Guo, Jing published the artcileNovel Shikonin Derivatives Targeting Tubulin as Anticancer Agents, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Chemical Biology & Drug Design (2014), 84(5), 603-615, database is CAplus and MEDLINE.
In this study, the authors report the identification of a new shikonin-phenoxyacetic acid derivative, as an inhibitor of tubulin. A series of compounds were prepared; among them, compound 16 [(R) -1 – (5, 8- dihydroxy-1, 4- dioxo-1, 4- dihydronaphthalen-2-yl)-4-methylpent-3-enyl 2- (4- phenoxyphenyl) acetate] potently inhibited the function of microtubules, inducing cell growth inhibition, apoptosis of cancer cell lines in a concentration and time-dependent manner. Mol. docking involving compound 16 at the vinblastine binding site of tubulin indicated that a phenoxy moiety interacted with tubulin via hydrogen bonding with asparaginate (Asn) and tyrosine (Tyr). Anal. of microtubules with confocal microscopy demonstrated that compound 16 altered the microtubule architecture and exhibited a significant reduction in microtubule d. Cell cycle assay further proved that HepG2 cells were blocked in G2/M phase. The authors’ study provides a new, promising compound for the development of tubulin inhibitors by proposing a new target for the anticancer activity of shikonin.
Chemical Biology & Drug Design published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia