Pascali, Claudio published the artcileSimple preparation and purification of ethanol-free solutions of 3′-deoxy-3′-[18F]fluorothymidine by means of disposable solid-phase extraction cartridges, Computed Properties of 17351-62-1, the publication is Nuclear Medicine and Biology (2012), 39(4), 540-550, database is CAplus and MEDLINE.
3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochem. yields and the use of a troublesome HPLC separation Moreover, a high content of ethanol, at least one-fold higher than the European Pharmacopoeia and US Pharmacopoeia’s established limit, is always present in the final product. The present study reports an optimization of the reaction conditions and a simple and straightforward purification step which affords a solution of [18F]FLT suitable for human use. Several conditions and materials were tested for both the nucleophilic substitution and purification step. The latter was achieved by means of a series of com. solid-phase extraction cartridges. Very conveniently, the whole one-pot synthesis was carried out on com. automated modules using basically the same setup employed for the synthesis of [18F]FDG. Under routine conditions, radiochem. yields of 37% [decay-corrected to start of synthesis (SOS)] were achieved in ca. 39 min from SOS, with radiochem. purities >98% (usually >99%). The negligible radiolysis observed could be easily suppressed by adding 0.5% of EtOH. Typical unlabeled chem. impurities detected were thymidine (0.15 ppm), thymine (0.28 ppm) and stavudine (0.05 ppm). A reliable, simple and efficient preparation of [18F]FLT has been developed, able to afford an ethanol-free solution of the tracer with no need for any HPLC purification Because of its similarity to the [18F]FDG synthesis, the method can be readily implemented on basically all the com. modules developed for this common radiotracer.
Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Computed Properties of 17351-62-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia