Synthesis and biological evaluation of thioglycosylated porphyrins for an application in photodynamic therapy was written by Sylvain, I.;Zerrouki, R.;Granet, R.;Huang, Y. M.;Lagorce, J.-F.;Guilloton, M.;Blais, J.-C.;Krausz, P.. And the article was included in Bioorganic & Medicinal Chemistry in 2001.Product Details of 57412-08-5 The following contents are mentioned in the article:
The aim of this work is the synthesis of a new family of glycosylated porphyrins in which the sugar moieties are linked to the tetrapyrrole ring by a thioglycosidic bond. Two series have been designed: the first one corresponds to meso-aryl porphyrin derivatives; the second one has been obtained from protoporphyrin IX derivatization. Aryl-porphyrins were prepared from tristolyl o- and p-hydroxyporphyrins followed by bromoallylation and thioglycosylation with peracetylated S-glucose, mannose and galactose and deprotection. The other series has been synthesized from protoporphyrin IX dimethylester with a regioselective glycosylation of terminal alkenyl carbon. The UV-visible, NMR and MALDI mass spectra are presented. Photocytotoxicities of the synthesized compounds against K562 chronic leukemia cell line has been evaluated. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Product Details of 57412-08-5).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Catalytic transformations have become a mainstay in the toolkit of the synthetic and increasing non-synthetic chemist alike. The actual catalysts are metal complexes that are prepared from ligands and appropriate metal precursors.Product Details of 57412-08-5
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI