolipid metabolism This trial was recorded under Chinese Clin. Trial Registry Center (NO: ChiCTR-IOR-16008435) on May 28 2016.

Lipids in Health and Disease published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Computed Properties of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Xin-yang published the artcileDiscovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis, Formula: C8H8O2, the publication is Bioorganic Chemistry (2022), 105469, database is CAplus and MEDLINE.

Targeting EGFR and HER-2 is an essential direction for cancer treatment. Here, a series of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure was designed and synthesized to serve as EGFR/HER-2 dual-target inhibitors. The kinase assays verified that target compounds could inhibit the kinase activity of EGFR and HER-2 selectively. The results of CCK-8 and 3D cell viability assays confirmed that target compounds had excellent anti-proliferation ability against breast cancer cells (MCF-7 and SK-BR-3) and lung cancer cells (A549 and H1975), particularly against SK-BR-3 cells, while the inhibitory effect on healthy breast cells (MCF-10A) and lung cells (Beas-2B) was weak. Among them, the hit compound YH-9 binded to EGFR and HER-2 stably in mol. dynamics studies. Further studies found that YH-9 could induce the release of cytochrome c and inhibit proliferation by promoting ROS expression in SK-BR-3 cells. Moreover, YH-9 could diminish the secretion of VEGF and bFGF factors in SK-BR-3 cells, then inhibited tube formation and angiogenesis. Notably, YH-9 could effectively inhibit breast cancer growth and angiogenesis with little toxicity in the SK-BR-3 cell xenograft model. Taken together, in vitro and in vivo results revealed that YH-9 had high drug potential as a dual-target inhibitor of EGFR/HER-2 to inhibit breast cancer growth and angiogenesis.

Bioorganic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Di-Zao published the artcileSynthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors, Related Products of catalysis-chemistry, the publication is Journal of Asian Natural Products Research (2013), 15(11), 1179-1188, database is CAplus and MEDLINE.

In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series of novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on a synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid ester derivatives Most of the derivatives were assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, and A2780, and most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines especially on KB.

Journal of Asian Natural Products Research published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Chuang-Chuang published the artcileSynthetic Study of 1,3-Butadiene-Based IMDA Approach to Construct a [5-7-6] Tricyclic Core and Its Application to the Total Synthesis of C8-epi-Guanacastepene O, Computed Properties of 4141-48-4, the publication is Journal of Organic Chemistry (2006), 71(18), 6892-6897, database is CAplus and MEDLINE.

An efficient intramol. Diels-Alder (IMDA) strategy for the construction of the [5-7-6] tricyclic core I of guanacastepenes has been developed from cis- and trans-1,3-butadiene-tethered 4-oxopent-2-ynoic acid Et esters II and III. This method facilitates the synthesis of C8-epi-guanacastepene O IV in a very efficient manner.

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Computed Properties of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Teo, Wei Jie published the artcileCobalt-Catalyzed Z-Selective Hydrosilylation of Terminal Alkynes, Formula: C9H5F3O, the publication is Angewandte Chemie, International Edition (2017), 56(15), 4328-4332, database is CAplus and MEDLINE.

A cobalt-catalyzed Z-selective hydrosilylation of alkynes has been developed relying on catalysts generated from bench-stable Co(OAc)₂ and pyridine-2,6-diimine (PDI) ligands. A variety of functionalized aromatic and aliphatic alkynes undergo this transformation, yielding Z-vinylsilanes in high yields with excellent selectivities (Z/E ratio ranges from 90:10 to >99:1). The addition of a catalytic amount of phenol effectively suppressed the Z/E-isomerization of the Z-vinylsilanes that formed under catalytic conditions.

Angewandte Chemie, International Edition published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C8H11NO, Formula: C9H5F3O.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fu, Shengli published the artcileEffects of faba bean (Vicia faba) diet on amino acid and fatty acid composition, flesh quality and expression of muscle quality-related genes in muscle of “crispy” grass carp, Ctenopharyngodon idella, Product Details of C22H32O2, the publication is Aquaculture Research (2022), 53(13), 4653-4662, database is CAplus.

Faba bean meal (FBM) was used to replace protein materials in different proportions, and its impacts on amino acid and fatty acid composition, flesh quality and expression of muscle quality-related genes in muscle of grass carp (Ctenopharyngodon idella) were evaluated. In the breeding process of crispy grass carp, the addition of FB is very high, which has adverse effects on the physiol. function of grass carp. In order to determine the optimum addition amount of FB in crispy grass carp culture, five isonitrogenous (approx. 33.79% crude protein, CP) and isolipidic (approx. 3.43% crude lipid) diets containing different levels of FBM replacing protein materials 0% (CON), 70% (FBM70), 80% (FBM80), 90% (FBM90) and 100% (FBM100) were formulated and were randomly assigned to triplicate groups of fish for 100 days. The results showed that FBM supplement significantly enhanced the myofiber area and radius, content of collagen and CP in muscle. Moreover, compared with the CON group, the content of inosine 5¡ä-monphosphate (IMP), total amino acid (TAA), total non-essential amino acid (TNAA) and the expression of collagen-related (collagen type 1 alpha 1 chain [col1a1] and collagen type 1 alpha 2 chain [col1a2]) and muscle quality-related genes (fibroblast growth factor 6a [fgf6aI] and fibroblast growth factor 6b [fgf6b]) was the highest in the FBM70 group and the lowest in the FBM100 group. In conclusion, the maximal proportion of dietary protein replacement with FBM was 70% based on the flesh quality of grass carp, which provided guidance for the cultivation of crisp grass carp.

Aquaculture Research published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Product Details of C22H32O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tierno, Anthony F. published the artcileHeterocyclic group transfer reactions with I(III) N-HVI reagents: access to N-alkyl(heteroaryl)onium salts via olefin aminolactonization, COA of Formula: C10H10O3, the publication is Chemical Science (2021), 12(18), 6385-6392, database is CAplus and MEDLINE.

Herein, leverage (bis)cationic nitrogen-ligated I(III) hypervalent iodine reagents, or N-HVIs, as “heterocyclic group transfer reagents” to provide access to a broad scope of N-alkyl(heteroaryl)onium salts e.g., I via the aminolactonization of alkenoic acids e.g., 2,2-diphenylpent-4-enoic acid, the first example of engaging an olefin to directly generate these salts. The reactions proceed in excellent yields, under mild conditions, and are capable of incorporating a broad scope of sterically and electronically diverse aromatic heterocycles such as pyridine, 4-piperidinylpyridine, 1-methylimidazole, etc.. The N-HVI reagents can be generated in situ, the products are isolated via simple trituration, and subsequent derivatizations demonstrate the power of this platform for diversity-oriented synthesis of 6-membered nitrogen heterocycles e.g., I.

Chemical Science published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C38H24F4O4P2, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Santavy, Frantisek published the artcileUltraviolet spectra of the methoxy and methylenedioxy groups of some aromatic compounds and alkaloids. IV. Effect of hydroxyl, methoxyl, and methylenedioxy groups on ultraviolet spectra of aromatic compounds conjugated with an oxo group or with an ¦Á,¦Â-double bond in the side chain, Category: catalysis-chemistry, the publication is Collection of Czechoslovak Chemical Communications (1972), 37(6), 1825-50, database is CAplus.

Uv spectra of hydroxy, methoxy, and methylenedioxy derivatives of C6H6, PhCHO, BzOH, MeBz, EtBz, 1-indanone, 1,2-indanedione, MeCH:CHPh, cis- and trans-cinnamic acids, PhCH:NOH, PhCMe:NOH, and 1-indanone oxime were measured in dioxane or EtOH or EtOH-NaOH and discussed.

Collection of Czechoslovak Chemical Communications published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gibbs, Kathleen published the artcileThe effect of certain chelating compounds on the urinary excretion of copper by the rat: observations on their clinical significance, HPLC of Formula: 38260-01-4, the publication is Clinical Science and Molecular Medicine (1977), 53(4), 317-20, database is CAplus and MEDLINE.

Basal urine Cu excretion by rats was increased from 65.1 to 367.1 or 305.9 nmol/24 h by penicillamine [52-67-5] or triethylene tetramine-2HCl [38260-01-4] (100 mg orally), resp. Certain chelating agents depressed Cu excretion, e.g. 1,2,4-triazole [288-88-0] reduced excretion to 20.6 nmol/24 h, probably by forming insoluble chelates, rendering Cu unavailable for excretion at the glomerulus. The use of this screening procedure to assess rapidly the potential of chelating agents for the treatment of Wilson’s disease is discussed.

Clinical Science and Molecular Medicine published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sayer, James R. published the artcileDesign, synthesis, and evaluation of peptide-imidazo[1,2-a]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525, Safety of Fmoc-Pro-OH, the publication is Journal of Peptide Science (2021), 27(10), e3353, database is CAplus and MEDLINE.

Helicobacter pylori (H. pylori) infections were implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathogenicity of H. pylori is mediated by the type IV secretion system (T4SS), a multiprotein macromol. nanomachine that transfers toxic bacterial factors and plasmid DNA between bacterial cells, thus contributing to the spread of antibiotic resistance. A key component of the T4SS is the VirB11 ATPase HP0525, which is a hexameric protein assembly. The authors have previously reported the design and synthesis of a series of novel 8-amino imidazo[1,2-a]pyrazine derivatives as inhibitors of HP0525. In order to improve their selectivity, and potentially develop these compounds as tools for probing the assembly of the HP0525 hexamer, the authors have explored the design and synthesis of potential bivalent inhibitors. The authors used the structural details of the subunit-subunit interactions within the HP0525 hexamer to design peptide recognition moieties of the subunit interface. Different methods (cross metathesis, click chem., and cysteine-malemide) for bioconjugation to selected 8-amino imidazo[1,2-a]pyrazines were explored, as well as peptides spanning larger or smaller regions of the interface. The IC₅₀ values of the resulting linker-8-amino imidazo[1,2-a]pyrazine derivatives, and the bivalent inhibitors, were related to docking studies with the HP0525 crystal structure and to mol. dynamics simulations of the peptide recognition moieties.

Journal of Peptide Science published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia