Tan, Jin-Fay published the artcileAlkynyl Triazenes as Fluoroalkyne Surrogates: Regioselective Access to 4-Fluoro-2-pyridones by a Rh(III)-Catalyzed C-H Activation-Lossen Rearrangement-Wallach Reaction, Synthetic Route of 1293990-73-4, the publication is ACS Catalysis (2020), 10(6), 3790-3796, database is CAplus.
A highly regioselective synthesis of 4-fluoro-2-pyridones using 1-alkynyl triazenes as a convenient fluoroalkyne surrogates was reported. The protocol comprises an alkenyl C-H annulation with 1-alkynyl triazenes followed by a treatment with HF·pyridine smoothly delivering a broad range of 4-fluoro-2-pyridones in a one-pot fashion in 90 min at 23-60 C. Notably, a rare Lossen rearrangement occurs during the C-H functionalization part of the transformation, allowing selective access to the less-available 4-fluoro-2-pyridone framework. Furthermore, the triazenyl intermediate was elaborated into addnl. fluorine-containing substituents like fluorinated alkoxy and trifluoromethyl groups.
ACS Catalysis published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C12H10F2Si, Synthetic Route of 1293990-73-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia