Hohn, Michael published the artcileSynthesis and Preliminary In Vitro and In Vivo Evaluation of Thiirane-Based Slow-Binding MMP Inhibitors as Potential Radiotracers for PET Imaging, Category: catalysis-chemistry, the publication is ChemistrySelect (2018), 3(42), 11729-11736, database is CAplus.
Many serious diseases such as cancer, atherosclerosis and arthritis are characterized by upregulation of activated matrix metalloproteinases (MMPs). For this reason imaging and quantification of activated MMPs with the mol. imaging techniques such as single photon emission computed tomog. (SPECT) and positron emission tomog. (PET) using radiolabeled MMP inhibitors would be a valuable tool for the diagnosis and therapy planning of mentioned diseases. This work aims at the synthesis and preliminary in vitro and in vivo evaluation of positron-emitter 18F-fluorine labeled radiotracers based on 2-{[(4-phenoxyphenyl)sulfonyl]methyl}thiirane (SB-3CT), a slow-binding and mechanism-based MMP-2 and -9 inhibitor. Therefore, a library of fluorinated SB-3CT derivatives were prepared and evaluated in vitro in MMP inhibition assays. From this pool the 18F-labeled triazole [18F]18d was successfully synthesized in a two-step procedure. However, this compound was unstable in human and mouse serum and showed a biodistribution behavior in C57BL/6 mice that is not favorable for PET imaging preventing further in vivo evaluations in MMP-associated mouse models of disease.
ChemistrySelect published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia