Arienzo, Rosa published the artcileStructure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(15), 4099-4102, database is CAplus and MEDLINE.
A new series of 2-aminoquinolines, e.g. I [R1R2N = N-methylpiperazino, morpholino, piperidino, etc.; R1 = Me2CH, cyclopentyl, R2 = H; R1 = Me, PhCH2, R2 = Me; R3 = Ph, 4-ClC6H4, 4-F3CC6H4, 2,4-Cl2C6H3, etc.] has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.
Bioorganic & Medicinal Chemistry Letters published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia