Tag: M.W=200-250

Peschke, Bernd published the artcileCinnamic amides of (S)-2-(aminomethyl)pyrrolidines are potent H₃ antagonists, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry (2004), 12(10), 2603-2616, database is CAplus and MEDLINE.

New imidazole-free H₃ antagonists have been found in a series of cinnamic amides of (S)-(aminomethyl)pyrrolidines. The influence of the substituent on the aromatic moiety on the potency and the inhibition of three cytochrome P 450 subtypes are also described.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kunchur, Harish S. published the artcilePlatinum Assisted Tandem P-C Bond Cleavage and P-N Bond Formation in Amide Functionalized Bisphosphine o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o: Synthesis, Mechanistic, and Catalytic Studies, Category: catalysis-chemistry, the publication is Inorganic Chemistry (2022), 61(2), 857-868, database is CAplus and MEDLINE.

The reactions of amide functionalized bisphosphine o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o (1) with Pt salts is described. Treatment of 1 with [Pt(COD)Cl₂] yielded a chelate complex, [PtCl₂{o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o}κ²-P,P] (2), which on subsequent treatment with LiHMDS formed a novel 1,2-azaphospholene-phosphine complex [PtPhCl{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (3) involving a tandem P–C bond cleavage and P-N bond formation. The same complex 3 on passing dry HCl gas afforded dichloro-complex [PtCl₂{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (5). Complex 2 upon refluxing in toluene or treatment of 1 with [Pt(COD)Cl₂] in the presence of a base at room temperature resulted in pincer complex [PtCl{o-Ph₂PC₆H₄C(O)N(C₆H₄PPh₂-o)}κ³-P,N,P] (4). Reaction of 1 with [Pt(COD)ClMe] at room temperature also afforded the pincer complex [PtMe{o-Ph₂PC₆H₄C(O)N(C₆H₄PPh₂-o)}κ³-P,N,P] (6). Mechanistic studies on 1,2-azaphospholene formation showed the reductive elimination of LiCl to form a phosphonium salt that readily adds one of the P-C bonds oxidatively to the in situ generated Pt⁰ species to form a chelate complex 3. Analogous Pd complex [PdCl₂{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (7) showed excellent catalytic activity toward N-alkylation of amines with alcs. with a very low catalyst loading (0.05 mol %), and the methodol. is very efficient toward the gram scale synthesis of many N-alkylated amines.

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karasu, Feyza published the artcilePhotoinitiated polymerization of β-cyclodextrin/methyl methacrylate host/guest complex in the presence of water soluble photoinitiator, thioxanthone-catechol-O,O’-diacetic acid, HPLC of Formula: 5411-14-3, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2010), 68(1-2), 147-153, database is CAplus.

β-Cyclodextrin (β-CD) was used to complex the monomer, Me methacrylate (MMA), yielding a water-soluble host/guest complex. Photoinitiated polymerization of β-CD/MMA complex was achieved in the presence of thioxanthone-catechol-O,O’-diacetic acid (TX-Ct), a one component water soluble photoinitiator. Photodecarboxylation of TX-Ct in water seems to be an important reaction mechanism. Therefore, resulting alkyl radicals are able to initiate the polymerization of β-CD/MMA host/guest complex in water.

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O6, HPLC of Formula: 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Naik, Ravi published the artcileMethyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism, Name: 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is Journal of Medicinal Chemistry (2017), 60(20), 8631-8646, database is CAplus and MEDLINE.

Previously, the authors reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chem. biol. approach. Structure-activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective MDH1, MDH2, and dual inhibitors, which were used to study the relationship between MDH enzyme activity and HIF-1 inhibition. The authors hypothesized that dual inhibition of MDH1 and MDH2 might be a powerful approach to target cancer metabolism and selected methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)-benzoate (16c)as the most potent dual inhibitor. Kinetic studies revealed that compound 16c competitively inhibited MDH1 and MDH2. Compound 16c inhibited mitochondrial respiration and hypoxia-induced HIF-1α accumulation. In xenograft assays using HCT116 cells, compound 16c demonstrated significant in vivo antitumor efficacy. This finding provides concrete evidence that inhibition of both MDH1 and MDH2 may provide a valuable platform for developing novel therapeutics that target cancer metabolism and tumor growth.

Journal of Medicinal Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Name: 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Naik, Ravi published the artcileMethyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism, COA of Formula: C12H16O3, the publication is Journal of Medicinal Chemistry (2017), 60(20), 8631-8646, database is CAplus and MEDLINE.

Previously, the authors reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chem. biol. approach. Structure-activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective MDH1, MDH2, and dual inhibitors, which were used to study the relationship between MDH enzyme activity and HIF-1 inhibition. The authors hypothesized that dual inhibition of MDH1 and MDH2 might be a powerful approach to target cancer metabolism and selected methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)-benzoate (16c)as the most potent dual inhibitor. Kinetic studies revealed that compound 16c competitively inhibited MDH1 and MDH2. Compound 16c inhibited mitochondrial respiration and hypoxia-induced HIF-1α accumulation. In xenograft assays using HCT116 cells, compound 16c demonstrated significant in vivo antitumor efficacy. This finding provides concrete evidence that inhibition of both MDH1 and MDH2 may provide a valuable platform for developing novel therapeutics that target cancer metabolism and tumor growth.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guanti, Giuseppe published the artcileRegioselective synthesis of 1,8-dihydroxytetralins through a tandem reduction/intramolecular hydroxyalkylation of 4-(3-hydroxyphenyl)alkanoates, Name: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Tetrahedron (1994), 50(41), 11945-66, database is CAplus.

A series of 4-(3-hydroxyphenyl)butanoates, e.g., 3-HOC₆H₄(CH₂)₃CO₂Et, has been prepared and transformed into 1,8-dihydroxytetralins, e.g., I, by treatment with 2 equiv of DIBALH followed by quenching with aqueous NH₄Cl. A possible mechanism for this novel, totally regioselective intramol. hydroxyalkylation is suggested and the factors affecting the stability of 1,8-dihydroxytetralins are also discussed.

Tetrahedron published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Name: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Jia published the artcileCercosporin-bioinspired selective photooxidation reactions under mild conditions, Application of Bis(4-fluorophenyl)methane, the publication is Green Chemistry (2019), 21(22), 6073-6081, database is CAplus.

The development of an efficient system for selective oxidation of organic compounds to generate more valuable compounds with mol. oxygen is a significant challenge in industrial chem. Bioinspired by the ability of naturally occurring perylenequinonoid pigments (PQPs) to generate reactive oxygen species (ROS) upon photoirradiation, here we report that cercosporin, one of the perylenequinonoid pigments, can function as a cost-effective and environmentally friendly photocatalyst for a wide range of selective oxidations, including benzylic C-H bonds to carbonyls, amines to aldehydes, and sulfides to sulfoxides. All of the representative reactions proceeded smoothly with high efficiency under mild conditions. Owing to the use of inexpensive metal-free visible light-driven photocatalyst produced from microbial fermentation with cheap glucose as the starting material and the ease of handling, we expect that this developed method will be particularly attractive for many more applications in synthetic transformation.

Green Chemistry published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Application of Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thuery, Pierre published the artcileFunctionalized Aromatic Dicarboxylate Ligands in Uranyl-Organic Assemblies: The Cases of Carboxycinnamate and 1,2-/1,3-Phenylenedioxydiacetate, Computed Properties of 5411-14-3, the publication is Inorganic Chemistry (2020), 59(5), 2923-2936, database is CAplus and MEDLINE.

2-Carboxycinnamic acid (ccnH₂) and the isomeric 1,2- and 1,3-phenylenedioxydiacetic acids (1,2- and 1,3-pddaH₂) have been used to synthesize eight uranyl ion complexes under solvo-hydrothermal conditions. In the four complexes [PPh₄]₂[UO₂(ccn)(NO₃)]₂ (1), [PPh₄]₂[UO₂(ccn)(dibf)]₂ (2), [UO₂(ccn)(bipy)]₂ (3), and [Ni(R,S-Me₆cyclam)][UO₂(ccn)(HCOO)]₂ (4), the ccn^2- dianion retains a nearly planar geometry, which favors the formation of the centrosym. [UO₂(ccn)]₂ dimeric unit. Addnl. terminal ligands, either neutral (bipy = 2,2′-bipyridine) or anionic (nitrate, dibf^– = 1,3-dihydro-3-oxo-1-isobenzofuranacetate, and formate, the two latter formed in situ), complete the uranyl coordination sphere, leading in all cases to discrete, dinuclear species. Sodium(I) bonding to the carboxylate/ether O₄ site of the 1,2-pdda^2- dianion in the two complexes [UO₂Na(1,2-pdda)(OH)] (5) and [(UO₂)₂Na₂(1,2-pdda)₂(C₂O₄)] (6) results in this ligand being planar. Further lateral coordination to uranyl and sodium bonding to a uranyl oxo group allow formation of heterometallic diperiodic networks containing monoperiodic uranyl-only subunits. In the absence of Na⁺ cations, 1,2-pdda^2- adopts a conformation in which one carboxylate group is tilted out of the ligand plane in [UO₂(1,2-pdda)₂Ni(cyclam)] (7) and diaxial carboxylato bonding to nickel(II) unites uranyl-only monoperiodic subunits into a diperiodic network. The 1,3-pdda^2- ligand in [UO₂(1,3-pdda)(H₂O)] (8) is also nonplanar with one tilted carboxylate group, and the bridging bidentate nature of both carboxylate groups allows formation of a triperiodic framework in which both metal and ligand are four-coordinated nodes. While the emission spectra of complexes 1 and 5 display the vibronic progression considered typical of uranyl ion, those of complexes 2, 4, and 8 show broad emission bands which in the case of complex 4 completely replace the uranyl emission and which appear to be ligand-centered. The low energy of these broad bands can be rationalized in terms of the close association of certain ligand pairs within the structures. 2-Carboxycinnamate is a ligand with a marked tendency to planarity, which, in the presence of terminal coligands, consistently forms quasi-planar, dinuclear, dimeric units with the uranyl ion. In contrast, the isomeric 1,2- and 1,3-phenylenedioxydiacetates can adopt either planar or nonplanar conformations, leading to various di- and triperiodic assemblies.

Inorganic Chemistry published new progress about 5411-14-3. 5411-14-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2,2-(1,2-Phenylenebis(oxy))diacetic acid, and the molecular formula is C10H10O3, Computed Properties of 5411-14-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abel, Anton S. published the artcile6-Polyamino-substituted quinolines: synthesis and multiple metal (Cu^II, Hg^II and Zn^II) monitoring in aqueous media, Formula: C6H20Cl2N4, the publication is Organic & Biomolecular Chemistry (2019), 17(17), 4243-4260, database is CAplus and MEDLINE.

Chemoselective palladium-catalyzed arylation of polyamines with 6-bromoquinoline was explored to prepare chelators for the detection of metal cations in aqueous media. The introduction of a single aromatic moiety into non-protected polyamine mols. was achieved using the com. available Pd(dba)₂/BINAP precatalyst to afford nitrogen chelators, in which the aromatic signaling unit is directly attached to the polyamine residue. Water-soluble receptors were then synthesized using N-alkylation of these polyamines by hydrophilic coordinating residues. By combining rich photophys. properties of the 6-aminoquinoline unit with a high coordination affinity of chelating polyamines and a hydrophilic character of carboxamido-substituted phosphonic acid diesters in a single mol. device, the authors synthesized chemosensor 5 for selective double-channel (UV-visible and fluorescence spectroscopies) detection of Cu^II ions in aqueous media at physiol. levels. This receptor is suitable for the anal. of drinking water and fabrication of paper test strips for the naked-eye detection of Cu^II ions under UV-light. By increasing the number of donor sites the authors also obtained chemosensor 6 which is efficient for the detection of Hg^II ions. Moreover, chemosensor 6 is also suitable for multiple detection of metal ions because it chelates not only Hg^II but also Cu^II and Zn^II ions displaying different responses of emission in the presence of these three cations.

Organic & Biomolecular Chemistry published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Formula: C6H20Cl2N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saadat, Mostafa published the artcileSulfonic acid-functionalized magnetic carbon nitride as highly efficient ionic composite for sustainable assembly of 1,2,3-triazoles, Product Details of C10H11NO4, the publication is Journal of the Iranian Chemical Society (2021), 18(8), 2057-2064, database is CAplus.

An efficient and straightforward method for constructing of biol. active 4-aryl-NH-1,2,3-triazoles I [Ar = Ph, 2-BrC₆H₄, 2-thienyl, etc.] by the 1,3-dipolar cycloaddition reaction of β-nitrostyrene and sodium azide in the presence of acidic graphitic carbon nitride (Fe₃O₄@g-C₃N₄-SO₃H) ionic nanocomposite had developed. Using a magnetically recoverable acidic ionic catalyst allows eco-friendly and facile conversion and simplifies exptl. setup and work-up procedure that enables the direct synthesis of triazole derivatives under mild conditions. The designed catalytic system provided a broader scope under short reaction times in good to excellent yields. Fe₃O₄@g-C₃N₄-SO₃H could be simply recovered by magnetic separation using an external magnet, maintaining stable activity up to five cycles without appreciable loss of activity.

Journal of the Iranian Chemical Society published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia