Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, SDS of cas: 17351-62-1.
Li, Zibo published the artcileAutomated synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-¦Â-D-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module, SDS of cas: 17351-62-1, the publication is Nuclear Medicine and Biology (2011), 38(2), 201-206, database is CAplus and MEDLINE.
2′-Deoxy-2′-[18F]fluoro-5-methyl-1-¦Â-D-arabinofuranosyluracil ([18F]-FMAU) is an established PET probe used to monitor cellular proliferation. For clin. applications, a fully automated cGMP-compliant radiosynthesis would be preferred. However, the current synthesis of [18F]-FMAU requires a multistep procedure, making the development of an automated protocol difficult and complicated. Recently, we have developed a significantly simplified one-pot reaction condition for the synthesis of [18F]-FMAU in the presence of Friedel-Crafts catalysts. Here, we report a fully automated synthesis of [18F]-FMAU based on a one reactor radiosynthesis module using our newly developed synthetic method. The product was purified on a semi-preparative high-performance liquid chromatog. integrated with the synthesis module using 6% EtOH in 10 mM phosphate buffer or 8% MeCN/water. [18F]-FMAU was obtained in 12¡À3% radiochem. yield (decay corrected overall yield based on [18F]-F–, n=4) with 383¡À33 mCi/¦Ìmol specific activity at the time of injection. The ¦Á/¦Â anomer ratio was 4:6. The overall reaction time was about 150 min from the end of bombardment and the radiochem. purity was >99%. This automated synthesis should also be suitable for the production of other 5-substituted thymidine analogs.
Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, SDS of cas: 17351-62-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia