Gad, Nourhan M. published the artcileReactivity of 5-phenyl-3-[(2-chloroquinolin-3-yl)methylene]furan-2(3H)-one towards hydrazine and benzylamine: A comparative study, Application In Synthesis of 2051-95-8, the publication is Synthetic Communications (2021), 51(9), 1384-1397, database is CAplus.
The reactivity of a 2-chloroquinolinylfuranone derivative was investigated against two nitrogen nucleophilic reagents namely, hydrazine and benzylamine. It was found that the regioselectivity of the reaction products was mainly dependent on the nature of nucleophiles, reaction conditions and solvent used. Therefore, hydrazinolysis of afforded the corresponding acid hydrazide and pyridazinone derivatives depending on the reaction conditions. Otherwise, benzylamine reacted with at different reaction aspects to provide N-benzylamide, N-benzylpyrrolone, and 2-benzylaminoquinolinyl-N-benzylpyrrolone derivatives The chem. structures of all synthesized compounds were substantiated from their anal. as well as spectroscopic data. Based on the charge d. calculations and computational chem. study which excluded the aza-Michael addition reaction and confirm the higher electron-deficiency of lactone carbonyl group than C2-quinoline position, it could be concluded that the C2-furanone becomes more susceptible to attack by the nucleophilic reagent, hydrazine and benzylamine.
Synthetic Communications published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Application In Synthesis of 2051-95-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia