Wagner, Patrick published the artcilet-BuXPhos: a highly efficient ligand for Buchwald-Hartwig coupling in water, Application In Synthesis of 1237588-12-3, the publication is Green Chemistry (2014), 16(9), 4170-4178, database is CAplus.
An efficient and versatile ‘green’ catalytic system for the Buchwald-Hartwig cross-coupling reaction in water is reported. In an aqueous micellar medium, the combination of t-BuXPhos with [(cinnamyl)PdCl]2 showed excellent performance for coupling of aryl bromides or chlorides with a large set of amines, amides, ureas, and carbamates. The method is functional-group tolerant, proceeds smoothly (30 to 50 °C), and provides rapid access to the target compounds in good to excellent isolated yields. When applied to the synthesis of a known NaV1.8 modulator, this method led to a significant improvement of the E-factor in comparison with classical organic synthesis.
Green Chemistry published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C4H6O3, Application In Synthesis of 1237588-12-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia