Month: December 2022

Moriyama, Doris Ferreira published the artcileThe effects of temperature variation treatments on embryonic development: a mouse study, SDS of cas: 63-68-3, the publication is Scientific Reports (2022), 12(1), 2489, database is CAplus and MEDLINE.

Since the development of ART, embryos have been cultured at 37 ¡ãC in an attempt to mimic the in vivo conditions and the average body temperature of an adult. However, a gradient of temperatures within the reproductive tract has been demonstrated in humans and several other mammalian species. Therefore, the aim of this study was to evaluate the effects of temperature variation treatments on mouse embryo quality through morphokinetic events, blastocyst morphol., the relative gene expression of Igf2, Bax, Bcl2 and Apaf1 and the metabolomics of individual culture media. Study groups consisted of 2 circadian treatments, T1 with embryos being cultured at 37 ¡ãC during the day and 35.5 ¡ãC during the night, T2 with 38.5 ¡ãC during the day and 37 ¡ãC during the night and a control group with constant 37 ¡ãC. Our main findings are that the lower-temperature group (T1) showed a consistent neg. effect on mouse embryo development with “slow” cleaving embryos, poor-quality blastocysts, a higher expression of the apoptotic gene Apaf1, and a significantly different set of amino acids representing a more stressed metabolism On the other hand, our higher-temperature group (T2) showed similar results to the control group, with no adverse effects on blastocyst viability.

Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuznetsov, V. V. published the artcile6,6′-Bis(1,5-diazabicyclo[3.1.0]hexane), Application of Propane-1,3-diamine dihydrochloride, the publication is Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) (1999), 48(3), 617-619, database is CAplus.

The interaction of 1,3-diaminopropane with glyoxal and NaOCl in water at pH 9.5-10.5 afforded the previously unknown 6,6′-bis(1,5-diazabicyclo[3.1.0]hexane)(I). According to X-ray diffraction data, both bicyclic fragments of I adopt a boat conformation.

Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Application of Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chatterjee, Sayanti published the artcileHydroxylamine-Derived Reagent as a Dual Oxidant and Amino Group Donor for the Iron-Catalyzed Preparation of Unprotected Sulfinamides from Thiols, SDS of cas: 1293990-73-4, the publication is Angewandte Chemie, International Edition (2021), 60(2), 758-765, database is CAplus and MEDLINE.

An iron catalyzed reaction for the selective transformation of thiols (-SH) to sulfinamides (-SONH₂) by a direct transfer of -O and free -NH₂ groups has been developed. The reaction operates under mild conditions using a bench stable hydroxylamine derived reagent, exhibits broad functional group tolerance, is scalable and proceeds without the use of any precious metal catalyst or addnl. oxidant. This novel, practical reaction leads to the formation of two distinct new bonds (S=O and S-N) in a single step to chemoselectively form valuable, unprotected sulfinamide products. Preliminary mechanistic studies implicate the role of the alc. solvent as an oxygen atom donor.

Angewandte Chemie, International Edition published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, SDS of cas: 1293990-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chakravarti, Duhkhaharan published the artcileSynthesis of coumarins from o-hydroxyaryl alkyl ketones. II. Formation of o-coumaric acids from o-hydroxyaldehydes, Formula: C11H12O4, the publication is Journal of the Indian Chemical Society (1939), 389-92, database is CAplus.

cf. C. A. 32, 7026.9; 33, 549.4. The Me ethers of the o-HO aldehydes condense with EtO₂CCH₂Br (I) and EtO₂CCHBrMe (II) to form trans-cinnamic esters, which do not yield coumarins on heating with HI or on standing with cold H₂SO₄ as do the esters obtained from o-hydroxyaryl alkyl ketones. A mixture of 11 g. o-MeOC₆H₄CHO in 50 cc. anhydrous benzene, 6 g. Zn wool and 16 g. I was heated at 100¡ã for 2 h. and poured into ice-cold dilute H₂SO₄. The washed and dried benzene layer was evaporated down and distilled, yielding 11 g. of o-MeOC₆H₄CH(OH)CH₂CO₂Et, b₁₀ 150-4¡ã, which was converted by heating with 6 g. SOCl₂ and 9 g. pyridine in ether into 10 g. Et 2-methoxy-trans-cinnamate, C₁₂H₁₄O₃, b₈ 150¡ã, hydrolyzed to 2-methoxy-trans-cinnamic acid, m. 182¡ã, identical with a specimen prepared from o-coumaric acid by methylation with Me₂SO₄ and hydrolysis. Similarly, o-MeOC₆H₄CHO was converted by Reformatski¨«’s reaction with Zn and II to o-MeC₆H₄CH(OH)CHMeCO₂Et, b₄ 155¡ã, transformed by SOCl₂ in the presence of pyridine to Et 2-methoxy-¦Á-methyl-trans-cinnamate, C₁₃H₁₆O₃, b₄ 150-5¡ã, hydrolyzed by alc. KOH to the corresponding acid, m. 102¡ã. Condensation of 2,4-(MeO)₂C₆H₃CHO with I gave 2,4-(MeO)₂C₆H₃CH(OH)CH₂CO₂Et, b₈ 180-4¡ã, dehydrated to the cinnamic ester, b₈ 180-4¡ã, hydrolyzed to 2,4-dimethoxy-trans-cinnamic acid, m. 184¡ã. To study the influence of a Ph substituent on the formation of trans-cinnamic esters, 8.5 g. of 5,2-Cl(MeO)C₆H₃CHO was condensed with 8.5 g. I to the propionate (8 g.) which, on dehydration with SOCl₂, gave 6 g. of Et 2-methoxy-5-chloro-trans-cinnamate, C₁₂H₁₃ClO₃, b₆ 170¡ã, hydrolyzed to the corresponding acid (III), m. 191¡ã. A sample of authentic III was prepared by treating 6-chlorocoumarin with HgO, methylating and hydrolyzing with alc. KOH. Thus it is shown that if there are no ¦Â-alkyl groups in the resulting cinnamic ester, the latter has the trans configuration. Otherwise the esters have the cis configuration and readily form coumarins. The 2-MeO aldehydes are useful starting materials for the preparation of o-coumaric acid derivatives in satisfactory yields. Condensation of 10 g. of 2,4-(MeO)₂C₆H₃Ac (IV) with 9 g. II and distillation of the product yielded 8.5 g. of Et 2,4-dimethoxy-¦Á,¦Â-dimethyl-cinnamate (V), b₆ 180-2¡ã, converted by standing overnight in cold H₂SO₄ (d. 1.84) to 3,4-dimethyl-7-methoxycoumarin, m. 140¡ã. Heating V (1 g.) with 7 cc. HI (d. 1.7) at 140¡ã for 2 h. gave colorless needles of 3,4-dimethyl-7-hydroxycoumarin, m. 256¡ã, on recrystallization from alc. Similarly, condensation of 10 g. IV with I gave an unsaturated ester, b₆ 174¡ã, on vacuum distillation No ring closure was effected by heating with HI or on treatment with cold H₂SO₄. Hydrolysis gave the known 2,4-dimethoxy-¦Â-methylcinnamic acid, m. 145¡ã.

Journal of the Indian Chemical Society published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bedane, Kibrom Gebreheiwot published the artcileFast and efficient synthesis of flavanones from cinnamic acids, SDS of cas: 1772-76-5, the publication is Synthetic Communications (2016), 46(22), 1803-1809, database is CAplus.

A fast and efficient synthesis of flavanones from cinnamic acids in three steps was developed. First, the cinnamic acids were converted to cinnamoyl chlorides using SOCl₂. The acid chlorides were then treated with substituted phenols in BF₃¡¤OEt₂ to furnish the corresponding chalcones in 42-75% yields. Base-catalyzed cyclization of the chalcones at room temperature afforded the corresponding flavanones in 85-95% yields. The conversion of the cinnamic acid derivatives to corresponding chalcones was found to be sensitive to the position and nature of the substituents on the aromatic rings.

Synthetic Communications published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, SDS of cas: 1772-76-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De, Soumya Kanti published the artcileLipid phase dependent distinct emission behaviour of hydrophobic carbon dots: C-dot based membrane probes, Recommanded Product: 2,2′-Dithiodibenzoic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(72), 9080-9083, database is CAplus and MEDLINE.

We observe a unique distinct emission behavior of hydrophobic carbon dots (H-CDs) embedded within the ordered and the disordered phase of a lipid membrane. The H-CDs exhibit blue emission in the disordered phase, however, they exhibit an intense red emission in the ordered phase of the lipid bilayer. The H-CDs have the potential ability to probe membrane dynamics like previously reported organic dyes. To the best of our knowledge, this is the first report of a CD-based membrane probe.

Chemical Communications (Cambridge, United Kingdom) published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Recommanded Product: 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rajadurai, Maruthamuthu published the artcilePhytochemical profiling of medically significant crude extract using GC-MS analysis, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is International Journal of Current Pharmaceutical Research (2018), 10(6), 16-20, database is CAplus.

The objective of this research is to identify the phytochem. constitutions present in Natural crude extract which obtained from Thumlappati district. Kidney stone is one of the most clin. disorder arising nowadays. They are existing due to the depletion of the urine and disproportionate execration of the components such as oxalate, phosphate, uric, cysteine, and struvite. Many alopathy medicine are not effectively curable in the case of kidney stone, consequently people are in need of traditional medicine system. Thus there is a great demand for research on potential inhibitor from natural products for dissolving kidney stone. In present work deals with an unknown crude extract collected from G. Thumlappati, Battalagundu Dindugal district Tamil Nadu. The crude extract of phytochem. are analyzed by using GCMS method. Thus the sample has some bioactive compound to discharge the stone particles. So we subjected the crude extract sample to GC-MS process which reveals 210 compounds in 21 different peaks. This studies forms a basis for the biol. characterization and importance of bioactive compounds were identified.

International Journal of Current Pharmaceutical Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cornea, Felicia published the artcileSynthesis and characterization of some new derivatives of (+)- and (-)- carvone, Category: catalysis-chemistry, the publication is Revistade Chimie (Bucharest, Romania) (1987), 38(7), 570-3, database is CAplus.

Carvone was treated with R¹ONH₂.HCl (R¹ = PhCH₂, methylbenzyl, CHPh₂, CPh₃, alkyl) and H₂NO(CH₂)_nONH₂.2HCl (n = 1, 2) to give oximes I and II. II (n = 1) was also prepared from carvone oxime and CH₂Cl₂.

Revistade Chimie (Bucharest, Romania) published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gaucher-Wieczorek, Florence S. published the artcileFluorous Tagged N-Hydroxy Phthalimide for the Parallel Synthesis of O-Aryloxyamines, Application In Synthesis of 30670-30-5, the publication is Journal of Combinatorial Chemistry (2010), 12(5), 655-658, database is CAplus and MEDLINE.

The parallel synthesis of O-aryloxyamines remains an unfulfilled need in the field of medicinal chem. and fragment-based approaches. To fill this gap a solution-phase two-step process based on (1) a copper-catalyzed cross-coupling of aryl boronic acids with a fluorous tagged N-hydroxyphthalimide, and (2) a supported aminolysis was designed and optimized using Taguchi’s method. A library of O-aryloxyamines was synthesized in high yields with high purity and diversity.

Journal of Combinatorial Chemistry published new progress about 30670-30-5. 30670-30-5 belongs to catalysis-chemistry, auxiliary class Polyfluoroalkanes, name is 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecan-1-amine, and the molecular formula is C10H6F17N, Application In Synthesis of 30670-30-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barolli, Joao P. published the artcileHeteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N’-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies, Product Details of C3H8N2S, the publication is Polyhedron (2017), 33-41, database is CAplus.

Ruthenium complexes were assessed as antitumor agents against cancer cells. In this project, new heteroleptic Ru(II) complexes [Ru(L)(bipy)(dppb)](PF₆) (L = N,N-disubstituted-N’-acylthiourea, bipy = 2,2′-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane) were synthesized and characterized by elemental anal., IR and NMR (¹H and ³¹P{¹H}) spectroscopies, molar conductivity measurements and single crystal x-ray diffractometry. The IR and NMR data suggest the coordination of the ligands to the Ru(II) metal center through the thiocarbonyl and carbonyl groups. The structures of the new complexes were further studied by x-ray crystallog., which confirmed the coordination of the ligands with the metal through the S and O atoms, giving distorted octahedral complexes. The N,N-disubstituted-N’-acylthioureas and their complexes were screened with respect to their in vitro cytotoxicity. All compounds exhibited considerable antiproliferative activity against MCF-7 (human breast tumor cells ATCC HTB-26), DU-145 (human prostate tumor cells ATCC HTB-26), and relatively low toxicity against fibroblast L929 cells (health cell line from mouse ATCC CCL-1). A preliminary study regarding the mechanism of action of these compounds by confocal microscopy shows alterations of the actin filaments leading to modifications in cytoskeletal supporting the cell death and that the cell nucleus is not the main target of these complexes.

Polyhedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Product Details of C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia