Alauddin, Mian M. published the artcileSynthesis of [18F]-labeled 2′-deoxy-2′-fluoro-5-methyl-1-¦Â-D-arabinofuranosyluracil ([18F]-FMAU), Safety of Tetrabutylammonium hydrogencarbonate, the publication is Journal of Labelled Compounds & Radiopharmaceuticals (2002), 45(7), 583-590, database is CAplus.
Synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-¦Â-D- arabinofuranosyluracil ([18F]-FMAU) is reported. 2-Deoxy-2-[18F]fluoro-1,3,5-tri-O-benzoyl-¦Á-D-arabinofuranose was prepared by the reaction of the resp. triflate with tetrabutylammonium[18F]fluoride. The fluorosugar was converted to its 1-bromo-derivative and coupled with protected thymine. The crude product mixture was hydrolyzed in base and purified by HPLC to obtain the radiolabeled FMAU (I). The radiochem. yield of I was 20-30% decay corrected (d.c.) in four steps with an average of 25% in four runs. Radiochem. purity was >99% and average specific activity was 2300 mCi/¦Ìmol at the end of synthesis (EOS). The synthesis time was 3.5-4.0h from the end of bombardment (EOB).
Journal of Labelled Compounds & Radiopharmaceuticals published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Safety of Tetrabutylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia