Swain, Baijayantimala published the artcileNew coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation, COA of Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2020), 28(15), 115586, database is CAplus and MEDLINE.
Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC6H4, 4-MeOC6H4, etc.] and sulfocoumarins II [Ar1 = 4-FC6H4, 3-F3CC6H4, 4-NCC6H4, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC6H4] and II [Ar1 = 4-NCC6H4] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)2C6H3] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC6H4, 3,4-(OMe)2C6H3] and II [Ar1 = 4-NCC6H4] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.
Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C18H14BrNO3, COA of Formula: C11H12O4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia