Platinum(II) complexes with porphyrin ligands: synthesis and synergisms in the photodynamic tumor therapy was written by Brunner, Henri;Obermeier, Herbert;Szeimies, Rolf-Markus. And the article was included in Chemische Berichte in 1995.Application of 57412-08-5 The following contents are mentioned in the article:
Twelve porphyrin ligands and their Pt(II) complexes were synthesized and characterized. Nine of the porphyrins are derived from hemin, and three are based on tetraphenylporphyrin. The ligands were transformed into diammine-dicarboxylatoplatinum(II) complexes and diamine-dichloroplatinum(II) complexes. The antitumor activity in the photodynamic therapy of the ligands and their complexes was tested in vitro towards the MDA-MB-231 mammary carcinoma cell line. The results obtained showed an additive effect on the photodynamic activity of the porphyrin skeleton when irradiation with visible red light and the cytotoxic activity of the Pt moiety in the complexes. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Application of 57412-08-5).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Catalytic transformations have become a mainstay in the toolkit of the synthetic and increasing non-synthetic chemist alike. Precious metals and metal oxides on carrier materials are used in many industrial processes as heterogenous catalysts.Application of 57412-08-5
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI