Catalysis-chemistry

Leibler, Isabelle Nathalie-Marie published the artcileA general strategy for C(sp³)-H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor, HPLC of Formula: 457-68-1, the publication is Nature Communications (2021), 12(1), 6950, database is CAplus and MEDLINE.

A strategy that transforms C(sp³)-H bonds into carbocations via sequential hydrogen atom transfer (HAT) and oxidative radical-polar crossover were discussed. The resulting carbocation was functionalized by a variety of nucleophiles-including halides, water, alcs., thiols, an electron-rich arene and an azide-to effect diverse bond formations. Mechanistic studies indicated that HAT was mediated by Me radical-a previously unexplored HAT agent with differing polarity to many of those used in photoredox catalysis-enabling new site-selectivity for late-stage C(sp³)-H functionalization.

Nature Communications published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, HPLC of Formula: 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Perez, Bianca C. published the artcileN-Cinnamoylated Chloroquine Analogues as Dual-Stage Antimalarial Leads, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2013), 56(2), 556-567, database is CAplus and MEDLINE.

The control of malaria is challenged by drug resistance, and new antimalarial drugs are needed. New drug discovery efforts include consideration of hybrid compounds as potential multitarget antimalarials. Previous work from our group has demonstrated that hybrid structures resulting from cinnamic acid conjugation with heterocyclic moieties from well-known antimalarials present improved antimalarial activity. Now, we report the synthesis and SAR anal. of an expanded series of cinnamic acid derivatives displaying remarkably high activities against both blood- and liver-stage malaria parasites. Two compounds judged most promising, based on their in vitro activity and druglikeness according to the Lipinski rules and Veber filter, were active in vivo against blood-stage rodent malaria parasites. Therefore, the compounds reported represent a new entry as promising dual-stage antimalarial leads.

Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fabre, C. published the artcileGem effects: basicity measurement. The doubtful nature of generalities of conformational effects of geminal disubstitution, Recommanded Product: Propane-1,3-diamine dihydrochloride, the publication is Nouveau Journal de Chimie (1980), 4(10), 609-14, database is CAplus.

Geminal disubstitution does not systematically involve a decrease in the distance between the ends of an aliphatic chain. Thus, the pK values of I (R = H, Me) are identical. On the other hand, basicity differences were observed for II (m = 1; R = H, Me); no basicity differences were observed for II (m = 2, 3; R = H, Me).

Nouveau Journal de Chimie published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Recommanded Product: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ranjbari, Mohammad A. published the artcileRegioselective and solvent-free arylation of ¦Â-nitrostyrenes with mono- and dialkyl anilines, Category: catalysis-chemistry, the publication is Research on Chemical Intermediates (2021), 47(2), 709-721, database is CAplus.

A green and solvent-free method was developed for alkylation of N,N-dialkylanilines with substituted ¦Â-nitrostyrenes using 10 mol% of choline chloride-zinc chloride deep eutectic solvent at 70¡ã. The reaction was highly regioselective and only para-substituted products have been prepared Despite the sensitivity and weak reactivity of the aniline derivatives for the Friedel-Crafts reaction in acidic media, the presented procedure was successfully carried out this transformation. The synthetic protocol was expanded for the alkylation of pyrrole and indole to produce pharmaceutically active compounds The reduction of the nitro group of the product to amine was performed using Pd/C and hydrazine to produce amphetamine structure.

Research on Chemical Intermediates published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gridunov, I. T. published the artcileStudy of the effect of adamantane derivatives in nitrile rubber vulcanizates, Related Products of catalysis-chemistry, the publication is Trudy Instituta – Moskovskii Institut Tonkoi Khimicheskoi Tekhnologii imeni M. V. Lomonosova (1975), 5(1), 97-9, database is CAplus.

The vulcanization of SKN 26 rubber in the presence of 0.6-1.4% 7-nitro-1,3,5-triazaadamantane (I) [14612-28-3], 7-amino-1,3,5-triazaadamantane (II) [14707-75-6] or 7-dimethylamino-1,3,5-triazaadamantane (III) [32476-16-7] at 150-80¡ã showed that I, II, and III were vulcanization accelerators having a large induction period. The vulcanizates had good physicomech. properties when SKN 26 rubber was vulcanized in the presence of I at 180¡ã for 50 min.

Trudy Instituta – Moskovskii Institut Tonkoi Khimicheskoi Tekhnologii imeni M. V. Lomonosova published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gridunov, I. T. published the artcileEffect of 7-amino-1,3,5-triazaadamantane on the crosslinking of butadiene-acrylonitrile rubber, Recommanded Product: 1,3,5-Triazaadamantan-7-amine, the publication is Kauchuk i Rezina (1977), 19-20, database is CAplus.

7-Amino-1,3,5-triazaadamantane (I) [14707-75-6], prepared in a 2-step process via 7-nitro-1,3,5-triazaadamantane preparation and reduction, was an effective vulcanization accelerator for nitrile rubber SKN-26. Rubber compositions containing an optimal amount of 1 phr I gave vulcanizates having improved physicomech. properties in comparison to those obtained using a standard accelerator (2-MBT). In addition I can be used at higher vulcanization temperatures (¡Ü180¡ã) than the 2-MBT.

Kauchuk i Rezina published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Recommanded Product: 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Whyte-Fagundes, Paige published the artcilePanx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling, Application of (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Communications Biology (2022), 5(1), 472, database is CAplus and MEDLINE.

The mol. mechanisms of excitation/inhibition imbalances promoting seizure generation in epilepsy patients are not fully understood. Evidence suggests that Pannexin1 (Panx1), an ATP release channel, modulates the excitability of the brain. In this report, we performed electrophysiol., behavioral, and mol. phenotyping experiments on zebrafish larvae bearing genetic or pharmacol. knockouts of Panx1a and Panx1b channels, each homologous to human PANX1. When Panx1a function is lost, or both channels are under pharmacol. blockade, seizures with ictal-like events and seizure-like locomotion are reduced in the presence of pentylenetetrazol. Transcriptome profiling by RNA-seq demonstrates a spectrum of distinct metabolic and cell signaling states which correlate with the loss of Panx1a. Furthermore, the pro- and anticonvulsant activities of both Panx1 channels affect ATP release and involve the purinergic receptor P2rx7. Our findings suggest a subfunctionalization of Panx1 enabling dual roles in seizures, providing a unique and comprehensive perspective to understanding seizure mechanisms in the context of this channel.

Communications Biology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C12H14O2, Application of (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fujito, Hiroshi published the artcileA study of efficient preparation of triethylenetetramine dihydrochloride for the treatment of Wilson’s disease and hygroscopicity of its capsule, Synthetic Route of 38260-01-4, the publication is Yakuzaigaku (1990), 50(4), 402-8, database is CAplus.

Triethylenetetramine-2HCl (I) for the treatment of Wilson’s disease is generally prepared by the reaction of triethylenetetramine (trien) and concentrated HCl. Using this method, the yield of I was 46.2% and trien-4HCl was obtained in a 21.3% yield as a byproduct. On the other hand, I was obtained in a 88.5% yield without formation of trien-4HCl by the reaction of trien and HCl gas in absolute EtOH. Capsules packed with I could stock for 30 days under 53% relative humidities of 25¡ã.

Yakuzaigaku published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sidneva, Vera V. published the artcileOne-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles containing an alkenyl moiety, Product Details of C9H7NO4, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2022), 58(6-7), 349-353, database is CAplus.

A one-pot method was developed for the preparation of 3,5-disubstituted 1,2,4-oxadiazoles containing an alkenyl fragment I (R = Ph, 3-O₂NC₆H₄, 3-pyridyl, etc.; R¹ = Ph, 3-ClC₆H₄, 2-thienyl, etc.), which entails the preparation of O-acylamidoximes and their subsequent cyclization using N,N¡ä-dimethylacetamide as a solvent. The proposed method allows to significantly reduce the overall synthesis time by carrying out all steps sequentially in a single reactor, avoiding the step of isolation of the intermediate O-acylamidoxime, leading to the production of 5-alkenyl-1,2,4-oxadiazoles in high yields.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C15H10O2, Product Details of C9H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jones, Peter G. published the artcileMethylthioureas and their morpholine and dioxane adducts; hydrogen-bonding patterns, Recommanded Product: 1,1-Dimethylthiourea, the publication is Acta Crystallographica, Section B: Structural Science, Crystal Engineering and Materials (2013), 69(4), 405-413, database is CAplus and MEDLINE.

The authors have redetermined the known structures of (i) methylthiourea (MTU) and (ii) 1,1-dimethylthiourea (1,1-DMTU), and studied the structure of 1,3-dimethylthiourea (1,3-DMTU), which was however severely disordered. The authors report the structures of crystalline adducts of (iii) MTU with morpholine (1:1), (iv) 1,1-DMTU with 1,4-dioxane (2:1) and (v) 1,3-DMTU with 1,4-dioxane (2:1). Finally, (vi) the authors determined the structure of tetramethylthiourea (TetMTU). (i) In both independent mols. of MTU, the Me group is trans to the C=S group across the C-N bond. The two mols. are connected to form an R₂²(8) dimer by mutual N-H¡¤¡¤¡¤S=C interactions. The packing involves six N-H¡¤¡¤¡¤S=C interactions and is three-dimensional. (ii) The packing of the MTU-morpholine adduct is a layer structure, within which both mols. form linear aggregates parallel to the b axis. (iii) The packing of 1,1-DMTU involves N-H¡¤¡¤¡¤S=C H bonds forming a corrugated layer structure. (iv) In the 2:1 adduct between 1,1-DMTU and 1,4-dioxane, the DMTU mol. occupies a general position whereas the dioxane mol. lies across an inversion center. The crystal packing involves chains of alternating 1,1-DMTU R₂²(8) dimers and dioxanes, both across inversion centers. (v) In the 2:1 adduct between 1,3-DMTU and dioxane, the 1,3-DMTU mol. occupies a general position, while the dioxane mol. lies across an inversion center. One Me group of the DMTU is trans and one cis to the S across the corresponding C-N bond. The mols. form chains of alternating 1,3-DMTU R₂²(8) dimers and dioxanes, both across inversion centers. Crystals of the 2:1 adduct between 1,3-DMTU and morpholine were also obtained, and were isotypic with the dioxane adduct. The morpholine mol. is disordered across the inversion center. (vi) The mol. of TetMTU displays crystallog. 2-fold symmetry. Significant distortions reflect the steric pressure between Me groups trans to S. The packing of TetMTU involves only a weak H bond, C-H_methyl¡¤¡¤¡¤S, which connects the mols. to form layers. Crystallog. data are given.

Acta Crystallographica, Section B: Structural Science, Crystal Engineering and Materials published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia