So, Wing Ho published the artcileOn-resin Ugi reaction for C-terminally modified and head-to-tail cyclized antibacterial peptides, Category: catalysis-chemistry, the publication is Organic Letters (2021), 23(21), 8277-8281, database is CAplus and MEDLINE.
Here we report a method to synthesize C-terminally modified peptides on resin. A four-component Ugi reaction of isocyanide resin, an Fmoc-protected (Fmoc = 9-fluorenylmethoxycarbonyl) amino acid, an amine, and a 6-nitroveratrylaldehyde gives C-terminal photo-caged peptide amides, which can be photolyzed to generate C-terminal peptide amides. Changing the amine component in the Ugi reaction gives peptides with different C-terminal modifications including substituted anilides, alkyne, and azide. By installing an N-terminal azide and C-terminal alkyne, we synthesized a head-to-tail cyclized antibacterial peptide through copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The cyclized peptide exhibited higher proteolytic stability and antibacterial activity than the linear peptide.
Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C26H45N5O7Si2, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia