Romagnoli, Romeo published the artcileDesign, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2014), 394-407, database is CAplus and MEDLINE.
The combination of two pharmacophores into a single mol. represents one of the methods that can be adopted for the synthesis of new anticancer mols. A series of novel antiproliferative agents designed by a pharmacophore hybridization approach, combining the arylcinnamide skeleton and an α-bromoacryloyl moiety, was synthesized and evaluated for its antiproliferative activity against a panel of seven human cancer cell lines. In addition, the new derivatives were also active on multidrug-resistant cell lines over-expressing P-glycoprotein. The biol. effects of various substituents on the N-Ph ring of the benzamide portion were also described. In order to study the possible mechanism of action, 2-Bromo-N-(3-{(1E)-3-oxo-3-[(4-morpholinophenyl)amino] prop-1-en-1-yl}phenyl)-acrylamide slightly increased the Reactive Oxygen Species (ROS) production in HeLa cells, but, more importantly, a remarkable decrease of intracellular reduced glutathione content was detected in treated cells compared with controls. These results were confirmed by the observation that only thiol-containing antioxidants were able to significantly protect the cells from induced cell death. Altogether the authors’ results indicate that the new derivatives are endowed with good anticancer activity in vitro, and their properties may result in the development of new cancer therapeutic strategies.
European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia