Catalysis-chemistry

Liao, Daohong published the artcileNecrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is MedChemComm (2014), 5(3), 333-337, database is CAplus.

Through high-throughput screening of 200 000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small mol. inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chem. genetic approach, we utilized an NSA based chem. probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.

MedChemComm published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yin, Ji-ming published the artcileCopper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo, Computed Properties of 38260-01-4, the publication is Inflammation Research (2016), 65(12), 1009-1020, database is CAplus and MEDLINE.

Objective: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. Radiofrequency ablation (RFA) is currently performed widely for managing HCC. RFA treatment causes damage around the ablation. Trientine dihydrochloride has been used to reduce the copper in liver. Methods: The rats were treated with trientine dihydrochloride for 5 days before liver RFA. Liver function, copper concentration, inflammation biomarkers and MDA, SOD were analyzed after RFA treatment for 2 h, 2 and 5 days. Results: The results indicated that trientine dihydrochloride reduced the copper in plasma and liver tissue significantly. And trientine dihydrochloride significantly inhibited RFA-induced inflammatory gene expression in liver. Similar inhibitory effects of trientine dihydrochloride were observed on ROS-induced malondialdehyde production in liver tissues. Conclusion: These results suggest that pre-treatment with the selective copper chelator trientine dihydrochloride can inhibit inflammatory response effectively during and after liver RFA in vivo. Chelation of copper to a lower level before liver RFA may be a novel strategy to prevent or ameliorate inflammatory responses in liver induced by RFA and to protect the parenchyma tissues in liver during and after RFA in HCC patients.

Inflammation Research published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C5H8N2O, Computed Properties of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Yi published the artcileMetagenomic and metatranscriptomic analyses reveal minor-yet-crucial roles of gut microbiome in deep-sea hydrothermal vent snail, Related Products of catalysis-chemistry, the publication is Animal Microbiome (2022), 4(1), 3, database is CAplus and MEDLINE.

Marine animals often exhibit complex symbiotic relationship with gut microbes to attain better use of the available resources. Many animals endemic to deep-sea chemosynthetic ecosystems host chemoautotrophic bacteria endocellularly, and they are thought to rely entirely on these symbionts for energy and nutrition. Numerous investigations have been conducted on the interdependence between these animal hosts and their chemoautotrophic symbionts. The provannid snail Alviniconcha marisindica from the Indian Ocean hydrothermal vent fields hosts a Campylobacterial endosymbiont in its gill. Unlike many other chemosymbiotic animals, the gut of A. marisindica is reduced but remains functional; yet the contribution of gut microbiomes and their interactions with the host remain poorly characterised. Metagenomic and metatranscriptomic analyses showed that the gut microbiome of A. marisindica plays key nutritional and metabolic roles. The composition and relative abundance of gut microbiota of A. marisindica were different from those of snails that do not depend on endosymbiosis. The relative abundance of microbial taxa was similar amongst three individuals of A. marisindica with significant inter-taxa correlations. These correlations suggest the potential for interactions between taxa that may influence community assembly and stability. Functional profiles of the gut microbiome revealed thousands of addnl. genes that assist in the use of vent-supplied inorganic compounds (autotrophic energy source), digest host-ingested organics (carbon source), and recycle the metabolic waste of the host. In addition, members of five taxonomic classes have the potential to form slime capsules to protect themselves from the host immune system, thereby contributing to homeostasis. Gut microbial ecol. and its interplay with the host thus contribute to the nutritional and metabolic demands of A. marisindica. The findings advance the understanding of how deep-sea chemosymbiotic animals use available resources through contributions from gut microbiota. Gut microbiota may be critical in the survival of invertebrate hosts with autotrophic endosymbionts in extreme environments.

Animal Microbiome published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C6H3ClFNO2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tsuei, Michael published the artcileInterfacial Polyelectrolyte-Surfactant Complexes Regulate Escape of Microdroplets Elastically Trapped in Thermotropic Liquid Crystals, Quality Control of 71989-31-6, the publication is Langmuir (2022), 38(1), 332-342, database is CAplus and MEDLINE.

Polyelectrolytes adsorbed at soft interfaces are used in contexts such as materials synthesis, stabilization of emulsions, and control of rheol. Here, we explore how polyelectrolyte adsorption to aqueous interfaces of thermotropic liquid crystals (LCs) influences surfactant-stabilized aqueous microdroplets that are elastically trapped within the LC. We find that adsorption of poly(diallyldimethylammonium chloride) (PDDA) to the interface of a nematic phase of 4-cyano-4¡ä-pentylbiphenyl (5CB) triggers the ejection of microdroplets decorated with sodium dodecylsulfate (SDS), consistent with an attractive elec. double layer interaction between the microdroplets and LC interface. The concentration of PDDA that triggers release of the microdroplets (millimolar), however, is three orders of magnitude higher than that which saturates the LC interfacial charge (micromolar). Observation of a transient reorientation of the LC during escape of microdroplets leads us to conclude that complexes of PDDA and SDS form at the LC interface and thereby regulate interfacial charge and microdroplet escape. Poly(sodium 4-styrenesulfonate) (PSS) also triggers escape of dodecyltrimethylammonium bromide (DTAB)-decorated aqueous microdroplets from 5CB with dynamics consistent with the formation of interfacial polyelectrolyte-surfactant complexes. In contrast to PDDA-SDS, however, we do not observe a transient reorientation of the LC when using PSS-DTAB, reflecting weak association of DTAB and PSS and slow kinetics of formation of PSS-DTAB complexes. Our results reveal the central role of polyelectrolyte-surfactant dynamics in regulating the escape of the microdroplets and, more broadly, that LCs offer the basis of a novel probe of the structure and properties of polyelectrolyte-surfactant complexes at interfaces. We demonstrate the utility of these new insights by triggering the ejection of microdroplets from LCs using peptide-polymer amphiphiles that switch their net charge upon being processed by enzymes. Overall, our results provide fresh insight into the formation of polyelectrolyte-surfactant complexes at aqueous-LC interfaces and new principles for the design of responsive soft matter.

Langmuir published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C15H14O3, Quality Control of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thoke, Mahesh Bhagwan published the artcileUnimolecular cooperative metallaphotocatalysis with conjugately bridged Ir-Ni complexes and its applications in organic coupling reactions, Safety of 2-Methylbenzoic acid, the publication is Organic Chemistry Frontiers (2022), 9(7), 1797-1807, database is CAplus.

Recent advances successfully upgraded the unique cooperative partnership between two distinct metals in photocatalysis. Herein we report the design, synthesis and comprehensive study of a series of heteroleptic Ir(III) complexes with a pendant binding site for nickel. The neutral Ir¡¤L^pytz complexes are apt to generate a novel unimol. Ir-Ni bimetallic system in situ during photocatalytic organic transformations where the pyridyl triazole ligand (L^pytz) acts as the conjugated bridge between Ir and Ni metal centers. A comparative study revealed that the bimetallic unimol. system with a conjugated linker is a convenient alternative to a bimol. system. UV-visible and photoluminescence quenching studies showed the importance of the conjugated bridging ligand to vectorial transfer of electrons from the photosensitizer unit to the reaction site. All novel Ir¡¤L^pytz complexes were evaluated in three challenging, mechanistically distinct photoinduced cross-coupling reactions (C-O, C-S and C-N) to demonstrate the enormous potential of a conjugately bridged Ir-Ni catalytic system, thus representing an alternative unimol. bimetallic strategy for photocatalytic Ni mediated cross-coupling reactions.

Organic Chemistry Frontiers published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C6H6N2O, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Wenxue published the artcileDesign, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents, COA of Formula: C10H10O3, the publication is Bioorganic Chemistry (2022), 105906, database is CAplus and MEDLINE.

In this study, a series of potential candidate mols. with excellent antitumor activity targeting tubulin and PTEN/PI3K/Akt signaling pathway was synthesized by modifying the mol. structure of podophyllotoxin (PPT) at the C-4 position via a structure-guided drug design approach. MTT assay results indicated that compound 12c had stronger anti-proliferative activities against HGC-27, MCF-7 and H460 cell lines than etoposide (VP-16), especially for HGC-27 (12c: IC50 = 0.89 ¡À 0.023 ¦ÌM; PPT: IC50 = 6.54 ¡À 0.69 ¦ÌM, VP-16: IC50 = 2.66 ¡À 0.28 ¦ÌM) with lower affect in healthy human cells (293 T and GES-1). Further pharmacol. anal. exhibited that 12c could bind the tubulin at the colchicine site and disrupt the dynamic equilibrium of microtubules. Moreover, 12c also suppressed the expressions/activities of matrix metalloprotease (MMP)-2, vimentin and up-regulation E-cadherin suggesting that 12c could block the epithelial-mesenchymal transition (EMT). The increased cell survival and invasion/migration were associated with the inactivation of PTEN/PI3K/Akt, 12c could regulate this pathway and cascade influence on the mitochondrial pathway, eventually, leading to the cell apoptosis. Thus, 12c may have the potential to become a candidate mol. in gastric cancer clin. treatment.

Bioorganic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C13H13BO2S, COA of Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xiang, Jing published the artcileThe highly chemoselective transfer hydrogenation of the carbon-carbon double bond of conjugated nitroalkenes by a rhodium complex, Product Details of C10H11NO4, the publication is Tetrahedron (2012), 68(24), 4609-4620, database is CAplus.

Chemoselective transfer hydrogenation of conjugated nitroalkenes catalyzed by [RhCl₂Cp^*]₂-diamine complex (Cp^*=¦Ç⁵-C₅Me₅) using HCOOH/Et₃N (5:2) (TEAF) as a hydrogen source was realized. A variety of nitrostyrenes, ¦Â-Me nitrostyrenes, and 3-methyl-4-nitro-5-alkenyl-isoxazoles were reduced smoothly in good to excellent yields in short reaction time. Other functional groups are inert under the reaction conditions.

Tetrahedron published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C17H20ClN3, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Andrews, Keith G. published the artcileCatalytic reductive N-alkylation of amines using carboxylic acids, Recommanded Product: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(9), 1855-1858, database is CAplus and MEDLINE.

A catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids is reported. The two-phase process involved silane mediated direct amidation followed by catalytic reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Recommanded Product: 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hashem, M. A. published the artcileOne step N-arylation of amines catalyzed by a non-toxic copper complex, Product Details of C12H9N3O4, the publication is Bangladesh Journal of Scientific and Industrial Research (2017), 52(1), 53-60, database is CAplus.

A new, simple and efficient copper-catalyzed method using a non-toxic copper complex has been developed for arylation of aromatic and heterocyclic amines with aryl halides. The copper complex was prepared from N-Ph salicylaldimine and Cu₂Br₂ in methanol.

Bangladesh Journal of Scientific and Industrial Research published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Product Details of C12H9N3O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ahmadi, Saba published the artcileThe landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid, the publication is Nature Communications (2022), 13(1), 1613, database is CAplus and MEDLINE.

Mining a large cohort of single-cell transcriptomics data, here we employ combinatorial optimization techniques to chart the landscape of optimal combination therapies in cancer. We assume that each individual therapy can target any one of 1269 genes encoding cell surface receptors, which may be targets of CAR-T, conjugated antibodies or coated nanoparticle therapies. We find that in most cancer types, personalized combinations composed of at most four targets are then sufficient for killing at least 80% of tumor cells while sparing at least 90% of nontumor cells in the tumor microenvironment. However, as more stringent and selective killing is required, the number of targets needed rises rapidly. Emerging individual targets include PTPRZ1 for brain and head and neck cancers and EGFR in multiple tumor types. In sum, this study provides a computational estimate of the identity and number of targets needed in combination to target cancers selectively and precisely.

Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Recommanded Product: (S)-2-Amino-4-(methylthio)butanoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia