An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted ‘click-chemistry’ was written by Bakleh, M. E.;Sol, V.;Estieu-Gionnet, K.;Granet, R.;Deleris, G.;Krausz, P.. And the article was included in Tetrahedron in 2009.SDS of cas: 57412-08-5 The following contents are mentioned in the article:
Synthetic cyclopeptides, and particularly those derived from vascular endothelial growth factor (VEGF) sequence, present considerable interest for the development of nanodevices devoted to tumor imaging or targeting. In order to provide selective peptide-targeted tetrapyrrolic structures, the authors designed two meso-porphyrin derivatives anchored to a 17-residue-long cyclopeptide, potent antagonist of VEGF receptors, via a flexible tetraethylene glycol chain. Anchoring was achieved by two different strategies: a classical secondary amide bond formation and microwave-assisted Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click-chem.). These compounds appear to be promising candidates for applications in photodynamic therapy (PDT). This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5SDS of cas: 57412-08-5).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Ligand, in chemistry, any atom or molecule attached to a central atom, usually a metallic element, in a coordination or complex compound. Chiral compounds with high purities and ee values are often used as ligands for catalytically active metal complexes. SDS of cas: 57412-08-5
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI