Month: December 2022

Jash, Apratim published the artcileActivated release of bioactive aldehydes from their precursors embedded in electrospun poly(lactic acid) nonwovens, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is RSC Advances (2018), 8(36), 19930-19938, database is CAplus and MEDLINE.

Hexanal and benzaldehyde are naturally-occurring aroma compounds from plants with enzyme-inhibition and antimicrobial properties. Although useful for food preservation applications, the end-use of these compounds can be challenging due to their volatility and susceptibility to oxidative degradation In this study, stable precursors for benzaldehyde and hexanal were synthesized via reversible condensation reactions with N,N¡ä-dibenzylethane-1,2-diamine. The mol. structures of the resulting 1,3-dibenzylethane-2-Ph and 1,3-dibenzylethane-2-pentyl imidazolidines were confirmed by NMR analyses. The precursors were encapsulated in poly(lactic acid) fibers via electrospinning, using a 90 : 10 Et formate : DMSO blend as a solvent. Triggered release of benzaldehyde and/or hexanal from the resulting active nonwovens was achieved by the addition of 1 N citric acid, which can be described using a pseudo first order kinetic equation involving rapid and slow release steps.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giannola, Libero Italo published the artcileAddition reactions of acetylenic esters with monosubstituted thioureas, Recommanded Product: 1,1-Dimethylthiourea, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1978), 1428-31, database is CAplus.

Treating H₂NCSNHR (R = Et, Me) with MeO₂CCú·CCO₂Me gave 54 and 43% adducts I, and 22 and 38% adducts II, resp. Previous studies by J. W. Lown and J.C.N. Ma (1967) indicated the formation of only one product.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Premasagar, Vuppalapaty published the artcileMethanesulfonic acid catalyzed cyclization of 3-arylpropanoic and 4-arylbutanoic acids to 1-indanones and 1-tetralones, Computed Properties of 1949-41-3, the publication is Journal of Organic Chemistry (1981), 46(14), 2974-6, database is CAplus.

The title cyclizations were carried out by heating anhydrous MeSO₃H with the 3-arylpropanoic or 4-arylbutanoic acid at 110-15 and 90-5¡ã, resp. Using MeSO₃H as a Friedel-Crafts catalyst is not promising (2,4-Me₂C₆H₃COMe yield from m-xylene was ?30%).

Journal of Organic Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Computed Properties of 1949-41-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ragle, Lauren E. published the artcileDiscovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition, HPLC of Formula: 163839-73-4, the publication is Bioorganic & Medicinal Chemistry (2016), 24(19), 4660-4674, database is CAplus and MEDLINE.

Autotaxin (ATX) is a ubiquitous ectoenzyme that hydrolyzes lysophosphatidylcholine (LPC) to form the bioactive lipid mediator lysophosphatidic acid (LPA). LPA activates specific G-protein coupled receptors to elicit downstream effects leading to cellular motility, survival, and invasion. Through these pathways, upregulation of ATX is linked to diseases such as cancer and cardiovascular disease. Recent crystal structures confirm that the catalytic domain of ATX contains multiple binding regions including a polar active site, hydrophobic tunnel, and a hydrophobic pocket. This finding is consistent with the promiscuous nature of ATX hydrolysis of multiple and diverse substrates and prior investigations of inhibitor impacts on ATX enzyme kinetics. The current study used virtual screening methods to guide exptl. identification and characterization of inhibitors targeting the hydrophobic region of ATX. An initially discovered inhibitor, GRI392104 (IC₅₀ 4 ¦ÌM) was used as a lead for synthetic optimization. In total twelve newly synthesized inhibitors of ATX were more potent than GRI392104 and were selective for ATX as they had no effect on other LPC-specific NPP family members or on LPA_1-5 GPCR.

Bioorganic & Medicinal Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, HPLC of Formula: 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Occhialini, Gino published the artcileCatalytic, contra-Thermodynamic Positional Alkene Isomerization, Product Details of C15H24S, the publication is Journal of the American Chemical Society (2022), 144(1), 145-152, database is CAplus and MEDLINE.

The discovery of a dual catalyst system that promotes contra-thermodn. positional alkene isomerization under photochem. irradiation, providing access to terminal alkene isomers, e.g., (2-methylallyl)benzene directly from conjugated, internal alkene, e.g., (2-methylpropenyl)benzene starting materials was reported. The utility of the method is demonstrated in the deconjugation of diverse electron-rich/electron-poor alkenes and through strategic application to natural product synthesis, e.g., (-)-nopinone. Mechanistic studies are consistent with a regiospecific bimol. homolytic substitution (S_H2′) mechanism proceeding through an allyl-cobaloxime intermediate.

Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Product Details of C15H24S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kadari, Lingaswamy published the artcileIodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Organic Letters (2017), 19(10), 2580-2583, database is CAplus and MEDLINE.

A novel iodine-catalyzed functionalization of a variety of olefins and alkynes and direct decarboxylative functionalization of cinnamic and propiolic acids with TosMIC to provide access to various vinylic and allylic sulfones is described. This simple, efficient, and environmentally benign approach employing inexpensive mol. iodine as a catalyst demonstrates a versatile protocol for the synthesis of highly valuable sulfones, rendering it attractive to both synthetic and medicinal chem.

Organic Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Name: (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Das, Krishna Mohan published the artcileA novel quinoline-based NNN-pincer Cu(II) complex as a superior catalyst for oxidative esterification of allylic C(sp³)-H bonds, Application of 2-Methylbenzoic acid, the publication is Organic & Biomolecular Chemistry (2022), 20(17), 3540-3549, database is CAplus and MEDLINE.

A quinoline-based NNN-pincer Cu(II) complex acts as an air stable superior catalyst for the oxidative cross-coupling of the allyl sp³ C-H bond with an acid for the synthesis of allyl esters in a homogeneous system at ambient temperature The synthesized catalyst, Cu(II) complex has been well characterized by various anal. techniques (HRMS, single crystal X-ray diffraction, CV, EPR, UV-vis spectroscopy) and showed excellent catalytic activity for the oxidative esterification of allylic C(sp³)-H bonds at 40¡ãC within a very short period of time (1 h) using only 1 mol% of the catalyst. A wide variety of aromatic allylic esters were synthesized in moderate to good yields, which could be extended to aliphatic allyl esters as well.

Organic & Biomolecular Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Application of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Suguna, H. published the artcilePhotolytic syntheses of dl-anolobine and dl-9-hydroxy-2,3-methylenedioxyberbine, Quality Control of 1860-58-8, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1977), 15B(5), 416-18, database is CAplus.

Debenzylation of the isoquinoline I (R = PhCH2, R1 = Br) gave I (R = H, R1 = Br) and bromohydroxymethylenedioxyberbine II. Photolysis of I (R = H, R1 = Br).HCl gave (¡À)-anolobine (III), I (R = R1 = H), and II. II on reductive debromination gave 9-hydroxy-2,3-methylenedioxyberbine. IR spectrum of synthetic anolobine was identical with that of natural anolobine.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C21H37BO, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jadhav, Nikhil C. published the artcileDesign, synthesis and molecular docking study of novel pyrrole-based ¦Á-amylase and ¦Á-glucosidase inhibitors, Product Details of C10H11NO4, the publication is Medicinal Chemistry Research (2017), 26(10), 2675-2691, database is CAplus.

In an effort to design and synthesize a new class of ¦Á-glucosidase and ¦Á-amylase inhibitors, we have synthesized novel pyrrole based mols. using mol. hybridization approach. These novel analogs were synthesized by the novel methodol. developed in our lab which comprises of the multi-component direct synthesis route using hypervalent iodine reagent. The compounds were characterized by IR, ¹H NMR (NMR), ¹³C NMR and Mass Spectroscopy. These compounds were screened for their ¦Á-amylase and ¦Á- glucosidase activity. They showed a varying degree of inhibition with IC₅₀ values ranging between 0.4 to 4.14 ¦Ìmol/mL and 0.8 to 4.14 ¦Ìmol/mL for ¦Á-amylase and ¦Á-glucosidase resp. Compounds 3, 7, 12, and 18 showed excellent activity as compared to standard acarbose. This has identified a new class of ¦Á-amylase and ¦Á-glucosidase inhibitor which can be further developed as antihyperglycemic agents. The mol. docking anal. was carried out to better understand of interaction between ¦Á-amylase and ¦Á-glucosidase target and inhibitors in this series. We also generated a homol. model for human ¦Á-glucosidase enzyme and identified the key residues at the binding site. The outcome of the study could be used for the rational design of potent and selective ¦Á-amylase and ¦Á-glucosidase inhibitors, resp.

Medicinal Chemistry Research published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Padgett-Pagliai, Kaylie A. published the artcileOsmotic stress induces long-term biofilm survival in Liberibacter crescens, Computed Properties of 63-68-3, the publication is BMC Microbiology (2022), 22(1), 52, database is CAplus and MEDLINE.

Citrus greening, also known as Huanglongbing (HLB), is a devastating citrus plant disease caused predominantly by Liberibacter asiaticus. While nearly all Liberibacter species remain uncultured, here we used the culturable L. crescens BT-1 as a model to examine physiol. changes in response to the variable osmotic conditions and nutrient availability encountered within the citrus host. Similarly, physiol. responses to changes in growth temperature and DMSO concentrations were also examined, due to their use in many of the currently employed therapies to control the spread of HLB. Sublethal heat stress was found to induce the expression of genes related to tryptophan biosynthesis, while repressing the expression of ribosomal proteins. Osmotic stress induces expression of transcriptional regulators involved in expression of extracellular structures, while repressing the biosynthesis of fatty acids and aromatic amino acids. The effects of osmotic stress were further evaluated by quantifying biofilm formation of L. crescens in presence of increasing sucrose concentrations at different stages of biofilm formation, where sucrose-induced osmotic stress delayed initial cell attachment while enhancing long-term biofilm viability. Our findings revealed that exposure to osmotic stress is a significant contributing factor to the long term survival of L. crescens and, possibly, to the pathogenicity of other Liberibacter species.

BMC Microbiology published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Computed Properties of 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia