Synthesis of porphyrinyl nucleosides was written by Czuchajowski, Leszek;Habdas, Jan;Niedbala, Halina;Wandrekar, Vinay. And the article was included in Journal of Heterocyclic Chemistry in 1992.Computed Properties of C47H36N4O The following contents are mentioned in the article:
Several porphyrinyl nucleosides were prepared in the reaction of the OH group of one, two, or four meso–p-hydroxyphenyl substituents of porphyrin with 5′-O-tosylates of 2′,3′-O-isopropylidene-adenosine or -uridine, or 5′-O-tosylthymidine; the remaining porphyrin meso-substituents were p-tolyl, p-hydroxyphenyl, or 4-pyridyl. The following porphyrinyl nucleosides were obtained with 8-17% yield: meso-di(p-tolyl)di(p-phenylene-5′-O-2′,3′-O-isopropylidene-adenosine) (or -uridine)porphyrins, the resp. meso-tetranucleoside-porphyrins 3,4-meso-mono(p-phenylene-5′-O-thymidine)porphyrins, meso-di(p-tolyl)di(p-phenylene-5′-O-thymidine)porphyrins and the meso-di(p-hydroxyphenyl)di(p-phenylene-5′-O-thymidine)porphyrins. Other compounds prepared belonged to the series: meso-(4-pyridyl)4-n(p-phenylene-5′-O-2′,3′-O-isopropylideneuridine)nporphyrin, n = 1,2,4. N-Methylation gave the water soluble iodide salts: (N-methyl-4-pyridinium)4-n(p-phenylene-5′-O-2′,3′-isopropylideneuridine)nporphyrins, n = 1, 2,4. The porphyrins meso disubstituted by thymidine represent a convenient substrate for the build-up of both nucleoside units into the oligo/polynucleotide chains. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Computed Properties of C47H36N4O).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Ligands, especially phosphines and carbenes, can play a key role in modifying and controlling homogeneous organometallic catalysts. Replacing precious metals with cheaper and more environmentally friendly metals is regarded as a highly desirable goal in the field of catalysis.Computed Properties of C47H36N4O
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI