Hermant, Paul published the artcileControlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox, HPLC of Formula: 1949-41-3, the publication is Journal of Medicinal Chemistry (2017), 60(21), 9067-9089, database is CAplus and MEDLINE.
Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas. Some hydroxamic acids display a high plasma clearance resulting in poor in vivo activity, though they may be very potent compounds in vitro. The authors designed a 57-member library of hydroxamic acids to explore the structure-plasma stability relationships in these series and to identify which enzyme(s) and which pharmacophores are critical for plasma stability. Arylesterases and carboxylesterases were identified as the main metabolic enzymes for hydroxamic acids. Finally, the authors suggest structural features to be introduced or removed to improve stability. This work thus provides the first medicinal chem. toolbox (exptl. procedures and structural guidance) to assess and control the plasma stability of hydroxamic acids and realize their full potential as in vivo pharmacol. probes and therapeutic agents. This study is particularly relevant to preclin. development as it allows obtaining compounds equally stable in human and rodent models.
Journal of Medicinal Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, HPLC of Formula: 1949-41-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia