Moore, Thomas M. published the artcileEffect of leaving group substituents on the microfluidic synthesis of [18F]3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ([18F]FPEB), Safety of Tetraethylammonium hydrogencarbonate, the publication is Heterocycles (2017), 95(2), 807-815, database is CAplus.
A com. microfluidic reactor system was used to synthesize the mGLUR5 receptor imaging agent [18F]FPEB. To study the effect of leaving group substituents on the synthesis of the desired compound, the chloro-, bromo-, iodo- and nitro-substituted precursors for FPEB were evaluated. Precursor concentrations of 4-10 mg/mL were evaluated in various solvents, with temperature ranges between 120 and 220° and total processing times of less than five minutes. Optimized incorporation yields ranged from 5% to 69.4% depending on the precursor used.
Heterocycles published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Safety of Tetraethylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia