Microwave-assisted expeditious O-alkylation of meso-hydroxyphenylporphyrins was written by Chaleix, Vincent;Couleaud, Pierre;Sol, Vincent;Zerrouki, Rachida;Alves, Sandra;Krausz, Pierre. And the article was included in Journal of Porphyrins and Phthalocyanines in 2009.Recommanded Product: 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol The following contents are mentioned in the article:
A mild method for O-alkylation of meso-hydroxyphenylporphyrin was developed using microwave irradiation This method is clean and efficient for many substrates and resulted in significant improvement in reaction yield and a dramatic decrease in reaction time in comparison to thermal heating. E.g., hydroxyphenylporphyrin I [R = C6H4-4-Me, R1 = H] was reacted with BrCH2CO2Et in DMF using K2CO3 under microwave irradiation for 5 min gave the O-alkylation product I [R = C6H4-4-Me, R1 = CH2CO2Et] with 95% yield. Similar reactions gave O-alkylation products, such as I [R = C6H4-4-Me, R1 = (CH2)3OCOMe, (CH2)3CO2Et, CH2CH:CH2, CH2Cú·CH, CH2CO2CMe3, CH(CH2Me)CO2Me], with high yields. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Recommanded Product: 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Ligand design occupies a central place in organic synthesis and catalysis. Chiral compounds with high purities and ee values are often used as ligands for catalytically active metal complexes. Recommanded Product: 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI